“…There are no established guidelines for managing BRI, but a few retrospective studies have reported that 25% to 40% of eyes that received initial vitreous biopsy and intravitreal antibiotics ultimately required pars plana vitrectomy to eradicate the infection. 150,156,157 Bleb Leaks Bleb leaks can be encountered early (within 4 wk of surgery) or late (months to years) in the postoperative period. Reported rates of bleb leakage are 8% to 80% for early onset and 3% to 25% for delayed onset.…”