Comparison of peritonsillar levobupivacaine and bupivacaine infiltration for post-tonsillectomy pain relief in children: Placebo-controlled clinical study

Kasapoğlu, Fikret; Kaya, Fatma Nur; Tüzemen, Gökhan; Ozmen, Omer Afşın; Kaya, Atila; Onart, Selçuk

doi:10.1016/j.ijporl.2010.11.015

Cited by 23 publications

(14 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to intravenous, intramuscular, and oral or rectal postoperative analgesic use, various methods have been tried, such as the injection of anaesthetic substances or penicillin-steroid mixtures into the tonsillar fossa postoperatively if pain develops postoperatively [ 10 , 14 ]. Although some studies show that LA infiltration decreases postoperative sore throat [ 3 , 4 , 10 , 16 ], other studies show that it is not useful for decreasing postoperative pain [ 2 , 4 , 14 , 17 ]. The reasons for these differences are said to be the steroid and additional sedative drugs used in premedication, the technique of tonsillectomy, the technique of peritonsillar injection, volume and dose of LA, and postoperative pain evaluation methods.…”

Section: Discussionmentioning

confidence: 99%

“…In a study that presented the dependence of time to first analgesic request on perioperative LA infiltration, Basuni et al measured the time to first analgesic request to be 373.2 ± 63.6 minutes when they used levobupivacaine [ 27 ]. Kasapoglu et al found a significant difference between their levobupivacaine group and their control group in terms of the time to first analgesic request [ 3 ]. In our study, similar to the findings of Basuni et al, the times to first analgesic request in groups L and LA were 379.1 ± 172.3 and 383.8 ± 173.5 minutes, respectively [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

“…Tonsillectomy is among the most frequently performed surgical procedures for commonly seen occlusive and recurrent infections in otolaryngology [ 1 ]. Patients frequently complain of pain on swallowing after this operation [ 2 , 3 ]. Furthermore, postoperative sore throat may cause adverse effects that decrease oral intake and lead to dehydration [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Comparison of the Perioperative and Postoperative Effects of Levobupivacaine and of Levobupivacaine + Adrenaline in Pediatric Tonsillectomy: A Double-Blind Randomized Study

Çiçekci

Sizer

Atici

et al. 2017

Pain Research and Management

View full text Add to dashboard Cite

Objectives We aimed to assess the effects of levobupivacaine and of levobupivacaine + adrenaline administered during pediatric tonsillectomy on the postoperative period. Methods A total of 90 patients between the ages of five and twelve were divided randomly into two groups before tonsillectomy: levobupivacaine only (0.5%) 0.4 mg·kg−1 or levobupivacaine (0.5%) 0.4 mg·kg−1 + adrenaline (1 : 200.000) administered by means of peritonsillar infiltration. Primary outcomes were postoperative pain scores recorded at various intervals until 24 hours postoperatively. Secondary outcomes included postoperative nausea and vomiting (PONV), time to first oral intake, time to the first administration of analgesics and total consumption of analgesics, and the amount of bleeding for all children. Results In both groups, patients had the same postoperative pain scores and PONV rates, and equal amounts of analgesics were consumed up to 24 hours postoperatively. The two groups also had the same time until first oral intake, recovery time and time to the first analgesic request, and amount of bleeding. Conclusions Perioperative levobupivacaine infiltration on its own is a valid alternative to the combination of levobupivacaine + adrenaline for perioperative and postoperative effectiveness in pediatric tonsillectomy. This trial is registered with Australian New Zealand Clinical Trial Registry ACTRN: ACTRN12617001167358.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of the Perioperative and Postoperative Effects of Levobupivacaine and of Levobupivacaine + Adrenaline in Pediatric Tonsillectomy: A Double-Blind Randomized Study

Çiçekci

Sizer

Atici

et al. 2017

Pain Research and Management

View full text Add to dashboard Cite

show abstract

“…[28–30] The rate of titration of the opioids dose, rather than target dose, is the major determinant of a patient's tolerability. [3132] In our study, patient satisfaction was significantly higher in groups P and T when compared with groups B and C [Table 4]. However, it should be remembered that the analgesic efficacy is likely dependent upon multiple variables.…”

