Comparison of Pain-relieving Effects of Fentanyl versus Ketorolac after Eye Amputation Surgery

Kim, Jin Hyung; Jang, Sun Young; Kim, Myung Jin; Lee, Sang Yeul; Yoon, Jin Sook

doi:10.3341/kjo.2013.27.4.229

Cited by 15 publications

(12 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Currently, opioid-based IV-PCA is widely used for postoperative pain control due to its short action duration and strong analgesic effect. However, opioid-based IV-PCA is also associated with several adverse effects, for example, postoperative nausea and vomiting (PONV), dizziness, decreased blood pressure, and urinary retention [ 2 , 3 , 4 , 5 , 6 ]. These adverse effects are not easily avoided using multimodal preventive approaches.…”

Section: Introductionmentioning

confidence: 99%

Can intravenous patient-controlled analgesia be omitted in patients undergoing laparoscopic surgery for colorectal cancer?

Choi

Park

et al. 2015

Ann Surg Treat Res

View full text Add to dashboard Cite

PurposeOpioid-based intravenous patient-controlled analgesia (IV-PCA) is a popular method of postoperative analgesia, but many patients suffer from PCA-related complications. We hypothesized that PCA was not essential in patients undergoing major abdominal surgery by minimal invasive approach.MethodsBetween February 2013 and August 2013, 297 patients undergoing laparoscopic surgery for colorectal cancer were included in this retrospective comparative study. The PCA group received conventional opioid-based PCA postoperatively, and the non-PCA group received intravenous anti-inflammatory drugs (Tramadol) as necessary. Patients reported their postoperative pain using a subjective visual analogue scale (VAS). The PCA-related adverse effects and frequency of rescue analgesia were evaluated, and the recovery rates were measured.ResultsPatients in the PCA group experienced less postoperative pain on days 4 and 5 after surgery than those in the non-PCA group (mean [SD] VAS: day 4, 6.2 [0.3] vs. 7.0 [0.3], P = 0.010; and day 5, 5.1 [0.2] vs. 5.5 [0.2], P = 0.030, respectively). Fewer patients in the non-PCA group required additional parenteral analgesia (41 of 93 patients vs. 53 of 75 patients, respectively), and none in the non-PCA group required rescue PCA postoperatively. The incidence of postoperative nausea and vomiting was significantly higher in the non-PCA group than in the PCA group (P < 0.001). The mean (range) length of hospital stay was shorter in the non-PCA group (7.9 [6-10] days vs. 8.7 [7-16] days, respectively, P = 0.03).ConclusionOur Results suggest that IV-PCA may not be necessary in selected patients those who underwent minimal invasive surgery for colorectal cancer.

show abstract

Section: Introductionmentioning

confidence: 99%

Can intravenous patient-controlled analgesia be omitted in patients undergoing laparoscopic surgery for colorectal cancer?

Choi

Park

et al. 2015

Ann Surg Treat Res

View full text Add to dashboard Cite

show abstract

“…4 While opioids have proven effective analgesics in a wide range of ophthalmic settings, attention is turning to how they are used in ophthalmology. [5][6][7][8][9][10] Patel and Sternberg 11 conducted a study characterizing opioid-prescription patterns by ophthalmologists within Medicare. They showed that about 90% of ophthalmologists wrote fewer than 10 opioid prescriptions annually, and approximately 1% wrote more than 100 prescriptions annually.…”

