Comparison of oral squamous cell carcinoma in younger and older patients in India

Kuriakose, Moni Abraham; Sankaranarayanan, Meena; Nair, M. K. C.; Cherian, Thomas; Sugar, A.; Scully, Crispian; Prime, Steven L.

doi:10.1016/0964-1955(92)90038-3

Cited by 99 publications

(79 citation statements)

References 23 publications

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“…These conditions have been suggested as predisposing factors for OSCC (15). The most common clinical presentation of OSCC in our patients was exophytic lesion, but in the study of kuriakose et al and Manuel et al ulceroproliferative lesions were more common (6,14). This may be related to different habits of different cultures.…”

Section: Discussioncontrasting

confidence: 48%

“…Several studies showed that between 1 to 6 percent of oral cancers have been presented in patients under the age of 40 (1)(2)(3). Although there has been a declining trend in the overall incidence of OSCC, the incidence in young adults seems to be increasing worldwide (2,3,(4)(5)(6). It seems that biological behavior and etiology of OSCC in young patients are unlike older age groups and some studies suggest that oral cancer in young patients is more aggressive (6).…”

Section: Introductionmentioning

confidence: 99%

“…Although there has been a declining trend in the overall incidence of OSCC, the incidence in young adults seems to be increasing worldwide (2,3,(4)(5)(6). It seems that biological behavior and etiology of OSCC in young patients are unlike older age groups and some studies suggest that oral cancer in young patients is more aggressive (6). Recent studies revealed that there is no difference between clinical course and survival rate (2,(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

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Clinical and histopathological analysis of oral Squamous cell carcinoma of young patients in Mashhad, Iran: A retrospective study and review of literature

Falaki¹,

Dalirsani²,

Pakfetrat³

et al. 2011

Med Oral

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Objectives: Oral Squamous cell carcinoma (OSCC) is primarily a disease that mainly occurs in males in their sixth and seventh decades of life and is rare in young adults. Study Design: In this retrospective study, records of patients under the age of 40, with the diagnosis of OSCC in the Oral Medicine Department of Mashhad Dental Faculty during the past 13 years were analyzed. Their socioeconomic data, demographic, clinical and histopathological characteristics, risk factors, familial history were assessed and applicable studies and case reports in the literatures were reviewed. PCR (Polymerase chain reaction) analysis was also done for detection of human papilloma virus (HPV). Results: From 158 cases of OSCC diagnosed in our centre, 21 patients were younger than 40 years. Most of them were young men (12 cases). There was no significant risk factor in this group. The most common site of involvement was the tongue. The most common clinical presentation was exophytic lesion with ulcer. No HPV DNA was detected in these patients. Conclusion: Characteristics of OSCC in young patients are different from older age group. Major risk factors (smoking and alcohol consumption and HPV) were not etiologic factors for OSCC in young patients in our province.

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Section: Discussioncontrasting

confidence: 48%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical and histopathological analysis of oral Squamous cell carcinoma of young patients in Mashhad, Iran: A retrospective study and review of literature

Falaki¹,

Dalirsani²,

Pakfetrat³

et al. 2011

Med Oral

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“…The disease is an important cause of morbidity and mortality with a 5-year survival of less than 50% (1,2). Unlike other subsites of oral cavity like gingivo-buccal, tumors originating in the anterior part of tongue or oral tongue have an increased association with younger patients (3,4), spread early to lymph nodes (3), and have a higher regional failure (5). Tobacco and alcohol are common risk factors for this group of cancer.…”

Section: Introductionmentioning

confidence: 99%

A Minimal DNA Methylation Signature in Oral Tongue Squamous Cell Carcinoma Links Altered Methylation with Tumor Attributes

