Comparison of parameters affecting GNP-loaded choroidal melanoma dosimetry; Monte Carlo study

Sharabiani, M.; Asadi, Somayeh; Barghi, A. Rahnamai; Vaezzadeh, Majid

doi:10.1016/j.radphyschem.2017.10.021

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…The concentration of DEF liquid is 2.45 % at 30 mg and 0.7 % at 7 mg [8]. In another study [9], four different concentrations and different volumes were use in eye and water phantoms. A Monte Carlo code was used to evaluate the effects of these concentrations and volumes on the dose that the tumor receives when a high-energy source is used.…”

Section: Introduction mentioning

confidence: 99%

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Investigation of Tissue Components Impacts on Dose Enhancement Factor Using Monte Carlo Code

AL-suhbani,

Baghous,

Serag

et al. 2024

Atom Indo.

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Despite the progress of science in cancer treatments and radiotherapy improvements, there are still several side effects that occur during tumors treatment, particularly on healthy tissues surrounded tumors. Newer treatment methods are being explored lately, one of which is the use of nanoparticles, wherein the tumor is injected with gold nanoparticles. Its aim is to enhance tumor sensitivity to radiation and reduce radiation damage to healthy tissues. Tissue type may play an effective role in enhancing the dose being received under the use of nanoparticles. This study aims to find the effect of different tissue components on dose enhancement factor through MCNP6 and GATE simulations, as well as to accurately compare the simulation results of these two code packages for dose enhancement factors. A 125I brachytherapy source was simulated in phantoms for five tissues or materials (adipose tissue, breast tissue, soft tissue, water, and brain tissue). MCNP6 simulation code was validated by comparing its results with a previous study by Cho et al. Gold nanoparticles were injected as a mixture at a concentration of 7 mg/g into tissues inside a tumor. MCNP6 and GATE simulation results were compared. It was estimated from MCNP simulations that the highest radiation dose enhancement of 2.34 occurs in adipose tissue while lowest dose enhancement of 1.69 is in brain. In comparison, from GATE results, the estimates were that the highest value of dose enhancement factor also occurred in adipose tissue at 2.01, and the lowest value in brain at 1.48. The comparison between two codes suggest that they are compatible with the percentage difference in all tissues being less than 15 %. This study confirms that both MCNP6 and GATE codes could calculate DEF for different tissues under irradiation from a low-energy source.

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Section: Introduction mentioning

confidence: 99%

“…This study concluded that at a concentration of 30 mg and a volume of 100 nm, the eye structure is optimal. To obtain the highest dose sedimentation level for nanoparticles, therefore, the size and concentration of GNPs are considered as factors to increase the macroscopic dose in choroidal melanoma [9].…”

Section: Introduction mentioning

confidence: 99%

Investigation of Tissue Components Impacts on Dose Enhancement Factor Using Monte Carlo Code

AL-suhbani,

Baghous,

Serag

et al. 2024

Atom Indo.

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Monte Carlo simulations for dose enhancement in cancer treatment using bismuth oxide nanoparticles implanted in brain soft tissue

Taha

Djouider

Banoqitah

2018

Australas Phys Eng Sci Med

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The objective of this work is to study the dosimetric performances of bismuth oxide nanoparticles implanted in tumors in cancer radiotherapy. GEANT4 based Monte Carlo numerical simulations were performed to assess dose enhancement distributions in and around a 1 × 1 × 1 cm tumor implanted with different concentrations of bismuth oxide and irradiated with low energies I,Cs, and Pd radioactive sources. Dose contributions were considered from photoelectrons, Auger electrons, and characteristic X-rays. Our results show the dose enhancement increased with increasing both bismuth oxide concentration in the target and photon energy. A dose enhancement factor up to 18.55 was obtained for a concentration of 70 mg/g of bismuth oxide in the tumor when irradiated withCs source. This study showed that bismuth oxide nanoparticles are innovative agents that could be potentially applicable to in vivo cancer radiotherapy due to the fact that they induce a highly localized energy deposition within the tumor.

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Monte Carlo study of nanoparticles effectiveness on the dose enhancement when irradiated by protons

Ganjeh

Salehi

2023

AIP Advances

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Recently, the nanomedicine field has experienced considerable growth in research. The use of nanoparticles to enhance dose in radiation treatment was proposed and their potential effects can be indicated using Monte Carlo calculations. The main goal of this study focused on nanoparticles’ (NPs) effects on dose enhancement due to the low-energy protons because the majority of studies on NPs have been conducted for photon radiations. To investigate the effect of NPs on the Dose Enhancement Factor (DEF), a cell dimension phantom was modeled and spheres of NPs were localized inside that. Different NPs, such as Au, Pt, Ag, I, and Ta2O3, were located in the phantom, and the DEF was calculated by changing the source energy from 3 to 15 MeV. The purpose of investigating the low-energy proton beam is to clarify the effects around the Bragg peak in the presence of nanoparticles. For protons with an energy range of 3–15 MeV, it was discovered that Pt nanoparticles have a greater dose increase coefficient of about 1.8 times compared to the other nanoparticles. The findings indicated that the DEF values substantially depended on the NPs concentration, but that the DEF was not significantly affected by changes in concentration or nanoparticle size. Comparative calculations between water and soft tissue phantoms that were filled with NPs presented a difference of less than 2%. The obtained findings emphasized the importance of NPs and considered details, such as concentration, to demonstrate the potential of nanoparticles in improving treatment using protons.

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Comparison of parameters affecting GNP-loaded choroidal melanoma dosimetry; Monte Carlo study

Cited by 3 publications

References 21 publications

Investigation of Tissue Components Impacts on Dose Enhancement Factor Using Monte Carlo Code

Investigation of Tissue Components Impacts on Dose Enhancement Factor Using Monte Carlo Code

Monte Carlo simulations for dose enhancement in cancer treatment using bismuth oxide nanoparticles implanted in brain soft tissue

Monte Carlo study of nanoparticles effectiveness on the dose enhancement when irradiated by protons

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