Comparison of outcomes of prenatal versus postnatal presentation of posterior urethral valves: a systematic review and meta-analysis

Short-term postnatal renal outcome after vesico-amniotic shunting in boys with posterior urethral valves diagnosed prenatally

“…Poor outcome was associated with significantly higher nadir serum creatinine in the first year of life, bilateral vesicoureteric reflux and breakthrough UTIs. Interestingly, the long-term outcome did not differ among boys diagnosed pre-and postnatally [11,16]. This observation was also reported in the study by Vasconcelos et al Their survival analysis showed no differences in incidence of hypertension and proteinuria, CKD stage ≥ 3 and 5 and incidence of death [12].…”

“…In general, prenatal intervention is supposed to give a chance for normal development and possibly preservation of kidney function after birth. However, a recent meta-analysis showed that early prenatal detection and intervention did not have a significant influence on the final outcome with regard to CKD progression and dialysis or transplant use [11]. In this aspect, because prenatal interventions carry risks for both the mother and the fetus, in each case the decision must be made individually and with caution.…”

Congenital urinary obstruction and renal failure: has fetal ultrasound improved the prognosis?

“…The lengths of follow-up were not given. 17 Decompression of the bladder in utero with vesico-amniotic shunts has been used with varying degrees of success. A randomised trial was attempted, but had to be closed early because of poor recruitment.…”

“…However, a meta‐analysis of articles up to March 2022 showed no difference in chronic kidney disease outcomes between pre‐ and postnatal diagnosis. The lengths of follow‐up were not given 17 …”