Comparison of peripheral endothelial dysfunction and intimal media thickness in patients with suspected coronary artery disease

Enderle, Markus D.; Schroeder, Stephen; Ossen, Runald; Meisner, Christoph; Baumbach, Andreas; Haering, Hans U.; Karsch, Karl R.; Pfohl, Martin

doi:10.1136/hrt.80.4.349

Cited by 85 publications

(75 citation statements)

References 30 publications

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“…In contrast with Enderle and cols. 17 , there was no correlation between the arterial intimal-medial thickening and the degree of coronary obstruction, but the same observations regarding the defi nition of disease severity discussed above must be considered.…”

Section: Chequer Et Al Carotid Intimal-medial Thickening and Endothelmentioning

confidence: 88%

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Espessamento médio-intimal da carótida e função endotelial na doença arterial coronariana

Chequer¹,

Nascimento²,

Navarro³

et al. 2006

Arq. Bras. Cardiol.

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M a i l i n g A d d r e s s :G r a z i e l a C h e q u e r • R u a M o n t e s C l a r o s , 4 7 5 / 7 0 2 -3 0 3 1 0 -3 7 0 -B e l o H o r i z o n t e , M G -B r a z i l E-mail: grazichequerr@hotmail. OBJECTIVETo investigate the correlation between the endothelial function and the carotid intimal-medial thickening (IMT) in a population of patients with coronary artery disease, as well as that between the endothelial function and carotid IMT with the severity of the coronary lesions. METHODSForty-three patients aged 60.5±9.2 years, (67.4% males) with coronary artery disease at the coronariography were studied. Endothelial function was assessed using the brachial artery reactivity test (BART), which measured the percentage of fl ow-mediated dilatation (%FMD). The carotid IMT was evaluated through vascular ultrasound. RESULTSThe mean %FDM was 4.7 ± 3.6 and the mean carotid IMT was 1.08 ± 0.23 mm. The carotid MIT and %FMD measurements showed a statistically signifi cant correlation, with Spearman's coefficient of 0.315, p= 0.042, demonstrating that lower %FMD values corresponded to an increased carotid IMT (r = -0.315, p = 0.042). There was no correlation between %FMD or IMT and the severity of coronary lesions. CONCLUSIONThe presence of a correlation between carotid IMT and %FMD demonstrates a concomitance of anatomical and functional vascular alterations in coronary artery disease, regardless of the severity of the atherosclerotic lesions.

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Section: Chequer Et Al Carotid Intimal-medial Thickening and Endothelmentioning

confidence: 88%

“…These data are in accordance with those demonstrated by Enderle and cols. 17 in a group of patients highly suspected of having coronary disease (r=-0.317, p= 0.0004). Campuzano and cols.…”

Section: Chequer Et Al Carotid Intimal-medial Thickening and Endothelmentioning

confidence: 99%

Espessamento médio-intimal da carótida e função endotelial na doença arterial coronariana

Chequer¹,

Nascimento²,

Navarro³

et al. 2006

Arq. Bras. Cardiol.

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“…Carotid intima-media thickness (CIMT), flow associated dilatation (FAD %) and nitric oxide sensitivity of the smooth muscle cell of the brachial artery to nitroglycerine (GTN %) are legitimate markers of early atherosclerosis (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24). CIMT is a surrogate marker for generalized atherosclerosis and imparts prognostic information independent of traditional cardiovascular risk factors.…”

Section: Introductionmentioning

confidence: 99%

“…FAD % is a sensitive predictor of CAD, although it is unable to predict both the extent and the severity of angiographically assessed CAD (12)(13)(14). GTN % is an index of endothelium independent vasodilatation and a reduced GTN % is a valuable marker in predicting more advanced coronary atherosclerosis (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the effects of chronic biomass fuel smoke exposure on peripheral endothelial functions: an observational study

