Comparison of ovarian cancer markers in endometriosis favours HE4 over CA125

McKinnon, Brett; Mueller, Michael D.; Nirgianakis, Konstantinos; Bersinger, Nick A.

doi:10.3892/mmr.2015.4062

Cited by 28 publications

(16 citation statements)

References 39 publications

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“…This can cause uncertainty and confusion among those with a negative test, potentially leading to unnecessary presumptive hormonal treatment. Alternative non‐invasive biomarkers currently being investigated include human epididymis protein 4 and miRNA, which provide potential for accurate biomarkers of the future. It is therefore unlikely that CA 125 will have a lasting role as a non‐invasive diagnostic tool for endometriosis.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic accuracy of cancer antigen 125 for endometriosis: a systematic review and meta‐analysis

Hirsch

Duffy

Davis

et al. 2016

BJOG

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Section: Discussionmentioning

confidence: 99%

Diagnostic accuracy of cancer antigen 125 for endometriosis: a systematic review and meta‐analysis

Hirsch

Duffy

Davis

et al. 2016

BJOG

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“…Laparoscopic visualization of lesions con rmed by histology 4 is the go-to-method for EMS diagnosis, and clinically de nitive diagnosis could take up to 11 years. Although CA125 and HE4 are widely used to monitor the occurrence of ovarian cancer, they are not speci c for the detection of EMS 5,6 . There is a clear need for noninvasive and sensitive methods for early and speci c diagnosis of EMS.…”

Section: Introductionmentioning

confidence: 99%

Exosomal miRNAs as novel potential biomarkers for endometriosis

Zhang

Líu

Zhu

et al. 2020

Preprint

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Background: Endometriosis (EMS) is a chronic gynaecological disease. Exosomal miRNAs appear to be associated with the progression of EMS, which suggest potential circulating biomarkers in EMS.Methods: Differential centrifugation, illumina small RNA sequencing, bioinformatics analysis and qRT-PCR are used to compare the pelvic fluid of patients with a clinical diagnosis of EMS and matched controls.Results: Six miRNAs (miR-135a-5p, miR-196a-5p, miR-449b-5p, miR-4454, miR-4286, and miR-5100) showed significant differences in the EMS group in initial screening (log2FC > 2). Receiver-operator curve (ROC) analysis further indicated miR-4454 (area under the curve (AUC) = 0.956, P < 0.05) and miR-5100(area under the curve (AUC) = 0.900, P < 0.05) were highly correlated with the pathogenesis of EMS. Validation on the samples from 10 patients and 10 healthy people.Conclusion: Our miRNA expression data provide altered expression and potential prospects for biomarkers in EMS.

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“…However, CA19-9 also elevates in patients with OVC 11 and chronic pancreatitis. 12 Similarly, human epididymis protein 4 (HE4), an approved serum biomarker for OVC, 13,14 is also overexpressed in patients with PC, 15,16 endometrial cancer, 17 and lung cancer. 18,19 MMP-7, [20][21][22] MUC-4 23,24 and mesothelin 25,26 are some other examples of potential biomarkers for PC have also been iden-tied as potential biomarkers for OVC.…”

Section: Introductionmentioning

confidence: 99%