Comparison of outcomes of transplantation and resection in patients with early hepatocellular carcinoma: a meta-analysis

Dhir, Mashaal; Lyden, Elizabeth; Smith, Lynette M.; Are, Chandrakanth

doi:10.1111/j.1477-2574.2012.00500.x

Cited by 76 publications

(68 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, there are four additional meta-analyses investigating the superiority of any of these two treatment options. In mutual agreement, all publications demonstrate superiority for liver transplantation for the treatment of HCC at the early BCLC stage A [136][137][138] or AJCC stage Ⅰ and Ⅱ HCC [139] . In contrast, liver resection has been demonstrated to yield similar outcome results compared to liver transplantation in patients with incomplete cirrhosis (Ishak score 0-4), thus for these patients, liver transplantation should be avoided in this subgroup of patients [139] .…”

Section: Transplantation Vs Liver Resectionmentioning

confidence: 90%

Hepatocellular carcinoma: Surgeon's view on latest findings and future perspectives

Slotta

Kollmar

Ellenrieder

et al. 2015

WJH

View full text Add to dashboard Cite

Hepatocellular carcinoma (HCC) is the most common liver-derived malignancy with a high fatality rate. Risk factors for the development of HCC have been identified and are clearly described. However, due to the lack of tumor-specific symptoms, HCC are diagnosed at progressed tumor stages in most patients, and thus curative therapeutic options are limited. The focus of this review is on surgical therapeutic options which can be offered to patients with HCC with special regard to recent findings, not exclusively focused on surgical therapy, but also to other treatment modalities. Further, potential promising future perspectives for the treatment of HCC are discussed. EPIDEMIOLOGYHepatocellular carcinoma (HCC) is a very common malignant disease with more than 700000 new patients diagnosed per year. Interestingly, the incidence of HCC varies relevantly throughout the world. Whereas HCC is a very common malignant disease in sub-Saharan Africa, and central and south-east Asia with incidence rates of 20-47/100000 habitants, the incidence of REVIEW Submit a

show abstract

Section: Transplantation Vs Liver Resectionmentioning

confidence: 90%

Hepatocellular carcinoma: Surgeon's view on latest findings and future perspectives

Slotta

Kollmar

Ellenrieder

et al. 2015

WJH

View full text Add to dashboard Cite

show abstract

“…Some studies showed the superiority of LT over LR for patients with Child A and early HCC [28], while others recommend resection due to some reasons such as scarcity of organs and high cost despite they admit that the best option is still LT for these patients [29]. A meta-analysis showed that in patients with early HCC, LT is associated with a significant survival advantage over LR [30]. Overall, based on literature and our outcomes of LT for HCC within the Milan criteria, we recommend LT for these patients.…”

Section: Discussionmentioning

confidence: 99%

Living Donor Liver Transplantation Outcomes for Hepatocellular Carcinoma Beyond Milan or UCSF Criteria

et al. 2014

View full text Add to dashboard Cite

Liver transplantation (LT) is the most effective treatment for hepatocellular carcinoma (HCC) that arises from cirrhosis. The Milan and the University of California, San Francisco (UCSF) selection criteria have resulted in major improvements in patient survival. We assessed our outcomes for patients with HCC that were beyond the Milan and UCSF criteria after living donor liver transplantation. We reviewed the data for 109 patients with cirrhosis and HCC who underwent living donor right lobe liver transplantation (living donor liver transplantation; LDLT) during the period from July 2004 to July 2012. Sixteen (14.7 %) patients had HCC recurrences during a mean follow-up of 35.4±26.2 months (range 4-100 months). The mean time to recurrence was 11±9.4 months (range 4-26 months). Survival rates were not significantly different between patients with HCC that met and were beyond the Milan and UCSF criteria (p=0.761 and p=0.861, respectively). The Milan and UCSF criteria were not independent risk factors for HCC recurrence or patient survival. Only poorly differentiated tumors were associated with a lower survival rate (OR=8.656, 95 % confidence interval (CI) 2.01-37.16; p= 0.004). Survival rates for patients with HCC that were beyond conventional selection criteria should encourage reconsidering the acceptable thresholds of these criteria so that more HCC patients may undergo LT without affecting outcomes.

show abstract

“…Pooling of data from studies which conducted intention-to-treat survival analysis demonstrated no significant difference in survival between the two treatment strategies at 5 years. Another meta-analysis on an intention-to-treat basis also found no significant difference between the outcomes of the two groups [59] . The other key finding highlighted by these two systematic reviews is the lack of prospective/randomised or even simply well-matched studies in the literature.…”

Section: Liver Resection Vs Liver Transplantationmentioning

confidence: 99%

Surgical management of hepatocellular carcinoma

Pang

Lam

2014

WJH

View full text Add to dashboard Cite

Hepatocellular carcinoma (HCC) is the second most common cause of death from cancer worldwide. Standard potentially curative treatments are either resection or transplantation. The aim of this paper is to provide an overview of the surgical management of HCC, as well as highlight current issues in hepatic resection and transplantation. In summary, due to the relationship between HCC and chronic liver disease, the management of HCC depends both on tumourrelated and hepatic function-related considerations. As such, HCC is currently managed largely through nonsurgical means as the criteria, in relation to the above considerations, for surgical management is still largely

show abstract

Comparison of outcomes of transplantation and resection in patients with early hepatocellular carcinoma: a meta-analysis

Abstract: The current study demonstrates a favourable outcome in patients with early HCC treated by either transplantation or resection. Although transplantation was noted to have a survival advantage in some settings, resection continues to be a viable treatment approach.

Cited by 76 publications

References 43 publications

Hepatocellular carcinoma: Surgeon's view on latest findings and future perspectives

Hepatocellular carcinoma: Surgeon's view on latest findings and future perspectives

Living Donor Liver Transplantation Outcomes for Hepatocellular Carcinoma Beyond Milan or UCSF Criteria

Surgical management of hepatocellular carcinoma

Contact Info

Product

Resources

About