Krishnan

Dhas

Nair

et al. 2016

Molecular Cancer Research

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Oral tongue squamous cell carcinomas (OTSCC) are a homogenous group of aggressive tumors in the head and neck region that spread early to lymph nodes and have a higher incidence of regional failure. In addition, there is a rising incidence of oral tongue cancer in younger populations. Studies on functional DNA methylation changes linked with altered gene expression are critical for understanding the mechanisms underlying tumor development and metastasis. Such studies also provide important insight into biomarkers linked with viral infection, tumor metastasis, and patient survival in OTSCC. Therefore, we performed genome-wide methylation analysis of tumors (N ¼ 52) and correlated altered methylation with differential gene expression. The minimal tumor-specific DNA 5-methylcytosine signature identified genes near 16 different differentially methylated regions, which were validated using genomic data from The Cancer Genome Atlas cohort. In our cohort, hypermethylation of MIR10B was significantly associated with the differential expression of its target genes NR4A3 and BCL2L11 (P ¼ 0.0125 and P ¼ 0.014, respectively), which was inversely correlated with disease-free survival (P ¼ 9EÀ15 and P ¼ 2EÀ15, respectively) in patients. Finally, differential methylation in FUT3, TRIM5, TSPAN7, MAP3K8, RPS6KA2, SLC9A9, and NPAS3 genes was found to be predictive of certain clinical and epidemiologic parameters.Implications: This study reveals a functional minimal methylation profile in oral tongue tumors with associated risk habits, clinical, and epidemiologic outcomes. In addition, NR4A3 downregulation and correlation with patient survival suggests a potential target for therapeutic intervention in oral tongue tumors. Data from the current study are deposited in the NCBI Geo database (accession number GSE75540).

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“…[4][5][6] In contrast to the conventional patient with oral cancer, a significant proportion of these young patients seem to have an absence of traditional risk factors. 7,8 It has been suggested that oral cancer in the young may be a disease distinct from that occurring in older patients, with possibly a different etiology and disease progression. 9 Potential factors accounting for this increase in incidence of oral SCC in this age group are diverse and could reflect changes in dental care, diet, food processing, nutritional supplementation, sexual habits, and their subsequent effect on biologic processes.…”

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confidence: 99%

Distinct array comparative genomic hybridization profiles in oral squamous cell carcinoma occurring in young patients

et al. 2006

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Background. Oral cancer typically affects smokers older than 50 years of age. Recently, however, a marked increase in the number of patients 40 years old and younger, many with no history of tobacco smoking, has been noted. Studies in this age group have so far been restricted to genomic areas well recognized as abnormal in typical patients with oral cancer. The aim of this study was to assess genomic aberrations in oral cancer, using comparative genomic hybridization (CGH) microarray technology, and to compare the genomic aberration profile of patients older than 40 years old with those 40 years old and younger.Methods. Tumor samples from 20 patients with oral cancer (age range, 21-78; 10 smokers and 10 nonsmokers) were laser microdissected, and array CGH was used to identify genomic imbalances in these two cohorts.Results. The older cohort showed high numbers of gains and losses in contrast to very few copy number changes in the younger nonsmoker cohort. In concurrence with the literature, tumors from the older cohort manifested deletions involving 3p and 9p21 and gains involving 3q, 5q, 7p, 8q, 11q, and 20q. The younger group, particularly the nonsmokers, showed very few changes overall, and the aberrations were not in the sites classically associated with oral cancer. Deletion of CDKN2A (p16) was completely absent in the younger group but was present in 50% of the older cohort.Conclusions. We have demonstrated that there is far less genomic instability in young nonsmokers with oral cancer than found in typical patients with oral cancer. These observations indicate that oral cancer presenting at a younger age, particularly in nonsmokers, has a genomic profile different from the classically described oral cancer.

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Comparison of oral squamous cell carcinoma in younger and older patients in India

Cited by 99 publications

References 23 publications

Clinical and histopathological analysis of oral Squamous cell carcinoma of young patients in Mashhad, Iran: A retrospective study and review of literature

Clinical and histopathological analysis of oral Squamous cell carcinoma of young patients in Mashhad, Iran: A retrospective study and review of literature

A Minimal DNA Methylation Signature in Oral Tongue Squamous Cell Carcinoma Links Altered Methylation with Tumor Attributes

Distinct array comparative genomic hybridization profiles in oral squamous cell carcinoma occurring in young patients

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