Comparison of Outcome between Invasive Lobular Carcinoma (ILC) and Invasive Ductal Carcinoma (IDC) Patients Treating with Breast Conserving Surgery (BCS) and Radical Dose of Intraoperative Electron Radiotherapy (IOERT)

Salati, Azam; Akbari, Mohammad Esmaeil; Nafissi, Nahid; Noorian, Sajad; Mahdavi, Seyed Rabi; Moayeri, Hassan; Shormeij, Zeinab; Tutuni, Mahdieh; Saberi, Najmeh; Shahani, Minoo

doi:10.5812/ijcm.80985

Cited by 5 publications

(6 citation statements)

References 20 publications

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“…The evidence suggests that all women should be vigilant of any change in their bodies and consider undergoing validated diagnostic tests, annual specialized examinations, and screening programs. Besides, our findings are in line with previous reports that people with invasive lobular carcinoma (ILC) experience worse prognosis compared with those with invasive ductal carcinoma (IDC) 15 , 42 , and that ILC is less common but more difficult to diagnose with mammography, and is usually diagnosed at an end stage 43 . Regarding signs of BC, our results showed that discharge and pain were associated with end-stage diagnosis compared to those with a lump.…”

Section: Discussionsupporting

confidence: 92%

Determinants of delay in diagnosis and end stage at presentation among breast cancer patients in Iran: a multi-center study

Foroozani

Ghiasvand

Mohammadianpanah

et al. 2020

Sci Rep

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One of the reasons for high mortality of breast cancer (BC) is long delay in seeking medical care and end stage at presentation. This study was designed to measure the association between a wide range of socio-demographic and clinical factors with diagnostic delay in BC and stage at presentation among Iranian patients. From June 2017 to December 2019, 725 patients with newly diagnosed BC in Shiraz and Kermanshah were selected and information on BC diagnosis delay was obtained from the patient’s medical record. Data on socio-economic status was obtained via a structured interview. Our findings suggest that 45.8% of the patients were diagnosed at a late stage (stage 3 or higher). A total of 244 (34%) patients had more than 3 months delay in diagnosis. We found a significant association between stage at diagnosis and place of residence (adjusted odds ratio (aOR rural vs. urban = 1.69, 95% CI 1.49–1.97), marital status (aOR 1.61, 95% CI 1.42–1.88), family history of BC (aOR 1.46, 95% CI 1.01–2.13), and history of benign breast disease (BBD) (aOR 1.94, 95% CI 1.39–2.72) or unaware of breast self-examination (BSE) (aOR 1.42, 95% CI 1.42–1.85), delay time (aOR 3.25, 95% CI 1.04–5.21), and left breast tumor (aOR right vs. left 2.64, 95% CI 1.88–3.71) and smoking (aOR no vs. yes 1.59, 95% CI 1.36–1.97). Also, delay in diagnosis was associated with age, family income, health insurance, place of residence, marital status, menopausal status, history of BBD, awareness of breast self-examination, type of first symptoms, tumor histology type, BMI and comorbidity (p < 0.05 for all). Factors including history of BBD, awareness of BSE, and suffering from chronic diseases were factors associated with both delay in diagnosis and end stage of disease. These mainly modifiable factors are associated with the progression of the disease.

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Section: Discussionsupporting

confidence: 92%

Determinants of delay in diagnosis and end stage at presentation among breast cancer patients in Iran: a multi-center study

Foroozani

Ghiasvand

Mohammadianpanah

et al. 2020

Sci Rep

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“…It is broadly affirmed that cell proliferation is different when cultured in a two-dimensional (2D) cell culture system than in 3D conditions 23 . In addition, recent data linked with mathematical models also explained how the stiffness of the substrate could control the growth of cancer cells 24 , 25 . Tissue stiffness is a crucial factor of the ECM that contributing to epithelial-mesenchymal transition (EMT).…”

