Comparison of Oxidative<scp>DNA</scp>Damage Between Alcohol‐Dependent Patients With and Without Delirium Tremens

Huang, Ming; Chen, Chiao Chicy; Pan, Chun‐Hung; Chen, Chun Hsin

doi:10.1111/acer.12539

Cited by 11 publications

(5 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Details of the search results are presented in eFigure 1 in the Supplement. We identified 82 studies fulfilling the inclusion criteria, comprising 205 patient vs control group comparisons and a total of 10 151 patient and 10 532 control observations. Seven studies had interventions, comprising a total of 15 preintervention-postintervention comparisons.…”

Section: Resultsmentioning

confidence: 99%

“…We identified 82 studies fulfilling the inclusion criteria, comprising 205 patient vs control group comparisons and a total of 10 151 patient and 10 532 control observations. Seven studies had interventions, comprising a total of 15 preintervention-postintervention comparisons. Included studies and their covariates are presented in eTable 2 (cross-sectional) and eTable 3 (interventions) in the Supplement.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Association of Oxidative Stress–Induced Nucleic Acid Damage With Psychiatric Disorders in Adults

et al. 2022

View full text Add to dashboard Cite

IMPORTANCE Nucleic acid damage from oxidative stress (NA-OXS) may be a molecular mechanism driving the severely increased morbidity and mortality from somatic causes in adults with psychiatric disorders.OBJECTIVE To systematically retrieve and analyze data on NA-OXS across the psychiatric disorder diagnostic spectrum.DATA SOURCES The PubMed, Embase, and PsycINFO databases were searched from inception to November 16, 2021. A hand search of reference lists of relevant articles was also performed.STUDY SELECTION Key study inclusion criteria in this meta-analysis were as follows: adult human study population, measurement of any marker of DNA or RNA damage from oxidative stress, and either a (1) cross-sectional design comparing patients with psychiatric disorders (any diagnosis) with a control group or (2) prospective intervention. Two authors screened the studies, and 2 senior authors read the relevant articles in full and assessed them for eligibility. DATA EXTRACTION AND SYNTHESISThe Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines were followed. Two authors performed data extraction independently, and a senior coauthor was consulted in cases of disagreement. Data were synthesized with random-effects and multilevel meta-analyses. MAIN OUTCOMES AND MEASURESThe predefined hypothesis was that individuals with psychiatric disorders have increased NA-OXS levels. The main outcome was the standardized mean differences (SMDs) among patients and controls in nucleic acid oxidation markers compared across diagnostic groups. Analyses were divided into combinations of biological matrices and nucleic acids.RESULTS Eighty-two studies fulfilled the inclusion criteria, comprising 205 patient vs control group comparisons and a total of 10 151 patient and 10 532 control observations. Overall, the data showed that patients with psychiatric disorders had higher NA-OXS levels vs controls across matrices and molecules. Pooled effect sizes ranged from moderate for urinary DNA markers (SMD = 0.44 [95% CI, 0.20-0.68]; P < .001) to very large for blood cell DNA markers (SMD = 1.12 [95% CI, 0.69-1.55; P < .001). Higher NA-OXS levels were observed among patients with dementias followed by psychotic and bipolar disorders. Sensitivity analyses excluding low-quality studies did not materially alter the results. Intervention studies were few and too heterogenous for meaningful meta-analysis. CONCLUSIONS AND RELEVANCEThe results of this meta-analysis suggest that there is an association with increased NA-OXS levels in individuals across the psychiatric disorder diagnostic spectrum. NA-OXS may play a role in the somatic morbidity and mortality observed among individuals with psychiatric disorders.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Association of Oxidative Stress–Induced Nucleic Acid Damage With Psychiatric Disorders in Adults

et al. 2022

View full text Add to dashboard Cite

show abstract

“…They reported that the oxidative DNA damage persisted after 1 week of detoxification and that the alcohol withdrawal severity was correlated with the increase in oxidative stress, particularly the 8-OHdG levels [ 59 ]. In a later study, the authors investigated oxidative DNA damage between AD patients with and without delirium tremens, using 8-OHdG as a biomarker in AD patients with and without delirium tremens and reported that AD patients with delirium tremens have higher serum 8-OHdG levels than those without delirium tremens, suggesting that higher oxidative stress carries a greater risk of the occurrence of delirium tremens [ 60 ].…”

