Comparison of Photodynamic Therapy versus conventional antifungal therapy for the treatment of denture stomatitis: a randomized clinical trial

Abstract

In this randomized clinical trial, the clinical and mycological efficacy of Photodynamic Therapy (PDT) was compared with that of topical antifungal therapy for the treatment of denture stomatitis (DS) and the prevalence of Candida species was identified. Patients were randomly assigned to one of two groups (n = 20 each); in the nystatin (NYT) group patients received topical treatment with nystatin (100,000 IU) four times daily for 15 days and in the PDT group the denture and palate of patients were sprayed with 500 mg/L of Photogem(®), and after 30 min of incubation, were illuminated by light emitting-diode light at 455 nm (37.5 and 122 J/cm(2), respectively) three times a week for 15 days. Mycological cultures taken from dentures and palates and standard photographs of the palates were taken at baseline (day 0), at the end of the treatment (day 15) and at the follow-up time intervals (days 30, 60 and 90). Colonies were quantified (CFU/mL) and identified by biochemical tests. Data were analysed by Fisher's exact test, analysis of variance and Tukey tests and κ test (α = 0.05). Both treatments significantly reduced the CFU/mL at the end of the treatments and on day 30 of the follow-up period (p <0.05). The NYT and PDT groups showed clinical success rates of 53% and 45%, respectively. Candida albicans was the most prevalent species identified. PDT was as effective as topical nystatin in the treatment of DS.

Fungicidal effect of combined nano TiO2 with erythrosine for mediated photodynamic therapy on Candida albicans: an in vitro study

“…To date, the direct comparison has never been reported yet. Mima et al (2012) [22] compared the antifungal efficacy of 500 mg/L Photogem with topical nystatin cream in Candida-induced denture stomatitis in a randomized controlled trial setting. They found that both treatments significantly reduced the fungal burden at the end of the treatment.…”

Mycoplasma Removal from Cell Culture Using Antimicrobial Photodynamic Therapy

“…7,[22][23][24] It is important to establish protocols that enhance the selectivity of the photodynamic process toward microbial targets for the clinical application of aPDT, with minimal collateral damage to the hosts. 25,26 It is also important to establish protocols for the complete removal of bacteria without damaging cells when removing bacteria from cell lines using aPDT.…”

Photodynamic Therapy As a Promising Method Used in the Treatment of Oral Diseases

“…The same author also conducted a clinical trial to compare the effects of photodisinfection with a topical application of nystatin, which is conventionally used in the treatment of denture stomatitis [77]. PDT appeared to be as effective as the topical antibiotic in reducing the number of pathogens from dentures and palates.…”