Comparison of patient dose from routine multi-phase and dynamic liver perfusion CT studies taking into account the effect of iodinated contrast administration

Perisinakis, Kostas; Tzedakis, Antonis; Pouli, Styliani; Spanakis, K.; Hatzidakis, Adam; Damilakis, John

doi:10.1016/j.ejrad.2018.11.015

Cited by 5 publications

(4 citation statements)

References 18 publications

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“…In most studies of routine CTA scanning of the aorta in patients with suspected interlining, the images are acquired 20-25 s after contrast medium injection; often for arterial hemodynamic changes, single-phase data may show little deviation or, because the blood ow velocity is slow, appear such as near the heart where imaging quality is higher, but the far heart end may have poor image quality [21][22][23]. In order to solve these problems, multiphase data can be acquired by dynamic scanning imaging within a range of 15-35 s to supplement the information missing in single-phase scanning.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic value of dynamic computed tomographic angiography for aortic dissection and the perfusion of involved organs

Song

Lyu

Wang

et al. 2022

Preprint

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Purpose: Early diagnosis of aortic dissection (AD) and end-organ malperfusion is of great significance for AD’s management and prognosis. This study aimed to evaluate the use of aortic dynamic computed tomography (CT) angiography (CTA) in diagnosing AD and the significance of evaluating blood supply to abdominal organs. Methods: The patients with confirmed AD and who visited our hospital from 12/2018 to 12/2019 were retrospectively included. The densities of the aortas and abdominal organs were measured, and a time-density curve was drawn and compared with conventional CTA. Correlation analysis was performed between the changes of densities in the false lumen and the changes of densities in injured kidneys. Results:Fifty patients were included. The tears were seen in 86%. The main aortic branches were involved in 48%. The diagnostic rate of dynamic angiography for rupture was 86%, slightly better than aortic CTA (84%, P<0.01; κ=0.765). The density of the true and false lumens was measured in each phase: phase 2 (4%), 3 (4%), 4 (48%), 5 (26%), and 6 (16%). Eighteen patients had single renal artery involvement. In phase 7, the density of the AD false lumen and kidney damage were correlated (r=0.75, P<0.001). Conclusions: Dynamic angiography can show the fine structures of AD. In dynamic angiography, the best phase can be selected according to the hemodynamic changes of patients to complete the diagnosis. False lumen density in phase 7 was correlated with renal injury.

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Section: Discussionmentioning

confidence: 99%

Diagnostic value of dynamic computed tomographic angiography for aortic dissection and the perfusion of involved organs

Song

Lyu

Wang

et al. 2022

Preprint

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“…Our aim in this work is to correlate between dose and image quality metrics in pediatric while implementing CT optimization protocols. Among radiation dose metrics, organ equivalent dose is considered one of the best indicators for characterizing patient radiation burden [10,32]. Several researchers have been inspired to reduce the risk by altering the variable of scan parameters, including growing the pitch factor, increasing slice collimation, choosing tube voltage, and utilizing automatic tube current modulation (ATCM) feature [33][34][35].…”

Section: Discussionmentioning

confidence: 99%

“…Recently, with growing involvement in radiation-induced cancer, this debate is again in the spotlight, as radiation exposure optimization is a particular problem in pediatric patients receiving repeated CT examination [6][7][8]. Despite the high frequency of CT procedure usage amongst children, radiation burden from CT examination needs to be considered as children are more sensitive to radiation as compared to adults [9,10]. Since 2007, the American College of Radiology (ACR), the Society for Pediatric Radiology (SPR), the American Association of Physicists in Medicine (AAPM), and the American Society of Radiology Technologists (ASRT) have engaged in the Image Gently campaign in the United States to grow the knowledge of practice by increasing awareness among radiation personnel [11,12].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Organ Dose and Image Quality Metrics of Pediatric CT Chest-Abdomen-Pelvis (CAP) Examination: An Anthropomorphic Phantom Study

