Comparison of outcomes for cancer patients discussed and not discussed at a multidisciplinary meeting

Rogers, Mark; Matheson, Leigh; Garrard, Brooke; Maher, Bianca; Cowdery, Stephanie; Luo, Wei; Reed, Malcolm; Riches, Sue; Pitson, Graham; Ashley, David M.

doi:10.1016/j.puhe.2017.04.022

Cited by 24 publications

(66 citation statements)

References 21 publications

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“…MDT procedures have led to changes in the management of breast cancer patients, but a consistent survival benefit has not been demonstrated and most centers do not track compliance with the MDT recommendations [ 5 , [7] , [8] , [9] , 14 ]. Thus, there is a clear need to document compliance with MDT decisions and perform comparative analyses to determine whether non-compliance with MDT recommendations is detrimental to prognosis.…”

Section: Discussionmentioning

confidence: 99%

“…Other reported benefits of MDT include providing consistent, continuous, and coordinated work for doctors, enhancing supportive care for patients, and improving access to clinical trials [ [5] , [6] , [7] ]. However, it remains controversial whether MDT itself and compliance with MDT recommendations improve the prognosis for early breast cancer patients [ [8] , [9] , [10] , [11] ]. Several factors may influence compliance with MDT recommendations among breast cancer patients.…”

Section: Introductionmentioning

confidence: 99%

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Compliance with multidisciplinary team recommendations and disease outcomes in early breast cancer patients: An analysis of 4501 consecutive patients

et al. 2020

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Background Multidisciplinary team (MDT) discussions are widely held to facilitate the diagnosis and treatment of breast cancer, but patient compliance with the MDT recommendations and the impact of compliance on disease outcome are uncertain. Methods We conducted a retrospective review of data from a prospective database of breast cancer patients treated at Shanghai Ruijin Hospital between April 2013 and August 2018. MDT discussions were held for all patients before they started adjuvant therapy. The patients were classified into compliant and non-compliant groups according to whether they received the MDT-recommended regimens. We also analyzed which clinicopathological factors were associated with compliance and prognosis. Results Of 4501 breast cancer patients, 3681 (81.8%) and 820 (18.2%) were included in the compliant and non-compliant groups, respectively. Age >70 years ( P < 0.001), invasive ductal carcinoma ( P < 0.001), and histological grade III ( P = 0.011) were independently associated with higher risk of non-compliance, whereas Ki-67 labeling index ≥14% and history of benign breast disease were independently associated with compliance. Disease-free survival (hazard ratio [HR] 1.813, 95% confidence interval [CI] 1.367–2.405, P < 0.001) and overall survival (HR 2.478, 95% CI 1.431–4.291, P < 0.001) were worse in the non-compliant group. Conclusions Several clinicopathological factors were associated with non-compliance with MDT recommendations for early breast cancer patients. Non-compliance was associated with worse disease outcome.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Compliance with multidisciplinary team recommendations and disease outcomes in early breast cancer patients: An analysis of 4501 consecutive patients

et al. 2020

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“…A recent study showed improved survival in patients with haematological and lung cancers that were assessed in multidisciplinary meetings. However, such benefits were not significant among patients with colorectal and breast cancers 28 …”

Section: Cost Effectivenessmentioning

confidence: 91%

Cardio‐oncology discipline: focus on the necessities in developing countries

et al. 2020

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Cardiovascular diseases constitute one of the main aetiologies of mortality among patients with cancer. Population ageing and cancer survival rate improvements have resulted in the coexistence of cardiovascular diseases and malignancies in an increasing number of patients. With the diversity in treatments and the introduction of new drug lines, multiple mechanisms of cardiovascular injury have been recognized in these patients. Cardio-oncology is an emerging entity introduced to provide a proper solution to the several challenges encountered in the management of patients with cancer and cardiac involvement. This review will assess the logical grounds for establishing a cardio-oncology unit, describe the main objectives and the detailed responsibilities in such systems, and outline the target population. Furthermore, the importance of research and appropriate data collection will be highlighted. Lastly, the special considerations and modifications required for setting up such centres in the developing countries are discussed.

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“…One-year survival was 15% higher in the MDT group (33% vs. 18%). Rogers et al from Australia analyzed all newly diagnosed cancer patients between 2009-2012, including 593 with lung cancer of whom 60% were presented at an MDT meeting within 60 days of diagnosis (10). They found that the MDT group had a significantly lower mortality after adjusting for age, stage, comorbidity and treatment: HR 0.62; 95% CI: 0.50-0.76.…”

Section: Editorialmentioning

confidence: 99%

The multidisciplinary lung cancer team meeting: increasing evidence that it should be considered a medical intervention in its own right

Dickhoff

Dahele

2019

J. Thorac. Dis.

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Comparison of outcomes for cancer patients discussed and not discussed at a multidisciplinary meeting

Cited by 24 publications

References 21 publications

Compliance with multidisciplinary team recommendations and disease outcomes in early breast cancer patients: An analysis of 4501 consecutive patients

Compliance with multidisciplinary team recommendations and disease outcomes in early breast cancer patients: An analysis of 4501 consecutive patients

Cardio‐oncology discipline: focus on the necessities in developing countries

The multidisciplinary lung cancer team meeting: increasing evidence that it should be considered a medical intervention in its own right

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