Comparison of oxidative metabolism in starved, fat-fed and carbohydrate-fed rats

Mayes, Peter A.; Felts, J.M.

doi:10.1042/bj1030400

Cited by 22 publications

(10 citation statements)

References 18 publications

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“…Any differences arising could of course be due to preexisting biological dispositions or to an adaptation resulting from long-term exposure of the body to large quantities of consumed fat. Whatever the mechanism, such differences should be expected since animal studies have indicated distinct changes in oxidative metabolism 16 and speci®c metabolism of fats 17 in rats fed high-fat diets.…”

Section: Introductionmentioning

confidence: 99%

Differences in energy expenditure and substrate oxidation between habitual high fat and low fat consumers (phenotypes)

Cooling

Blundell

1998

Int J Obes

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OBJECTIVE: To investigate physiological differences between habitual high-fat (HF) and low-fat (LF) consumers, which could in¯uence the balance between energy expenditure and energy intake, and the potential for weight gain. SUBJECTS: 16 young, lean males (eight HF and eight LF consumers; % energy from fat 44.3 and 32.0, respectively). MEASUREMENTS: Habitual dietary variables (from FFQ), body mass index (BMI), body fat % (measured by impedance), resting metabolic rate (RMR) (indirect calorimetry), substrate oxidation and basal heart rate, postprandial thermogenesis and heart rate in response to a high-fat (low carbohydrate (CHO)) and high-CHO (low fat) challenge. RESULTS: HF and LF (selected for their intake of fat) did not differ signi®cantly in BMI or % body fat. HF had a signi®cantly higher RMR (1624 vs 1455 kcalad) and basal heart rate (66 vs 57 bpm) than LF. Differences in oxygen utilisation and heart rate were maintained over a 180 min period, following the high-fat and high-CHO challenge meals. HF had a signi®cantly lower resting respiratory quotient (RQ) than LF and the differences in average RQ were signi®cant over the 180 min examination period. HF had a signi®cantly lower RQ response to the high fat (low CHO) than to the high CHO (low fat) challenge; this effect was not observed in LF. HF had higher total energy intake than LF and a higher absolute (but not %) intake of protein. CONCLUSION: Signi®cant differences in basal energy expenditure and fat oxidation between habitual HF and LF consumers have been observed. The contributions of energy intake and protein intake (g not %) remain to be determined. In this particular group of subjects (young adult males) a high energy intake characterised by a large fat component is associated with metabolic adaptations which could offset the weight inducing properties of a high-fat diet. These physiological differences may be important when considering the relationship between dietary-fat and obesity.

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Section: Introductionmentioning

confidence: 99%

Differences in energy expenditure and substrate oxidation between habitual high fat and low fat consumers (phenotypes)

Cooling

Blundell

1998

Int J Obes

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“…Mc Calla, Gates et notamment, ont montré qu'une heure après l'injection intraveineuse de palmitate marqué, près de 40 % de la dose injectée étaient excrétés sous forme de Mayes et Felts (1967) (Hagenfeldt et Wahren, 1968) ; il ne sera donc éliminé que très lentement au cours du temps. L'excrétion à 100 % de la dose pourrait prendre un temps extrêmement long par rapport à la durée de l'obser vation.…”

Section: B Metabolisme Oxydatif Du Rat Nephrotique In Totounclassified

“…Considérons d'abord le métabolisme du glucose chez le rat normal. Mayes et Felts (1967) observaient une excrétion cumulative en 180 minutes de 34,4 % de la dose de glucose-U-C^^ injectée chez le rat normal à jeûn depuis 48 heures. Nos valeurs (pour des rats à jeûn depuis 22 heures) sont très comparables à celles de ces auteurs (34,3 % après injection de glucose-l-C^* et 32,7 % après injection de glucose-6-C'*).…”

Section: B Metabolisme Oxydatif Du Rat Nephrotique In Totounclassified

“…Le régime peut influencer le type de substrat préférentiellement oxydé. En effet, Mayes et Felts (1967) avaient constaté que le rat normal nourri en hydrates de carbone oxydait moins de palmitate et plus de glucose-U-C^* que le rat normal à jeùn. Nos rats néphrotiques se comportent à ce point de vue seulement comme les rats nourris en hydrates de carbone.…”

Section: B Metabolisme Oxydatif Du Rat Nephrotique In Totounclassified

“…Le même fait avait été observé par Mayes et Felts (1967). La vitesse d'excrétion dépend essentiellement du pool de bicarbonate ; cette substance n'est guère utilisée dans le sens de la synthèse vers le palmitate et le glucose ; en effet, l'injection de bicarbonate marqué ne permet de retrouver qu'une faible fraction de la radioactivité dans le glucose (Wagle et Ashmore, 1963) et moins encore dans le palmitate .…”

Section: B Metabolisme Oxydatif Du Rat Nephrotique In Totounclassified

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Le Métabolisme Lipidique dans le Syndrome Néphrotique.