et al. 2021

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The aim of this study is to investigate the impact of CT acquisition parameter setting on organ dose and its influence on image quality metrics in pediatric phantom during CT examination. The study was performed on 64-slice multidetector CT scanner (MDCT) Siemens Definition AS (Siemens Sector Healthcare, Forchheim, Germany) using various CT CAP protocols (P1–P9). Tube potential for P1, P2, and P3 protocols were fixed at 100 kVp while P4, P5, and P6 were fixed at 80 kVp with used of various reference noise values. P7, P8, and P9 were the modification of P1 with changes on slice collimation, pitch factor, and tube current modulation (TCM), respectively. TLD-100 chips were inserted into the phantom slab number 7, 9, 10, 12, 13, and 14 to represent thyroid, lung, liver, stomach, gonads, and skin, respectively. The image quality metrics, signal to noise ratio (SNR) and contrast to noise ratio (CNR) values were obtained from the CT console. As a result, this study indicates a potential reduction in the absorbed dose up to 20% to 50% along with reducing tube voltage, tube current, and increasing the slice collimation. There is no significant difference (p > 0.05) observed between the protocols and image metrics.

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“…Although CT may be cost-effective for HCC screening [ 10 ], it is considered to be unfavorable for surveillance purposes because of repetitive and thus cumulative radiation exposure. As imaging for HCC requires at least three phases, i.e., arterial, portal-venous, and delayed phases after intravenous contrast administration, the radiation dose is estimated to be around 20 mSv per examination [ 11 ]. Although, a recent meta-analysis found that a cumulative dose of 100 mSv and probably 200 mSv may not increase the risk of carcinogenesis for patients; this cumulative dose is reached within 5 years in the case of HCC surveillance [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Potential of a Non-Contrast-Enhanced Abbreviated MRI Screening Protocol (NC-AMRI) in High-Risk Patients under Surveillance for HCC

Willemssen

Sablonière

Bos

et al. 2022

Cancers

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Purpose: To evaluate NC-AMRI for the detection of HCC in high-risk patients. Methods: Patients who underwent yearly contrast-enhanced MRI (i.e., full MRI protocol) of the liver were included retrospectively. For all patients, the sequences that constitute the NC-AMRI protocol, namely diffusion-weighted imaging (DWI), T2-weighted (T2W) imaging with fat saturation, and T1-weighted (T1W) in-phase and opposed-phase imaging, were extracted, anonymized, and uploaded to a separate research server and reviewed independently by three radiologists with different levels of experience. Reader I and III held a mutual training session. Levels of suspicion of HCC per patient were compared and the sensitivity, specificity, and area under the curve (AUC) using the Mann–Whitney U test were calculated. The reference standard was a final diagnosis based on full liver MRI and clinical follow-up information. Results: Two-hundred-and-fifteen patients were included, 36 (16.7%) had HCC and 179 (83.3%) did not. The level of agreement between readers was reasonable to good and concordant with the level of expertise and participation in a mutual training session. Receiver operating characteristics (ROC) analysis showed relatively high AUC values (range 0.89–0.94). Double reading showed increased sensitivity of 97.2% and specificity of 87.2% compared with individual results (sensitivity 80.1%–91.7%–97.2%; specificity 91.1%–72.1%–82.1%). Only one HCC (2.8%) was missed by all readers. Conclusion: NC-AMRI presents a good potential surveillance imaging tool for the detection of HCC in high-risk patients. The best results are achieved with two observers after a mutual training session.

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Comparison of patient dose from routine multi-phase and dynamic liver perfusion CT studies taking into account the effect of iodinated contrast administration

Cited by 5 publications

References 18 publications

Diagnostic value of dynamic computed tomographic angiography for aortic dissection and the perfusion of involved organs

Diagnostic value of dynamic computed tomographic angiography for aortic dissection and the perfusion of involved organs

Evaluation of Organ Dose and Image Quality Metrics of Pediatric CT Chest-Abdomen-Pelvis (CAP) Examination: An Anthropomorphic Phantom Study

Potential of a Non-Contrast-Enhanced Abbreviated MRI Screening Protocol (NC-AMRI) in High-Risk Patients under Surveillance for HCC

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