Comparison of palonosetron and dexamethasone with ondansetron and dexamethasone for postoperative nausea and vomiting in postchemotherapy ovarian cancer surgeries requiring opioid-based patient-controlled analgesia: A randomised, double-blind, active controlled study

Kumar, Amit; Solanki, Sohan Lal; Gangakhedkar, Gauri R; Shylasree, TS; Sharma, Kailash S.

doi:10.4103/ija.ija_437_18

Cited by 16 publications

(4 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Compared with the palonosetron group, the severity of nausea at 0 to 6 hours after operation in the palonosetron + dexamethasone group was significantly lower (no/mild/moderate/severe: 49/22/15/10 vs 36/16/25/19, P = .008). Amit Kumar et al [ 37 ] reported palonosetron with dexamethasone is more effective than ondasetron with dexamethasone for prevention of PONV in post-chemotherapy ovarian cancer surgeries receiving opioid-based patient-controlled analgesia. Anish n g Sharma et al [ 38 ] found that among patients undergoing elective laparoscopic hysterectomy under general anesthesia, palonosetron combined with dexamethasone is more effective in the treatment of early, delayed and long-term PONV than ondansetron combined with dexamethasone.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety analysis of dexamethasone + palonosetron in prevention of post-embolization syndrome after D-TACE: A retrospective study

Lu,

Zheng,

Liang

et al. 2023

Medicine

View full text Add to dashboard Cite

To investigate the efficacy and safety of dexamethasone + palonosetron in the prevention of post-embolization syndrome after drug-eluting beads transcatheter arterial chemoembolization (D-TACE). The data of 278 patients who received D-TACE from January 2018 to December 2021 were collected and divided into 2 groups: D-TACE group (N = 145) and D-TACE + dexamethasone + palonosetron group (N = 133). The incidence of post-embolization syndrome and infection after D-TACE was assessed in both groups. Incidence of abdominal pain: D-TACE group versus D-TACE + dexamethasone + palonosetron group, 56.6% versus 40.6%, P = .008; incidence of fever: D-TACE group versus D-TACE + dexamethasone + palonosetron group, 40.0% versus 14.3%, P = .000; incidence of nausea: D-TACE group versus D-TACE + dexamethasone + palonosetron group, 61.4% versus 39.8%, P = .001; incidence of vomiting: D-TACE group versus D-TACE + dexamethasone + palonosetron group, 48.3% versus 21.1%, P = .000; incidence of infection: D-TACE group versus D-TACE + dexamethasone + palonosetron group, 1.4% versus 1.5%, P = .931. The combined use of dexamethasone and palonosetron before D-TACE can effectively reduce the incidence of post-embolization syndrome and reduce the degree of side effects, but it will not increase the risk of infection.

show abstract

Section: Discussionmentioning

confidence: 99%

Efficacy and safety analysis of dexamethasone + palonosetron in prevention of post-embolization syndrome after D-TACE: A retrospective study

Lu,

Zheng,

Liang

et al. 2023

Medicine

View full text Add to dashboard Cite

show abstract

“…Only 8.75% of the patients in our study received postoperative opioid analgesics, which is an important risk factor for PONV. Several studies [2,23,24] that found a higher incidence of PONV reported that patients used postoperative opioids more frequently. In our study, the type of surgery was associated with a low pain score; thus, the low postoperative opioid consumption may have led to a lower incidence of PONV.…”