mentioning

confidence: 99%

Association of Opioids With Incisional Ocular Surgery

Kolomeyer

VanderBeek

2019

JAMA Ophthalmol

View full text Add to dashboard Cite

he last few decades have seen a considerable increase in opioid-associated deaths in the United States. As per the US Centers for Disease Control and Prevention, more than 200 000 people have died from opioidassociated overdoses in the United States from 1999 through 2016, with 5 times more people dying from prescription opioids in 2016 than in 1999; in US adults younger than 50 years, drug overdose has become the number 1 cause of mortality, and the rates are higher in men than women and higher in non-Hispanic white individuals than other racial/ethnic groups. 1,2 In addition, the rates are increasing in the older population as well. 3 This prompted the establishment of a 5-point plan to combat opioid abuse, misuse, and overdose by the US Department of Health and Human Services in 2017. 4 While opioids have proven effective analgesics in a wide range of ophthalmic settings, attention is turning to how they are used in ophthalmology. [5][6][7][8][9][10] Patel and Sternberg 11 conducted a study characterizing opioid-prescription patterns by ophthalmologists within Medicare. They showed that about 90% of ophthalmologists wrote fewer than 10 opioid prescriptions annually, and approximately 1% wrote more than 100 prescriptions annually. Charlson and coworkers 12 specifically focused on oculoplastic surgeons and found that they wrote a mean of 45 opioid prescriptions per year, with 45% writing fewer than 10 and 14.8% writing IMPORTANCE Opioid abuse has been declared a public health emergency. Currently, little is known about the association between opioids and ocular surgery. OBJECTIVE To characterize rates of filled opioid prescriptions after incisional ocular surgeries. DESIGN, SETTING, AND PARTICIPANTSThis cohort study included patients with incisional ocular surgeries within a large national US insurer's administrative medical claims database. All incisional ocular surgeries from January 2000 through December 2016 were evaluated. An opioid prescription was eligible if it occurred from 1 day before to 7 days after a surgery. Any surgery on a patient who was younger than 18 years, had more than 30 consecutive days of an opioid prescription in the prior 6 months, or had less than 6 months of data in the database prior to surgery was excluded. Data analysis occurred from May 2018 through November 2018. MAIN OUTCOMES AND MEASURESThe rate of opioid prescriptions filled for all incisional ocular surgeries from 2000 through 2016. Primary analysis looked at the rate of filled opioid prescriptions for each ophthalmic subspecialty surgery over time. Secondary analysis assessed which patient or surgical characteristics (ie, age, sex, race/ethnicity, geographic locations, yearly income, educational level, and type of eye surgery) were associated with filling an opioid prescription. Multivariate logistic regression using generalized estimating equations was used to determine odds ratios (ORs) of filling an opioid prescription.RESULTS A total of 2 407 962 incisional ocular surgeries were included, of which 45 776 (1.90%) were as...

show abstract

“…4 Given its unique analgesic potency, PCA with FC is widely used to manage postoperative, gynaecologic, and obstetric pain in clinical patients, but it also has serious adverse reactions (ADRs), such as postoperative nausea and vomiting (PONV), dizziness, hypotension, pruritus, and respiratory depression. 5 , 6 Naloxone hydrochloride (NH, Figure 1B , (5α)-4,5- epoxy-3,14-dihydroxy-17-(2-propen-1-yl) morphinan-6-one, is an easy-to-use opioid antagonist analgesic that binds to opioid receptors but does not affect the receptors themselves. 7 , 8 It has been reported in recent years that a small amount of naloxone as an adjuvant to an opioid can help to reduce the requirements for and potential adverse effects of the opioid.…”

Section: Introductionmentioning

confidence: 99%

<p>Physical Compatibility and Chemical Stability of Fentanyl and Naloxone Hydrochloride in 0.9% Sodium Chloride Injection Solution for Patient-Controlled Analgesia Administration</p>

Chen

Lei

et al. 2020

DDDT

View full text Add to dashboard Cite

Background and Objective: The combination of naloxone hydrochloride (NH) and fentanyl citrate (FC) in patient-controlled analgesia (PCA) is examined to reduce the risk of opioid-induced nausea and vomiting. However, there are no such commercially available drug mixtures, and there is also no published evidence on the compatibility and stability of NH and FC. Thus, the primary purpose of the current research is to investigate the physical compatibility and chemical stability of NH when mixed with FC over a 72-h period in a 0.9% sodium chloride injection solution for PCA administration under storage at 4°C and 25°C. Methods: Test solutions of 20 μg/mL FC and 4 μg/mL NH were prepared and stored in polyvinyl chloride (PVC) bags or glass bottles with a 0.9% sodium chloride injection solution as the diluent. During the 72-h storage period at 4°C or 25°C without light protection, the concentrations of the test drugs were assayed via high-performance liquid chromatography (HPLC), and the physical compatibility was determined with the naked eye. Furthermore, pH measurement of each sample was also performed with a pH meter. Results: The percentages of the initial concentrations of FC and NH in the various solutions were maintained at a minimum of 98% over the 72-h study period. All of the mixtures remained clear and colourless throughout the observation period, and no precipitation or turbidity was observed in any of the batches. Conclusion: The 20 μg/mL FC test solution was physically compatible and chemically stable with the 4 μg/mL NH test solution when stored at 4°C or 25°C in PVC bags or glass bottles containing the 0.9% sodium chloride injection solution.

show abstract

Comparison of Pain-relieving Effects of Fentanyl versus Ketorolac after Eye Amputation Surgery

Cited by 15 publications

References 24 publications

Can intravenous patient-controlled analgesia be omitted in patients undergoing laparoscopic surgery for colorectal cancer?

Can intravenous patient-controlled analgesia be omitted in patients undergoing laparoscopic surgery for colorectal cancer?

Association of Opioids With Incisional Ocular Surgery

<p>Physical Compatibility and Chemical Stability of Fentanyl and Naloxone Hydrochloride in 0.9% Sodium Chloride Injection Solution for Patient-Controlled Analgesia Administration</p>

Contact Info

Product

Resources

About