Comparison of outcome in patients with culture-negative versus culture-positive active infective endocarditis

Characteristics and Analysis of Risk Factors for Mortality in Infective Endocarditis

“…The determination of effective microorganism, definition of species level and assignment of antibiotic sensitivity are important for planning the optimal treatment [21]. Watanakunakorn et al [26] reported that the mortality was low in culture negative cases whereas it was just the opposite in Zamorano et al [27]. In our study, similar to the study by Tariq et al [28], no difference was found between the two groups in terms of mortality.…”

A Comparison of Culture-Positive and Culture-Negative Health-Care-Associated Pneumonia

“…Prior studies of septic shock, endocarditis, and CAP have suggested that there may be differences between culture-positive (CP) patients and culture-negative (CN) patients with these infections. [11][12][13][14][15][16] Therefore, we carried out a study with two goals. The fi rst goal of this study was to determine whether important demographic differences, including risk factors for HCAP, exist between CP and CN patients.…”

“…[11][12][13][14][15][16] Rello et al 12 evaluated 204 patients with severe CAP. A microbiologic diagnosis of pneumonia was established in 117 patients (57.4%) Hospital mortality was found to be higher among patients with an established microbiologic cause, but this difference was vasopressors, bacteremia, and escalation of antimicrobial therapy were consistently associated with hospital mortality for all cohorts examined.…”

Infective endocarditis: Absence of microbiological diagnosis is an independent predictor of inhospital mortality

“…It is defined as IE with three or more negative blood cultures (aerobic and anaerobic) in spite of prolonged incubation [2,3]. It accounts for 3-31% of all IE, [4,5] and might entail high morbidity and mortality [6,7,8] due to delayed diagnosis and difficulty to determine an adequate treatment [9]. When blood culture-negative IE is suspected, a battery of diagnostic tests should be performed in order to achieve a correct diagnosis [8].…”