Buturak¹,

Genç²,

Ulus³

et al. 2011

Anadolu Kardiyol Derg

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ÖZETAmaç: Hayvansal biyokütle yakıtı (tezek) dumanı inhalasyon ürünlerine kronik olarak maruz kalan bireylerde endoteliyal fonksiyonların değer-lendirilmesi. Yöntemler: Doğumlarından itibaren tezek dumanı inhalasyon ürünleri maruziyeti olan 47 sağlıklı birey (ortalama yaş 31.6±6.8 yıl, 21 erkek) enine kesitli gözlemsel çalışmaya dahil edildi. Kontrol grubu ise 32 sağlıklı kişiden (ortalama yaş 27.9±4.4 yıl, 11 erkek) oluşturuldu. Tüm bireylerde, karotis intima media kalınlığı (CIMT), akım ile ilişkili dilatasyon (FAD %) ve endotel-bağımlı olmayan vazodilatasyon (GTN %) değerlendirildi. CIMT, lümen-intima ile media-adventisya yüzeylerinin önde gelen kenarları arasındaki mesafe olarak hesaplandı. FAD %, reaktif hiperemi sıra-sında brakiyal arter lümen çapının başlangıç düzeyine göre yüzde değişimi olarak tanımlanırken, GTN % ise, 400 µg gliseriltrinitrat uygulandıktan dört dakika sonra ölçülen brakiyal arter lümen çapının başlangıç düzeyine göre yüzde değişimi olarak tanımlanmıştır. İstatistiksel analiz Student t-testi, Ki-kare testi ve Spearman korelasyon katsayısı analizi ile yapıldı. Bulgular: Her iki grubun CIMT değerleri arasında istatistiksel açıdan anlamlı farklılık yoktur (0.47±0.09'a karşın 0.49±0.06 mm, p=0.138). Ancak, kontrol grubu ile karşılaştırıldığında, çalışma grubundaki kişilerin FAD % değerleri belirgin azalmış olarak saptanmıştır (5.06±4.95'e karşın 10.70±4.64, p<0.001). Buna ilaveten, tezek maruziyeti olan kimselerin GTN % değerleri de kontrol grubuna göre düşük düzeylerde bulunmuştur (14.41±8.47'ye karşın21.85±7.87, p<0.001). ABSTRACTObjective: To evaluate the effect of chronic biomass fuel (BMF) smoke exposure on peripheral endothelial functions. Methods: Forty-seven healthy subjects who have been exposed to BMF smoke since birth (mean age 31.6±6.8 years, 21 male) were enrolled in the present cross-sectional observational study. The control group consisted of 32 healthy subjects (mean age 27.9±4.4 years, 11 male). The carotid intima media thickness (CIMT), flow associated dilatation (FAD %) and endothelium independent vasodilatation (GTN %) were assessed in all subjects. The carotid CIMT was defined as the distance between the leading edge of the lumen-intima and the media-adventitia interfaces. FAD % was defined as the percentage change in the internal diameter of the brachial artery during reactive hyperemia related to the baseline. GTN % was defined as the change in diameter in response to the application of 400 µg of glyceril trinitrate relative to the baseline scan at the end of the fourth minute. Statistical analysis was performed using Student's t-test, Chi-square test and Spearman rank order correlation analysis. Results: The average exposure time of the subjects to biomass fuel smoke was 31.7±6.6 years. They have been exposed to dung inhalation products meanly 8.3±1.8 months in a year seasonally. The average daily exposure time was 15.7±3.3 hours. CIMT values of the two groups were not statistically different from each other (0.47±0.09 vs. 0.49±0.06 mm, p=0.138). However, a markedly...

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“…While QCA and CIMT are associated with prevalent CVD and have strong prognostic value for incident CVD independent of risk profiles [1,3,[6][7][8][9], the diagnostic and prognostic importance of BFMD for CVD is less certain [10]. Although some studies have shown BFMD to be predictive of future coronary events [11,12], only a handful of studies have reported an inverse association between BFMD and CIMT [13][14][15][16][17][18]. The majority of these studies were small, cross-sectional evaluations of men with pre-existing coronary artery disease (CAD) [13,[15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Brachial artery vasoreactivity is associated with cross-sectional and longitudinal anatomical measures of atherosclerosis in postmenopausal women with coronary artery disease

et al. 2008

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Background-The diagnostic and prognostic importance of brachial artery flow-mediated dilation (BFMD) for cardiovascular disease (CVD) is not certain and associations between BFMD and recognized measures of atherosclerosis have not been well established.Methods-We investigated cross-sectional and longitudinal correlations between repeated measures of BFMD and quantitative coronary artery angiographic (QCA) measurements of average percent diameter stenosis, number of lesions and minimum luminal diameter (MLD), and ultrasonographic measurement of carotid artery intima-media thickness (CIMT) in an ethnically diverse cohort of postmenopausal women (n = 132) with coronary artery disease (CAD). Subjects were participants in a 3-year randomized, placebo-controlled clinical trial, testing the efficacy of hormone therapy on atherosclerosis progression. Associations between BFMD and QCA measures, and between BFMD and CIMT were examined using measurements from the same study visit. Conclusions-Physiological and anatomical measures of atherosclerosis are correlated among postmenopausal women with CAD, which provides some validation of BFMD as a measure of atherosclerosis in high-risk populations. Results-BFMD

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Comparison of peripheral endothelial dysfunction and intimal media thickness in patients with suspected coronary artery disease

Abstract: Conclusions-In patients with clinically suspected coronary artery disease, FAD% discriminates between the presence or absence of coronary artery disease, whereas intimal media thickness is associated more with the extent of coronary artery disease. (Heart 1998;80:349-354)

Cited by 85 publications

References 30 publications

Espessamento médio-intimal da carótida e função endotelial na doença arterial coronariana

Espessamento médio-intimal da carótida e função endotelial na doença arterial coronariana

Evaluation of the effects of chronic biomass fuel smoke exposure on peripheral endothelial functions: an observational study

Brachial artery vasoreactivity is associated with cross-sectional and longitudinal anatomical measures of atherosclerosis in postmenopausal women with coronary artery disease

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