Comparison of perioperative outcomes and anesthetic-related complications of morbidly obese and super-obese parturients delivering by cesarean section

Abstract

Objective To compare the perioperative outcomes and anesthetic-related complications of morbidly obese and super-obese parturients delivering by cesarean section. Methods A retrospective analysis of 6 years of data was performed. Exclusions were cases with gestational ages <24 weeks, placenta accreta spectrum, polyhydramnios, or multiple gestations. Results The study included 494 patients whose body mass index (BMI) exceeded 40 kg/m 2 at delivery. Of these, 469 were morbidly obese (BMI 40–49.9; mean, 42.9 ± 2.4), and 25 were super obese (BMI >50; mean, 54.5 ± 4.2). Twenty-four (5.1%) morbidly obese women received general anesthesia. The other 445 patients (94.9%) in the morbid obesity group underwent cesarean delivery under regional anesthesia; however, some (2.2%; 10/445) received general anesthesia after regional anesthesia failed. In the super-obesity group, 23 patients (92.0%) received regional anesthesia, while two patients (8.0%) received general anesthesia. There were no cases of pulmonary aspiration, maternal deaths, or difficult or failed intubation. There was one episode of cardiac arrest in a patient with a BMI of 47.9. Among the morbidly obese and super-obese women given regional anesthesia, the super-obese patients had significantly greater volumes of ephedrine and norepinephrine consumption ( p = 0.027 and 0.030), intravenous fluids ( p = 0.006), and bleeding during surgery ( p = 0.017). They also had more hypotensive episodes ( p = 0.038). The two groups’ incidences of neonatal birth asphyxia, postpartum hemorrhage, blood transfusion, and uterine atony did not differ significantly. The lengths of stay in the hospital were also comparable. Conclusions Among the women receiving regional anesthesia, the super-obese parturients had greater intraoperative bleeding, a higher proportion of hypotensive episodes, and a greater vasopressor requirement than the morbidly obese parturients. Anesthesiologists must prepare for the adverse perioperative events that such women risk experiencing during a delivery by cesarean section. Trial registration www.clinicaltrials.gov ID: NCT04657692.

Case report: Maternal cardiac arrest at 12 hours postpartum

“…Thromboembolism also can be a cause of cardiac arrest in the peripartum period and is a significant concern for obese parturients [ 10 ]. Reports have demonstrated cases of cardiac arrest resulting from pulmonary embolism in morbidly obese parturients during the perioperative period [ 11 , 12 ]. Given the absence of thromboprophylaxis in our patient, thromboembolism should be considered as a potential differential diagnosis.…”

Prospective Study on the Correlation between CART and Leptin Gene Expression, Obesity, and Reproductive Hormones in Individuals Undergoing Bariatric Surgery

“…Our study included women with a BMI > 40 kg/m 2 [27]. Although we collected blood samples before and after the bariatric surgery, we could not repeat the experiment one year later to investigate the gene expression further.…”

Obese Parturient: A Modern-Day Obstetric Challenge

“…Previous and recent studies found that in morbidly obese patients undergoing cesarean delivery, the incidence of intra-operative and post-operative complications including gestational diabetes, preeclampsia, hypotensive episodes, post-partum hemorrhage (PPH), preterm birth, stillbirth, neonatal seizures, and macrosomia were significantly higher than in non-obese patients [5][6][7][8]. Hence, morbidly obese patients require special consideration during labor, delivery, and post-partum care.…”