Malmendier¹,

Lambert²

1970

Ann Intern Med

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Thèse de doctorat/ PhD ThesisCitation APA: Malmendier, C. (1969 Cette thèse de doctorat a été numérisée par l'Université libre de Bruxelles. L'auteur qui s'opposerait à sa mise en ligne dans DI-fusion est invité à prendre contact avec l'Université (di-fusion@ulb.ac.be).Dans le cas où une version électronique native de la thèse existe, l'Université ne peut garantir que la présente version numérisée soit identique à la version électronique native, ni qu'elle soit la version officielle définitive de la thèse.DI-fusion, le Dépôt Institutionnel de l'Université libre de Bruxelles, recueille la production scientifique de l'Université, mise à disposition en libre accès autant que possible. Les oeuvres accessibles dans DI-fusion sont protégées par la législation belge relative aux droits d'auteur et aux droits voisins. Toute personne peut, sans avoir à demander l'autorisation de l'auteur ou de l'ayant-droit, à des fins d'usage privé ou à des fins d'illustration de l'enseignement ou de recherche scientifique, dans la mesure justifiée par le but non lucratif poursuivi, lire, télécharger ou reproduire sur papier ou sur tout autre support, les articles ou des fragments d'autres oeuvres, disponibles dans DI-fusion, pour autant que :Le nom des auteurs, le titre et la référence bibliographique complète soient cités; L'identifiant unique attribué aux métadonnées dans DI-fusion (permalink) soit indiqué;Le contenu ne soit pas modifié.

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Sympathetic Nervous System and Cardiovascular Alterations Due to Food Restrictions

Shah

Dhalla

2021

Cellular and Biochemical Mechanisms of Obesity

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Excessive food intake over a prolonged period is known to result in obesity, a risk factor for heart disease, associated with derangements of myocardial metabolism. Furthermore, food restriction has been shown to reduce obesity, attenuate metabolic changes in the myocardium and improve hemodynamic performance. This article is therefore intended to discuss the impact of food restriction on cardiovascular performance and sympathetic activity to understand the mechanisms for its beneficial effects. Feeding rats 25% of ad libitum diet (severe food restriction) increased blood pressure and left ventricular function during 2 to 7 days but decreased these parameters as well as heart rate during 10 to 14 days. Both plasma and cardiac norepinephrine levels were increased during 2 to 14 days whereas plasma epinephrine levels were elevated during 2 to 7 days and cardiac epinephrine content was increased during 10 to 14 days of feeding 25% of ad libitum diet. Restriction of food (25% ad libitum) for 14 days also attenuated the epinephrine-induced inotropic effect as well as different types of arrhythmias; this was associated with reduction of β-adrenoceptor density in the myocardium. An increase in sympathetic activity was also seen due to starvation of animals for 4 days. Feeding (50% ad libitum) diet (moderate food restriction) for 14 and 28 days showed depression in different parameters of cardiovascular function as well as increased cardiac norepinephrine and epinephrine content whereas plasma norepinephrine levels were increased at 14 days and decreased at 28 days without any changes in plasma epinephrine levels. These studies indicate that augmentation of sympathetic activity is associated with enhanced cardiovascular performance at initial stages followed by depression in

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Comparison of oxidative metabolism in starved, fat-fed and carbohydrate-fed rats

Cited by 22 publications

References 18 publications

Differences in energy expenditure and substrate oxidation between habitual high fat and low fat consumers (phenotypes)

Differences in energy expenditure and substrate oxidation between habitual high fat and low fat consumers (phenotypes)

Le Métabolisme Lipidique dans le Syndrome Néphrotique.

Sympathetic Nervous System and Cardiovascular Alterations Due to Food Restrictions

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