Comparison of physical, mechanical and biological effects of leucocyte-PRF and advanced-PRF on polyacrylamide nanofiber wound dressings: In vitro and in vivo evaluations

Keratin- and VEGF-Incorporated Honey-Based Sponge–Nanofiber Dressing: An Ideal Construct for Wound Healing

“…Also, in Figure c, it can be seen that the thickness of CAM has increased in the samples treated with dressing materials, especially in the PAAc–Hny/Hny–Kr–VEGF sample, compared to the control, which indicates the increase in cell activity and collagen deposition. Also, the number of organized cells and neoangiogenesis areas are more in these samples (especially in the PAAc–Hny/Hny–Kr–VEGF). , The beneficial impact of Kr on the angiogenesis process has already been demonstrated in a study by Gao et al Additionally, the presence of VEGF could significantly improve the angiogenesis in comparison to that in other samples, which confirmed that the endothelial mitogenic response is predominantly brought on by VEGF, a powerful angiogenic growth factor …”

“…Angiogenesis, a process of formation of new blood vessels from the existing capillaries, is crucial for inflammatory processes and repair in injured body tissues. Regeneration of blood vessels to establish 58,59 The beneficial impact of Kr on the angiogenesis process has already been demonstrated in a study by Gao et al 60 Additionally, the presence of VEGF could significantly improve the angiogenesis in comparison to that in other samples, which confirmed that the endothelial mitogenic response is predominantly brought on by VEGF, a powerful angiogenic growth factor. This can be attributed to the anti-inflammatory effect of Hny.…”

Natural polymers in wound healing: From academic studies to commercial products

“…The skin is the largest human organ, covered entire human body to prevent the invasion of microorganisms, which it does by creating a physical barrier against the external environment. Other skin defense mechanisms include immunological, metabolical, UV protection, body temperature regulation, and prevention of dehydration 1–4 . The importance of wound treatment has increased due to the prevalence of chronic high‐risk wounds, especially in the elderly, immunocompromised patients, and diabetics.…”

“…Other skin defense mechanisms include immunological, metabolical, UV protection, body temperature regulation, and prevention of dehydration. [1][2][3][4] The importance of wound treatment has increased due to the prevalence of chronic high-risk wounds, especially in the elderly, immunocompromised patients, and diabetics. Wound healing is a complex process consisting of four successive physiological stages including coagulation, inflammation, cell proliferation, and tissue regeneration.…”