Comparison of Pattern Electroretinography and Optical Coherence Tomography Parameters in Patients with Primary Open-Angle Glaucoma and Ocular Hypertension

Abstract

Objectives:To investigate the correlation of visual field (VF), pattern electroretinography (PERG) and Fourier domain optical coherence tomography (FD-OCT) results in patients with ocular hypertension (OHT) and early primary open-angle glaucoma (POAG).Materials and Methods:The study included 72 eyes of 37 patients with early POAG, 76 eyes of 38 patients with OHT, and 60 eyes of 30 controls. All subjects underwent full ophthalmologic examination, VF assessment with 24-2 Humphrey standard automated perimetry (Swedish Interactive Thresholding Algorithm (SITA)-Standard), retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thickness measurement with FD-OCT, and PERG P50 and N95 wave latency and amplitude measurements with electroretinography (Nihon Kohden).Results:With the exception of the nasal quadrant, all GCC parameters and RNFL results were significantly lower in the POAG group compared to the OHT and control groups. There was no statistically significant difference between the OHT and control group. PERG amplitudes were lower in the POAG and OHT groups than in the control group. Reduction in N95 amplitude was greater than that of P50 amplitude. No difference was detected in PERG latencies among groups. GCC was significantly correlated with VF and RNFL in the POAG group. Conclusion:Significant thinning of the GCC and RNFL occurs in addition to VF pathologies in patients with early POAG, and these examinations should be concomitantly evaluated. During diagnostic assessment of patients with early POAG, GCC and RNFL analysis by FD-OCT are highly effective. GCC is as reliable as RNLF in the early diagnosis of glaucoma and there is a highly significant correlation between them. Dysfunction of ganglion cells in patients with OHT may be detected earlier using PERG amplitude analysis.

Primary Open Angle Glaucoma Diagnosis Using Pattern Electroretinogram Parameters

“…They did not, however, include P50 or N95 latency in their study. Additionally, North et al 34 showed that, in comparison to the control group, the P50-N95 amplitude provided slightly better discrimination between 37 the N95 amplitude was lowered more than the P50 amplitude in the POAG and OHT groups compared to the control group. Also, they found that PERG amplitude analysis could detect ganglion cell dysfunction in OHT patients before OCT or visual field problems.…”

<p>Can We Corroborate Peripapillary RNFL Analysis with Macular GCIPL Analysis? Our 2-Year Experience at a Single-Centre Tertiary Healthcare Hospital Using Two OCT Machines and a Review of Literature</p>

“…Even Oli et al 22 in July 2015 and Fujimura et al 23 in Nov 2015 conducted similar studies on Cirrus HD OCT concluded that OCT could only be used as a supplementary tool to RNFL analysis. In Dec 2015, Demir et al 24 tried to elucidate a correlation between visual fields, pattern electroretinography (pERG) and FD-OCT parameters in patients with POAG and ocular hypertension (OHT). They concluded that the dysfunction due to GCC loss may be detected earlier using PERG analysis.…”

Electrophysiological markers of preclinical diagnosis of glaucomatous optic neuropathy

“…[32] в глазах с офтальмогипертензией получено значительное уменьшение по сравнению с контролем амплитуды N95 (p < 0,0002) и отношения амплитуд N95/P50 (p < 0,002), но пиковые латентности волн P50 и N95 были в пределах нормы. В других исследованиях также показано статистически значимое снижение по сравнению с контрольной группой амплитуды P50 и N95 при преимущественном угнетении N95 [33]. В исследованиях М.В.…”