Comparison of patient-controlled sedation with either methohexitone or propofol

Abstract

We studied 42 patients undergoing oral surgery under local anaesthesia with i.v. sedation, allocated randomly to receive either methohexitone (group M) or propofol (group P) for patient-controlled sedation (PCS). Group M patients self-administered 2.5-mg (0.5 ml) bolus doses of methohexitone and group P, 5-mg (0.5 ml) doses of propofol, without a lockout. The 0.5-ml bolus dose was delivered over 7.2 s for both drugs. The procedure was completed satisfactorily in all patients. Patients in both groups achieved their desired levels of sedation. No patient lost verbal contact. Group M patients had higher heart rates during the procedure. The lowest SpO2 values recorded were 92% and 95% for group P and group M, respectively. Immediately after operation patients in group M reported that they felt more sleepy than those in group P (P < 0.01) but there were no differences at subsequent times. The results of the psychomotor tests were comparable for the two groups after operation, except for the "posting box task" at 15 min after operation when the mean decrement (compared with preoperative performance) was -3% for group P and -13% for group M (P < 0.05). More patients in group P complained of pain in their hand. We conclude that methohexitone is a suitable alternative drug to propofol for PCS.

Propofol intravenous conscious sedation for anxious children in a specialist paediatric dentistry unit

“…higher levels of sedation during local anaesthesia injections or tooth extractions after which much lower levels of sedation can be used. Infusion of propofol by target-controlled infusion (TCI) or patient controlled infusion systems have already been reported to be effective in achieving conscious sedation not only for anxious adults presenting for dental surgery but also for those with learning disability [30][31][32][33][34][35][36][37]. Veerkamp et al .…”

Managing anxious children: the use of conscious sedation in paediatric dentistry

“…the dose required to produce a sedative effect is close to that used to induce anaesthesia. Infusion pumps are used to control the dose, and patient controlled systems are currently in development, which have been used with some success in adult patients [87–93]. Veerkamp et al .…”

UK National Clinical Guidelines in Paediatric Dentistry*

“…the dose required to produce a sedative effect is close to that used to induce anaesthesia. Infusion pumps are used to control the dose, and patient controlled systems are currently in development, which have been used with some success in adult patients [87][88][89][90][91][92][93]. Veerkamp et al .…”