Comparison of Orally Administered Cannabis Extract and Delta-9-Tetrahydrocannabinol in Treating Patients With Cancer-Related Anorexia-Cachexia Syndrome: A Multicenter, Phase III, Randomized, Double-Blind, Placebo-Controlled Clinical Trial From the Cannabis-In-Cachexia-Study-Group

Strasser, Florian; Lüftner, Diana; Possinger, K.; Ernst, Gernot; Ruhstaller, Thomas; Meißner, Winfried; Ko, You-Dschun; Schnelle, Martin; Reif, Marcus; Cerny, Thomas

doi:10.1200/jco.2005.05.1847

Cited by 347 publications

(277 citation statements)

References 38 publications

Supporting

Mentioning

261

Contrasting

Unclassified

Order By: Relevance

“…Although a number of nutritional supplements and drugs, such as Cannabis (Strasser et al 2006), eicosapentaenoic acid (Beck et al 1991, Barber et al 1999) and branched-chain amino acids have shown promising results in pre-clinical studies, the results of phase III clinical trials have failed to demonstrate a substantial effect of these drugs and nutritional supplements as treatments for cancer cachexia.…”

Section: Initial Effortsmentioning

confidence: 99%

Molecular and neuroendocrine mechanisms of cancer cachexia

Mendes

Pimentel

Costa

et al. 2015

Journal of Endocrinology

View full text Add to dashboard Cite

Cancer and its morbidities, such as cancer cachexia, constitute a major public health problem. Although cancer cachexia has afflicted humanity for centuries, its underlying multifactorial and complex physiopathology has hindered the understanding of its mechanism. During the last few decades we have witnessed a dramatic increase in the understanding of cancer cachexia pathophysiology. Anorexia and muscle and adipose tissue wasting are the main features of cancer cachexia. These apparently independent symptoms have humoral factors secreted by the tumor as a common cause. Importantly, the hypothalamus has emerged as an organ that senses the peripheral signals emanating from the tumoral environment, and not only elicits anorexia but also contributes to the development of muscle and adipose tissue loss. Herein, we review the roles of factors secreted by the tumor and its effects on the hypothalamus, muscle and adipose tissue, as well as highlighting the key targets that are being exploited for cancer cachexia treatment.

show abstract

Section: Initial Effortsmentioning

confidence: 99%

Molecular and neuroendocrine mechanisms of cancer cachexia

Mendes

Pimentel

Costa

et al. 2015

Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…A primary end point was appetite change during the study period from baseline with a VAS (0 mm = no anorexia, 100 mm = maximal anorexia). 47 …”

Section: Outcome Measures Of Appetitementioning

confidence: 99%

A Phase II Study of an Herbal Decoction That Includes Astragali Radix for Cancer-Associated Anorexia in Patients With Advanced Cancer

Lee

2010

Integr Cancer Ther

View full text Add to dashboard Cite

Hypothesis: Anorexia and cancer cachexia produce significant loss of adipose tissue and muscle mass and eventually reduce survival in cancer patients. Study design: This phase II study was conducted to assess the efficacy and the safety of an herbal decoction with Astragali Radix in patients with anorexia in advanced cancer. Methods: All patients with histologic evidence of an incurable malignancy had a weight loss of at least 5% during the preceding 6 months and a patient-estimated severe anorexia. The herbal decoction was administered 30 minutes after meals, three times a day for 3 weeks. The score of appetite, body weight, the cytokines, IL-1b, IL-6, TNF-a, and anthropometric measurements were assessed. For the assessment of anorexia, a visual analog scale (VAS: 0 mm = no anorexia, 100 mm = maximal anorexia) was used. Results: Eleven patients were recruited from January, 2007 to January, 2009. The mean age was 59.8 years old. The change in anorexia from baseline with the herbal decoction was significantly different and anorexia was improved (anorexia VAS score, 60mm vs. 40mm, p = 0.008). The mean value of the maximal body weight was 55.6 kg and differed significantly from the 54.6 kg at baseline (p = 0.009). Changes in cytokine levels and anthropometric measurements from baseline to the 3rd week were not significant. All toxicities were manageable. Conclusion: Appetite and body weight were improved with the herbal decoction. This herbal decoction shows some potential for management of cancer-related anorexia.

show abstract

“…Compounds, such as the lectins from mistletoe (Viscum album) or a proprietary Japanese polysaccharide extract from shitake (Lentinus edodes) are usually delivered intravenously or parenterally, and therefore are not dietary supplements according to regulatory standards in the United States. Whole cannabis, extracts, and to a lesser degree isolated compounds from cannabis, have been noted to ameliorate a variety of symptoms in cancer patients, including pain, nausea, anorexia, and cachexia [80]. However useful many clinicians find the herbal form of this medicine, the legal ambiguity and challenges with standardization of dosage make use of this substance beyond the scope of this review.…”

Section: Potential Benefits Of Dietary Supplementsmentioning

confidence: 99%