2019
DOI: 10.1016/j.jaad.2019.04.015
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Comparison of patient-reported disease severity and sweat measurements in primary focal hyperhidrosis

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Cited by 5 publications
(7 citation statements)
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“…Furthermore, in a phase III study with SB 5%, the proportion of patients whose HDSS was improved to a score of 1 or 2 at the EOT and with a > 50% reduction in gravimetrically assessed sweat production at the EOT was 53·9% (SB) vs. 36·4% (placebo) 33 . Only minor positive trends between gravimetry and HDSS scores were found in primary focal HH 37 . The poor correlation may be due to the combination of distinct concepts of tolerability and interference with daily activities in a single, patient self‐reported rating question 36,38 .…”
Section: Discussionmentioning
confidence: 97%
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“…Furthermore, in a phase III study with SB 5%, the proportion of patients whose HDSS was improved to a score of 1 or 2 at the EOT and with a > 50% reduction in gravimetrically assessed sweat production at the EOT was 53·9% (SB) vs. 36·4% (placebo) 33 . Only minor positive trends between gravimetry and HDSS scores were found in primary focal HH 37 . The poor correlation may be due to the combination of distinct concepts of tolerability and interference with daily activities in a single, patient self‐reported rating question 36,38 .…”
Section: Discussionmentioning
confidence: 97%
“…33 Only minor positive trends between gravimetry and HDSS scores were found in primary focal HH. 37 The poor correlation may be due to the combination of distinct concepts of tolerability and interference with daily activities in a single, patient self‐reported rating question. 36 , 38 Despite being disease‐specific, validated and frequently used, the HDSS could be flawed in its interpretation.…”
Section: Discussionmentioning
confidence: 99%
“…This large variation in GSP is not surprising, because many factors influence GSP including diet, emotions, environmental conditions, and medication use, 19 and it has been suggested that GSP is not a good indicator of hyperhidrosis disease severity. 20,21 The data from this study emphasize the need for multiple assessments to confirm treatment effect. 19…”
Section: Discussionmentioning
confidence: 81%
“…In one study, it was found that you needed at least 23 patients pooled to observe a significant difference when measuring the effect of treatment 7 . In another study (the only other study of sufficient quality), it was observed that a single low gravimetric value was not necessarily indicative of a less severe disease 8 . Gravimetry captures a single 5‐minute snapshot which might fail to capture the full disease burden.…”
Section: Resultsmentioning
confidence: 99%
“…7 In another study (the only other study of sufficient quality), it was observed that a single low gravimetric value was not necessarily indicative of a less severe disease. 8 Gravimetry captures a single 5-minute snapshot which might fail to capture the full disease burden. The method can still be used to show differences between two groups receiving different treatments but not in the single patient.…”
Section: Diagnosticsmentioning
confidence: 99%