Comparison of Performance and Cost-Effectiveness of Direct Fluorescent-Antibody, Ligase Chain Reaction, and PCR Assays for Verification of Chlamydial Enzyme Immunoassay Results for Populations with a Low to Moderate Prevalence of
            <i>Chlamydia trachomatis</i>
            Infection

Dean, Deborah; Ferrero, D; McCarthy, Michael

doi:10.1128/jcm.36.1.94-99.1998

Cited by 43 publications

(10 citation statements)

References 31 publications

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“…However, this lower prevalence in the latter study may reflect the fact that only urine was used for screening. Previous research has shown that urine testing will miss up to 30% of endocervical C. trachomatis infections [19,29]. Interestingly, in the only published study from the PICT of non-pregnant females, urine testing showed a prevalence of 36% among women 18 to 29 years of age in Samoa [30], suggesting that genital prevalence may be even higher.…”

Section: Discussionmentioning

confidence: 98%

Hyperendemic Chlamydia trachomatis sexually transmitted infections among females represent a high burden of asymptomatic disease and health disparity among Pacific Islanders in Fiji

et al. 2020

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Background Chlamydia trachomatis is the most common bacterial sexually transmitted infection worldwide with some of the highest prevalence rates among Pacific Island Countries where syndromic management is practiced. However, little is known about the true prevalence and risk indicators for infection among neglected populations in these countries that suffer from health disparities. Methodology/Principal findings Consecutive sampling was used to enroll sexually active females, aged 18-40 years, attending 12 Fijian Ministry of Health and Medical Services Health Centers and outreach locations from February to December, 2018. A Behavioral Surveillance Survey was administered to assess risk indicators for infection. Signs and symptoms were recorded, and vaginal swabs were tested for C. trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, Candida and bacterial vaginosis. Bivariate and multivariate logistic regression analyses were performed using R-Studio. Of 577 participants, 103 (17.85%) were infected with C. trachomatis of whom 80% were asymptomatic and only 11 met criteria for syndromic management; 38.8% of infected women were 18-24 years old with a prevalence of 30.5%. 91.7% of participants intermittently or did not use condoms. C. trachomatis infection was associated with iTaukei ethnicity (OR 21.41 [95% CI: 6.38-133.53]); two lifetime partners (OR 2.12

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Section: Discussionmentioning

confidence: 98%

Hyperendemic Chlamydia trachomatis sexually transmitted infections among females represent a high burden of asymptomatic disease and health disparity among Pacific Islanders in Fiji

et al. 2020

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“…Although many studies have established optimal strategies for testing at-risk women, few studies have focused on women with a low prevalence of infection (18)(19)(20)(21). Howell et al (22) evaluated screening strategies for genital CT infection in Figure 3) Clinical reasons for physicians' assessment of women asymptomatic women attending two family practice clinics (6.6% overall prevalence of CT infection).…”

Section: Discussionmentioning

confidence: 99%

Reasons for Testing Women for Genital Chlamydia trachomatis Infection in the Calgary Region

Church

Zentner

Semeniuk

et al. 2003

Canadian Journal of Infectious Diseases and Medical Microbiolog

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“…Although many studies have established optimal strategies for testing at-risk women, few studies have focused on women with a low prevalence of infection (18)(19)(20)(21). Howell et al (22) evaluated screening strategies for genital CT infection in asymptomatic women attending two family practice clinics (6.6% overall prevalence of CT infection).…”

Section: Discussionmentioning

confidence: 99%

Reasons for testing women for genital Chlamydia trachomatis infection in the Calgary region

Church

Zentner²,

Semeniuk³

et al. 2003

J Sex Reprod Med

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OBJECTIVE: To determine the clinical reason(s) for screening women with varying degrees of risk for genital Chlamydia trachomatis (CT) in the Calgary region. DESIGN: Women aged 15 to 75 years were enrolled at various patient care locations. Pertinent risk factors for genital CT infection were recorded and a gynecological examination was performed. Two endocervical swabs and a first-void urine sample were collected for CT detection using two different nucleic acid amplification test methods. SETTING: Calgary is an urban region that provides healthcare services to a population of almost one million people. Microbiology services are provided by Calgary Laboratory Services through a centralized regional laboratory service. MAIN RESULTS: 504 women with a mean age of 28.1 ± SD 8.22 years were enrolled. Two hundred ninety-one women (57.8%) were at high risk for acquiring genital CT infection. Twenty-eight (5.6%) tested positive for CT infection and almost all of these women (26 of 28, 93%) had risk factors for acquiring infection. Of the high-risk women, 9.8% were CT positive versus only 1.3% of women at low risk (P=0.0001). Only two of 152 (1.3%) women older than 30 years had genital CT infections. Although most women were asymptomatic, those with laboratory-confirmed CT infection were more likely to have genitourinary symptoms. Three hundred forty-three of 476 (72%) women who did not have genital CT infection had no risk factors, and screening was done as part of a routine gynecological examination for other purposes (prenatal visit, Pap smear). CONCLUSION: Women without risk factors are being screened routinely for genital CT infection as part of a routine gynecological examination done for other reasons. Elimination of the routine screening of low-risk women older than 30 years of age would decrease the current regional utilization of CT tests by as much as one-third.

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Comparison of Performance and Cost-Effectiveness of Direct Fluorescent-Antibody, Ligase Chain Reaction, and PCR Assays for Verification of Chlamydial Enzyme Immunoassay Results for Populations with a Low to Moderate Prevalence of Chlamydia trachomatis Infection

Cited by 43 publications

References 31 publications

Hyperendemic Chlamydia trachomatis sexually transmitted infections among females represent a high burden of asymptomatic disease and health disparity among Pacific Islanders in Fiji

Hyperendemic Chlamydia trachomatis sexually transmitted infections among females represent a high burden of asymptomatic disease and health disparity among Pacific Islanders in Fiji

Reasons for Testing Women for Genital Chlamydia trachomatis Infection in the Calgary Region

Reasons for testing women for genital Chlamydia trachomatis infection in the Calgary region

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