Comparison of piperacillin plasma concentrations in a prospective randomised trial of extended infusion versus intermittent bolus of piperacillin/tazobactam in paediatric patients

Chongcharoenyanon, Tatchanapong; Wacharachaisurapol, Noppadol; Anugulruengkitt, Suvaporn; Maimongkol, Passara; Anunsittichai, Orawan; Sophonphan, Jiratchaya; Chatsuwan, Tanittha; Puthanakit, Thanyawee

doi:10.1016/j.ijid.2021.05.044

Cited by 12 publications

(10 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chongcharoenyanon et al designed a randomized controlled trial to compare piperacillin target attainment between extended infusion and intermittent bolus methods in children. Those who received extended infusion had a higher proportion of patients who achieved 50% f T>MIC [90.9% vs. 60.0% (P = 0.11)] and 50% f T>4x MIC [72.7% vs. 30.0% (P = 0.06)], but the authors could not demonstrate significant differences in clinical outcomes between groups (20). The other four studies used a population pharmacokinetics approach to evaluate PTA of different simulated dosing regimens (16)(17)(18)(19).…”

Section: Penicillinsmentioning

confidence: 89%

“…Most authors of the included articles recommended extending the infusion time (which includes prolonged and continuous infusions) and increasing dosing frequency to increase the PTA of beta-lactams ( 12 , 16 , 17 , 19 , 24 , 29 , 44 ). Chongcharoenyanon et al demonstrated in a prospective, randomized trial that septic children receiving extended infusion of piperacillin present significantly higher target attainment and they recommended this approach should be implemented in clinical practice ( 20 ).…”

Section: Discussionmentioning

confidence: 99%

“…Five studies reported PK/PD data of piperacillin (16)(17)(18)(19)(20). Chongcharoenyanon et al designed a randomized controlled trial to compare piperacillin target attainment between extended infusion and intermittent bolus methods in children.…”

Section: Penicillinsmentioning

confidence: 99%

See 2 more Smart Citations

Beta-Lactams Therapeutic Monitoring in Septic Children–What Target Are We Aiming for? A Scoping Review

et al. 2022

View full text Add to dashboard Cite

The antimicrobial therapy of sepsis and septic shock should be individualized based on pharmacokinetic/pharmacodynamic (PK/PD) parameters to deliver effective and timely treatment of life-threatening infections. We conducted a literature scoping review to identify therapeutic targets of beta-lactam antibiotics in septic pediatric patients and the strategies that have been applied to overcome sepsis-related altered pharmacokinetics and increase target attainment against susceptible pathogens. A systematic search was conducted in the MEDLINE, EMBASE and Web of Science databases to select studies conducted since 2010 with therapeutic monitoring data of beta-lactams in septic children. Last searches were performed on 02 September 2021. Two independent authors selected the studies and extracted the data. A narrative and qualitative approach was used to summarize the findings. Out of the 118 identified articles, 21 met the eligibility criteria. Population pharmacokinetic modeling was performed in 12 studies, while nine studies reported data from bedside monitoring of beta-lactams. Most studies were conducted in the United States of America (n = 9) and France (n = 5) and reported PK/PD data of amoxicillin, ampicillin, azlocillin, aztreonam, cefazolin, cefepime, cefotaxime, ceftaroline, ceftazidime, doripenem, meropenem and piperacillin/tazobactam. Therapeutic targets ranged from to 40% fT> MIC to 100% fT> 6 × MIC. Prolonging the infusion time and frequency were most described strategies to increase target attainment. Monitoring beta-lactam serum concentrations in clinical practice may potentially maximize therapeutic target attainment. Further studies are required to define the therapeutic target associated with the best clinical outcomes.

show abstract

Section: Penicillinsmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Beta-Lactams Therapeutic Monitoring in Septic Children–What Target Are We Aiming for? A Scoping Review

et al. 2022

View full text Add to dashboard Cite

show abstract

“…32 There are also other publications that cited the WBDP's description of the minimum clinical criteria for BD/DNC determination as the reference standard and reinforced the message that BD/DNC is first and foremost a clinical assessment, and while nearly all of them refer to human patients, there is one case report on resuscitation of a dog after OHCA that mentioned the WBDP prescribes the need for observation prior to consideration of BD/DNC evaluation after HIBI. 99 100 101 102 103 104 105 106 107 108…”

Section: Review Of the Wbdp And Updates Since Publicationmentioning

confidence: 99%

An Update on Brain Death/Death by Neurologic Criteria since the World Brain Death Project

Lewis

2024

Semin Neurol

View full text Add to dashboard Cite

The World Brain Death Project (WBDP) is a 2020 international consensus statement that provides historical background and recommendations on brain death/death by neurologic criteria (BD/DNC) determination. It addresses 13 topics including: (1) worldwide variance in BD/DNC, (2) the science of BD/DNC, (3) the concept of BD/DNC, (4) minimum clinical criteria for BD/DNC determination, (5) beyond minimum clinical BD/DNC determination, (6) pediatric and neonatal BD/DNC determination, (7) BD/DNC determination in patients on ECMO, (8) BD/DNC determination after treatment with targeted temperature management, (9) BD/DNC documentation, (10) qualification for and education on BD/DNC determination, (11) somatic support after BD/DNC for organ donation and other special circumstances, (12) religion and BD/DNC: managing requests to forego a BD/DNC evaluation or continue somatic support after BD/DNC, and (13) BD/DNC and the law. This review summarizes the WBDP content on each of these topics and highlights relevant work published from 2020 to 2023, including both the 192 citing publications and other publications on BD/DNC. Finally, it reviews questions for future research related to BD/DNC and emphasizes the need for national efforts to ensure the minimum standards for BD/DNC determination described in the WBDP are included in national BD/DNC guidelines and due consideration is given to the recommendations about social and legal aspects of BD/DNC determination.

show abstract

“…In more severe infections, 100% fT > MIC may be required. A recently published randomized controlled trial (RCT) comparing intermittent bolus (IB) with extended infusion (EI) of piperacillin found that the EI group had better antibiotic exposure ( Chongcharoenyanon et al, 2021 ). Population PKs with dose simulation studies of meropenem in both adults and children demonstrated a greater probability of target attainment (PTA) by EI administration compared with IB administration, especially for bacteria with increased MICs ( Cies et al, 2017 ;Jaruratanasirikul et al, 2011 ;Kongthavonsakul et al, 2016 ;Ohata et al, 2011 ;Ulldemolins et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Therapeutic drug monitoring of meropenem and pharmacokinetic-pharmacodynamic target assessment in critically ill pediatric patients from a prospective observational study

Maimongkol

Yonwises

Anugulruengkitt

et al. 2022

International Journal of Infectious Diseases

Self Cite

View full text Add to dashboard Cite

Comparison of piperacillin plasma concentrations in a prospective randomised trial of extended infusion versus intermittent bolus of piperacillin/tazobactam in paediatric patients

Cited by 12 publications

References 29 publications

Beta-Lactams Therapeutic Monitoring in Septic Children–What Target Are We Aiming for? A Scoping Review

Beta-Lactams Therapeutic Monitoring in Septic Children–What Target Are We Aiming for? A Scoping Review

An Update on Brain Death/Death by Neurologic Criteria since the World Brain Death Project

Therapeutic drug monitoring of meropenem and pharmacokinetic-pharmacodynamic target assessment in critically ill pediatric patients from a prospective observational study

Contact Info

Product

Resources

About