Section: Discussionmentioning

confidence: 76%

The comparison of intraincisional injection tramadol, pethidine and bupivacaine on postcesarean section pain relief under spinal anesthesia

et al. 2012

View full text Add to dashboard Cite

Background:Bupivacaine, tramadol, and pethidine has local anesthetic effect. The aim of this study was to compare effect of subcutaneous (SC) infiltration of tramadol, pethidine, and bupivacaine on postoperative pain relief after cesarean delivery.Materials and Methods:120 patient, scheduled for elective cesarean section under spinal anesthesia, were randomly allocated to 1 of the 4 groups according to the drugs used for postoperative analgesia: Group P (Pethidine) 50 mg ,Group T (Tramadol) 40 mg, Group B (Bupivacaine 0.25%) 0.7 mg/kg, and Group C (control) 20CC normal saline injection in incision site of surgery. Pain intensity (VAS = visual analogous scale) at rest and on coughing and opioid consumption were assessed on arrival in the recovery room, and then 15, 30, 60 minutes and 2, 6, 12, 24 hours after that.Results:VAS scores were significantly lower in groups T and P compared with groups B and C except for 24 hours (VAS rest) and 6 hours (VAS on coughing) postoperatively (P < 0.05). The number of patients requiring morphine were significantly different between the groups (105 doses vs. 87, 56, 46, doses for group C, B, T and P, respectively, P < 0.05) in all the times, except for 2 and 6 hours postoperatively.Conclusions:The administration of subcutaneous pethidine or tramadol after cesarean section improves analgesia and has a significant morphine-sparing effect compared with bupivacaine and control groups.

show abstract

“…As the preventive method of reducing postoperative pains by blocking the pain impulses and preventing from their entrance into the central nerve systems, bupivacaine infiltration produces analgesia(12). Some studies in some countries have reported the significant effect of this drug on relieving post-tonsillectomy pain (13)(14)(15)(16). Some others though do not consider it as an effective way to prevent from pain (17)(18)(19)(20).…”

Section: Introductionmentioning

confidence: 99%

The role of local injection of Bupivacaine in the management of pain after tonsillectomy surgery

Javaherforooshzadeh¹,

Derakhshandeh

Atigh³

2016

IJB

View full text Add to dashboard Cite

Pain relief after tonsillectomy is an important part of post-operative management. There are some common drugs and local anesthetics such as bupivacaine used to treat postoperative pain. This research was aimed to assess the role of local injection of bupivacaine in the management of pain after tonsilectomy surgery 96patients aged 5–12 were included in a double-blind clinical trial prospective study. Patients in treatment group received an injection 3cc of 0.5% bupivacaine solution in side and upper peritonsillar areas, and patients in group B were injected 3cc of normal saline in the same area. Patients were asked to Visual Analog Score, After tracheal extubation, 1st, 2th, 4th, 8th,12th, and 24th hours after operation. The first request for analgesic and the total amount of analgesic consumption was also recorded. Regarding to Visual Analog Score over a 24-h period, there was a significant difference between two groups (p<0.05). Also demand for analgesic in 24 hours after surgery was significantly less in treatment group than in placebo (p<0.001). preoperative local 0.5% bupivacaine injection in tonsillectomy patients was effective relieves the post-tonsillectomy pain and significantly reduces opioid consumption in kids.

show abstract

Comparison of peritonsillar levobupivacaine and bupivacaine infiltration for post-tonsillectomy pain relief in children: Placebo-controlled clinical study

Cited by 23 publications

References 37 publications

Comparison of the Perioperative and Postoperative Effects of Levobupivacaine and of Levobupivacaine + Adrenaline in Pediatric Tonsillectomy: A Double-Blind Randomized Study

Comparison of the Perioperative and Postoperative Effects of Levobupivacaine and of Levobupivacaine + Adrenaline in Pediatric Tonsillectomy: A Double-Blind Randomized Study

The comparison of intraincisional injection tramadol, pethidine and bupivacaine on postcesarean section pain relief under spinal anesthesia

The role of local injection of Bupivacaine in the management of pain after tonsillectomy surgery

Contact Info

Product

Resources

About