Section: Resultsmentioning

confidence: 99%

Alcohol-Induced Oxidative Stress and the Role of Antioxidants in Alcohol Use Disorder: A Systematic Review

2022

View full text Add to dashboard Cite

Alcohol use disorder (AUD) is a highly prevalent, comorbid, and disabling disorder. The underlying mechanism of ethanol neurotoxicity and the involvement of oxidative stress is still not fully elucidated. However, ethanol metabolism has been associated with increased oxidative stress through alcohol dehydrogenase, the microsomal ethanol oxidation system, and catalase metabolic pathways. We searched the PubMed and genome-wide association studies (GWAS) catalog databases to review the literature systematically and summarized the findings focusing on AUD and alcohol abstinence in relation to oxidative stress. In addition, we reviewed the ClinicalTrials.gov resource of the US National Library of Medicine to identify all ongoing and completed clinical trials that include therapeutic interventions based on antioxidants. The retrieved clinical and preclinical studies show that oxidative stress impacts AUD through genetics, alcohol metabolism, inflammation, and neurodegeneration.

show abstract

“…GSH functions as an important antioxidant barrier in the lung tissues in protection of cells against damage caused by oxidants. The 8-OHdG is a sensitive biomarker [43, 44] that is often used to evaluate DNA damage caused by ROS. 4-HNE, which is a product of oxidative damage, is a marker of lipid peroxidation [45, 46].…”

Section: Discussionmentioning

confidence: 99%

Recuperating Lung Decoction Attenuates the Oxidative Stress State of Chronic Obstructive Pulmonary Disease by Inhibiting the MAPK/AP‐1 Signal Pathway and Regulating γ‐GCS

Shi

Yan

et al. 2017

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Purpose/Objective. To evaluate the effects of Recuperating Lung Decoction (RLD) on the indices of oxidative stress in a rat model of COPD and detect the indices of the MAPK/AP-1/γ-GCS signal pathway for a further survey of the possible targeting site of RLD. Methods/Materials. The rats of COPD were treated with RLD. The protein levels of glutathione (GSH), oxidized glutathione (GSSG), 8-hydroxy-2-deoxyguanosine (8-OHdG), and 4-hydroxynonenal (4-HNE) were measured. In addition, the levels of key signaling molecules (extracellular signal-regulated kinases [ERK], the c-jun N-terminal kinase [JNKs signal pathway], and p38 MAP kinase [p38MAPK], AP-1 proteins [C-fos, C-jun], and γ-glutamyl-cysteine synthetase [γ-GCS-h]) of the MAPK/AP-1/γ-GCS-h signal pathway were assessed. Results. After treatment, the protein level of GSH and the ratio of GSH/GSSG were increased and the amounts of 8-OHdG and 4-HNE were decreased significantly in lung tissues when compared with the nontreated COPD group. Further results showed that the RLD could effectively inhibit the MAPK pathway by inactivation of p38MAPK and ERK and could also downregulate the AP-1 and the γ-GCS-h genes expressions in both protein and mRNA levels. Conclusion. RLD might improve the state of oxidative stress by downregulation of the expression of γ-GCS-h gene by inhibition of the MAPK/AP-1 pathway, thereafter enhancing the ability of antioxidation in COPD.

show abstract

Comparison of OxidativeDNADamage Between Alcohol‐Dependent Patients With and Without Delirium Tremens

Abstract: Alcohol-dependent patients with DTs have higher serum 8-OHdG levels than those without DTs, suggesting that higher oxidative stress carries a greater risk of the occurrence of DTs.

Cited by 11 publications

References 38 publications

Association of Oxidative Stress–Induced Nucleic Acid Damage With Psychiatric Disorders in Adults

Association of Oxidative Stress–Induced Nucleic Acid Damage With Psychiatric Disorders in Adults

Alcohol-Induced Oxidative Stress and the Role of Antioxidants in Alcohol Use Disorder: A Systematic Review

Recuperating Lung Decoction Attenuates the Oxidative Stress State of Chronic Obstructive Pulmonary Disease by Inhibiting the MAPK/AP‐1 Signal Pathway and Regulating γ‐GCS

Contact Info

Product

Resources

About