Section: Discussionmentioning

confidence: 99%

A prospective, randomized, double-blind trial to compare body weight-adjusted and fixed doses of palonosetron for preventing postoperative nausea and vomiting in obese female patients

et al. 2020

View full text Add to dashboard Cite

Background Postoperative nausea and vomiting (PONV) is a common postsurgical complication. Palonosetron is effective for PONV prevention at the usual dose of 75 μg, but the ideal dose for obese patients has not yet been investigated. The aim of this study was to compare body weight-adjusted and fixed doses of palonosetron for preventing PONV in obese female patients. Materials and methods We performed a prospective, randomized, double-blind trial involving 80 female patients, aged 18-80 years with an American Society of Anesthesiologists physical status of 2 and 3 and a body mass index (BMI) � 30 kg m-2 who were scheduled to undergo elective breast surgery. Patients received an intravenous body weight-adjusted dose of palonosetron (1 μg kg-1 , GI = 40 patients) or a fixed dose of palonosetron (75 μg, GII = 40 patients). All patients received dexamethasone (4 mg). The incidence of PONV, complete response rate (CR), severity of nausea and need for rescue antiemetics and analgesics were assessed at: 0-1 h, 1-6 h, 6-24 h and 24-48 h postoperatively. Results The mean (± SD) BMI was 35.0 (±5.2) kg m-2 for GI and 35.7 (±3.6) kg m-2 for GII. There was no significant difference between groups in PONV incidence, CR, severity of nausea,

show abstract

“…It also avoids all side effects of ramosetron, palanosetron, dexamethasone and even ephedrine which are being tried in newer studies. [11][12][13]…”

Section: Discussionmentioning

confidence: 99%

Comparison of ondansetron versus chewing gum for prevention of post operative nausea and vomiting in patients undergoing elective LSCS: A randomised control trial

Madhumala¹,

Rohit²,

M³

et al. 2020

IJCA

View full text Add to dashboard Cite

Background: Pregnant women are always considered full stomach with high incidence of nausea and vomiting. Anti-emetic efficacy of Ondansetron has been proved in various studies. The aim of this present study is to evaluate efficacy and safety of chewing gum as an alternative to Ondansetron in prevention of postoperative nausea and vomiting (PONV) in parturients undergoing elective LSCS under spinal anesthesia. Materials and Methods: One hundred pregnant women who were found eligible as per inclusion and exclusion criteria were randomized into two equal groups by simple randomization into Group A (n=50) who were given sugar free chewing gum which was to be chewed for 30 minutes three times a day starting immediately after cesarean section and Group B (n=50) who received Inj. Ondanse tron 4mg twice a day post operatively. The outcome measures were episodes of post-operative nausea and vomiting at 6, 12, 18 and 24 hours in both groups, relief of PONV and acceptability of treatment. The secondary outcome measures time to first flatus. Statistical analysis was done through relevant tests using SPSS 16.0. Results: There was no statistically significant difference between the two groups in terms of demographic characteristics such as age, gravidity parity, duration of surgery and type of cesarean section. The incidence of nausea and vomiting was significantly less in Group A compared with Group B at 6 and 12 hours post operatively (p < 0.001). There was no significant difference of this variable at 18 and 24 hours in both groups. The mean average of the first passage of flatus in group A was 20.3±2.01 hours versus 29.6±2.51 hours in Group B (P<0.0001) was significantly shorter compared to the group B. Conclusion: Gum chewing after cesarean section is safe, well tolerated, and acceptable for prevention of post-operative nausea and vomiting and rapid resumption of intestinal motility and has potential impact on reducing the overall healthcare costs in case of routine implementation.

show abstract

Comparison of palonosetron and dexamethasone with ondansetron and dexamethasone for postoperative nausea and vomiting in postchemotherapy ovarian cancer surgeries requiring opioid-based patient-controlled analgesia: A randomised, double-blind, active controlled study

Cited by 16 publications

References 22 publications

Efficacy and safety analysis of dexamethasone + palonosetron in prevention of post-embolization syndrome after D-TACE: A retrospective study

Efficacy and safety analysis of dexamethasone + palonosetron in prevention of post-embolization syndrome after D-TACE: A retrospective study

A prospective, randomized, double-blind trial to compare body weight-adjusted and fixed doses of palonosetron for preventing postoperative nausea and vomiting in obese female patients

Comparison of ondansetron versus chewing gum for prevention of post operative nausea and vomiting in patients undergoing elective LSCS: A randomised control trial

Contact Info

Product

Resources

About