Section: Introductionmentioning

confidence: 99%

Radiobiological effects of wound fluid on breast cancer cell lines and human-derived tumor spheroids in 2D and microfluidic culture

Jeibouei

Hojat

Mostafavi

et al. 2022

Sci Rep

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Intraoperative radiotherapy (IORT) could abrogate cancer recurrences, but the underlying mechanisms are unclear. To clarify the effects of IORT-induced wound fluid on tumor progression, we treated breast cancer cell lines and human-derived tumor spheroids in 2D and microfluidic cell culture systems, respectively. The viability, migration, and invasion of the cells under treatment of IORT-induced wound fluid (WF-RT) and the cells under surgery-induced wound fluid (WF) were compared. Our findings showed that cell viability was increased in spheroids under both WF treatments, whereas viability of the cell lines depended on the type of cells and incubation times. Both WFs significantly increased sub-G1 and arrested the cells in G0/G1 phases associated with increased P16 and P21 expression levels. The expression level of Caspase 3 in both cell culture systems and for both WF-treated groups was significantly increased. Furthermore, our results revealed that although the migration was increased in both systems of WF-treated cells compared to cell culture media-treated cells, E-cadherin expression was significantly increased only in the WF-RT group. In conclusion, WF-RT could not effectively inhibit tumor progression in an ex vivo tumor-on-chip model. Moreover, our data suggest that a microfluidic system could be a suitable 3D system to mimic in vivo tumor conditions than 2D cell culture.

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“…In another research, the omission of boost dose increased the recurrence rate from 3.6% to 4.5% compared with cases who received a boost dose [36]. e reduction of mortality in breast cancer patients, who received IORT as boost or radical dose is another valuable effect of RT in breast cancer patients due to the induced immunological effect of local therapy that reduces cancerrelated death [37][38][39].…”

Section: Discussionmentioning

confidence: 99%

Saving the Breast Saves the Lives of Breast Cancer Patients

Akbari

Khayamzadeh

Moradi

et al. 2020

International Journal of Surgical Oncology

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Introduction. Surgery has been known as the procedure of choice for breast cancer management since 1700 years before Christ. Nowadays, breast-conserving surgery and mastectomy are performed in selected cases with specific clinical criteria. Here, we compare these two procedures for breast cancer patients with variable features in Cancer Research Center, Tehran, as a single institution experience. Methods. In this 25-year follow-up retrospective cohort study, we identified breast cancer patients who had undergone breast-conserving therapy or mastectomy. Disease-free survival and overall survival were evaluated using Kaplan–Meier survival analysis and the log-rank test between the two groups. A p value less than 0.05 was considered statistically significant. Results. A total of 3358 breast cancer patients, including 61% breast-conserving therapy and 39% mastectomy cases were identified, with a mean follow-up time of 94 months. The overall survival and disease-free survival of all cases were significantly better in breast-conserved patients, particularly in early-stage breast cancer with favorable clinical, pathological, and biological features. Ten-year disease-free survival and overall survival in breast-conserving therapy and mastectomy cases were 74%, 88% and 58%, 80%, respectively. Conclusion. Breast-conserving surgery and radiation therapy prove to be an appropriate treatment option for breast cancer patients in terms of overall survival and disease-free survival when indicated.

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Comparison of Outcome between Invasive Lobular Carcinoma (ILC) and Invasive Ductal Carcinoma (IDC) Patients Treating with Breast Conserving Surgery (BCS) and Radical Dose of Intraoperative Electron Radiotherapy (IOERT)

Cited by 5 publications

References 20 publications

Determinants of delay in diagnosis and end stage at presentation among breast cancer patients in Iran: a multi-center study

Determinants of delay in diagnosis and end stage at presentation among breast cancer patients in Iran: a multi-center study

Radiobiological effects of wound fluid on breast cancer cell lines and human-derived tumor spheroids in 2D and microfluidic culture

Saving the Breast Saves the Lives of Breast Cancer Patients

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