Comparison of Ostene® and Bone wax on Bone Healing: A Comparative experimental study in rabbits.

Abstract

Introduction: Ostene® is a new synthetic bone hemostatic waxlike inert and biocompatible material that dissolves within two days after application. Bone wax is a well-known topical hemostatic agent, easy to use, and its application is very simple. Wound healing is a complex biological process; Bone is a dynamic tissue that is continuously resorbed, renewed, and remodeled. Materials and methods: Twenty domestic rabbits were divided into four groups (day 1, day 3, day 7, and day 14). Each rabbit was anaesthetized and three holes were drilled in the mandible: one was filled with Ostene®, another with bone wax, and the other was left unfilled as control. Sites of intervention were assessed by histopathology. Results and Discussion: Ostene® and bone wax showed osteoinductive property in bone healing with no inflammatory reaction. Our study revealed new bone formation within 14 days in Ostene® group. After histopathological analysis and scoring was finished, analysis by SPSS 14 software showed a significant difference between the use of Ostene® and bone wax. Conclusion: Ostene® showed superiority over bone wax in bone healing, and it can be used in the same way as bone wax with no interference with bone healing and osteogenesis. Ostene® has no side effects following application.

Novel resorbable bone wax containing β-TCP and starch microspheres for accelerating bone hemostasis and promoting regeneration

“…To avoid the problems associated with traditional bone wax, new resorbable synthetic substitutes have been developed, including PEG/microfibrillar collagen composites ( Orgill et al, 2015 ), alkylene oxide copolymers ( Salim, 2018 ; Kim et al, 2020 ; Choi et al, 2021 ), hydroxyapatite/polylactic acid ( Tham et al, 2018 ), alkylene oxide copolymers/carboxymethylcellulose sodium salt composites, poly (ethylene glycol)-poly (propylene glycol) copolymer/starch composites ( Suwanprateeb et al, 2014 ), modified calcium sulfate cement ( Zhou et al, 2018 ), and chitosan ( Chen et al, 2015 ). However, absorbable materials might cause allergic reactions and retardation of bone regeneration ( Schonauer et al, 2004 ).…”