Comparison of outcomes between neuroendocrine thymic tumours and other subtypes of thymic carcinomas: a joint analysis of the European Society of Thoracic Surgeons and the International Thymic Malignancy Interest Group

Abstract

This represents the largest clinical series of TCs and NETTs collected. Despite the biological aggressiveness of these rare neoplasms, the 5-year survival rate after resection is over 60% and TCs and NETT showed a similar rate of survival and recurrences after surgery.

Evaluation of the prognostic value of surgery and postoperative radiotherapy for patients with thymic neuroendocrine tumors: A propensity‐matched study based on the SEER database

“…Similar to published reports, we found that TNETs were larger than thymomas and thymic carcinomas, but were not significantly different ( P = 0.15) . Moreover, compared to other thymic tumors, TNETs were more likely to present with lymph node metastasis.…”

“…Similar to published reports, we found that TNETs were larger than thymomas and thymic carcinomas, but were not significantly different (P = 0.15). 6,27 Moreover, compared to other thymic tumors, TNETs were more likely to present with lymph node metastasis. Weksler et al analyzed thymic carcinoma and TNET patients who underwent lymph node dissection and suggested that nodal metastases may be a negative prognostic factor in these patients.…”

“…In the present study, the survival of patients with TNETs was significantly shorter than that of patients with thymomas, whereas there was no difference between patients with TNETs and thymic carcinoma, consistent with previous reports. 27,28 Considering the difference in biological behavior, the latest WHO tumor classification also distinguished TNETs from thymoma. Thus, our results confirm that the malignancy features of TNETs are similar to those in thymic carcinoma but significantly different from those of thymoma.…”

Thymic large cell neuroendocrine carcinoma – a rare and aggressive tumor: a case report

“…Complete surgical resection with or without chemotherapy seems to have a better outcome [9, 17]. The therapeutic modalities used in thymic NET are often those of lung NET; however, specific treatment for thymic tumors needs to be clearly defined [5, 17].…”

Multimodality therapy for locally-advanced thymic epithelial tumors: where are we now?

“…The interest on surgical management of thymic neoplasms has never been so evident as in the last few years, following the publication of several multi-institutional large series, especially thanks to a formidable scientific effort by the European Society for Thoracic Surgeons (ESTS) and the International Thymic Malignancy Interest Group (ITMIG) (1)(2)(3)(4)(5)(6).…”