Comparison of Oral Sirolimus, Prednisolone, and Combination of Both in Experimentally Induced Peritoneal Adhesion

Kazemi, Kourosh; Hosseinzadeh, Ahmad; Shahriarirad, Reza; Nikeghbalian, Saman; Kamran, Hooman; Hosseinpour, Parisa; Tanideh, Nader; Jamshidi, Kamran

doi:10.1016/j.jss.2022.02.047

Cited by 6 publications

(7 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Captopril demonstrated macroscopical and microscopically improved the attenuation of fibrosis formation in joints. This mechanism is mainly through decreasing the production of IL1, TNF, MMP, TGF, FGF, and VEGF [7, 18, 26, 36]. Several studies revealed the potent effect of captopril as an anti‐fibrotic agent.…”

Section: Discussionmentioning

confidence: 99%

“…A visual scoring system ranged from zero to three [19], including Score Zero: No Adhesions, Score One: Weak, mild, filmy adhesions that can be eliminated by minimal manual traction, Score Two: Moderate adhesion that can be eliminated by manual traction, Score Three: Dense fibrous adhesions that must be surgically removed. This scoring method was initially described by Rothkopf et al [29] and has been used in various animal studies [4, 9, 11, 18, 24, 41].…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Promising results of captopril in improving knee arthrofibrosis and cartilage status: an animal model study

et al. 2022

Self Cite

View full text Add to dashboard Cite

Purpose Several cytokines and growth factors start and progress the destruction process of joint hyaline cartilage and fibrosis formation. Captopril is classified as an Angiotensin-converting enzyme inhibitor in which several studies revealed that captopril significantly decreases fibrosis formation in some organs like the liver, heart, and kidney. This study aimed to evaluate the use of captopril in reducing the possibility of arthrofibrosis and osteoarthritis in an animal model. Method In this in-vivo animal model study, the anterior cruciate ligament of 24 rabbits was transected to induce osteoarthritis and arthrofibrosis. The control group contained 11 rabbits and the second group consisted of 13 rabbits. The second group was treated with 10 mg/ kilogram/day captopril through a nasogastric tube. The control group was treated with normal saline in the same way. Cartilage damage and osteoarthritis were evaluated by Osteoarthritis Research Society International (OARSI) scoring system. After 30 days, animals were sacrificed, and arthrofibrosis and cartilage damage were evaluated microscopically and macroscopically. Results According to macroscopic and microscopic evaluation, captopril dramatically reduced arthrofibrosis formation based on visual scoring and the Masson trichrome staining system. Cartilage damage was lower in the intervention group compared to the control group. Conclusions Captopril is an angiotensin-converting enzyme inhibitor that demonstrated to significantly decreases the possibility of arthrofibrosis. Although the beneficial preventive effect of captopril on osteoarthritis was not proved statistically, better results may be obtained if the route of administration or drug dosage is changed.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Promising results of captopril in improving knee arthrofibrosis and cartilage status: an animal model study

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…In group B, a combination of methylprednisolone and diphenhydramine (MP + DPH) solution (Iranhormone factory, Iran) with a concentration of 20 mg/kg was administered; Group C received colchicine (Modacine, Modava, Iran) dissolved in distilled water at a concentration of 0.02 mg/kg/day was administered; and in group D 1 mg/ kg oral prednisolone (as 5 mg tablets made by Iranhormone factory, Iran) daily in the morning using long metal gavage for an experimental period of two weeks plus a single dose of the medications two hours preoperatively. The dosage of medications was based on that of human subjects and also similar to previous studies [ 15 , 24 , 29 – 31 ].…”

Section: Methodsmentioning

confidence: 96%

“…We have previously demonstrated the effectiveness of macrolides (sirolimus) and prednisolone in preventing intra-abdominal adhesion formations [ 24 ]. Based on our hypothesis and evidence available in the literature, we designed this study to evaluate and compare the effects of DPH and methylprednisolone (MP), and also colchicine in the prevention of abdominal adhesion.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the preventive effect of colchicine versus diphenhydramine, prednisolone, and a combination therapy on intraperitoneal adhesion bands: an experimental study in rats

et al. 2023

Self Cite

View full text Add to dashboard Cite

Background Peritoneal adhesion formation is an inevitable consequence of abnormal repair of the peritoneum following different peritoneal injuries of intra-abdominal operations with the subsequent morbidity that they represent. Vast efforts have been made to elucidate the cause and prevent the development of abdominal adhesions. The aim of our study is to compare the capability of colchicine versus diphenhydramine (DPH) and methylprednisolone (MP), and also prednisolone in adhesion prevention. Methods Sixty-one male Wistar stock rats were divided into four groups. The first group attended as the control group. Groups 2, 3, and 4 received oral combination of MP + DPH solution (20 mg/kg), colchicine (0.02 mg/kg), and prednisolone (1 mg/ kg), respectively. Adhesion bands were induced by standardized abrasion of the peritoneum through a midline laparotomy. All rats were sacrificed on the 15th-day post medication administration and the subjects underwent an exploratory laparotomy. The presence of adhesions was evaluated with the modified using Nair's classification. Results The proportion of the control group with substantial adhesion bands (73.3%) was significantly higher than that of the MP + DPH (13.3%), colchicine (33.3%), and prednisolone (31.3%) groups. There were significant differences between the scores of the control and the MP + DPH, colchicine, and prednisolone groups (P = 0.001, 0.028, and 0.019, respectively). There was no statistically significant difference to favor colchicine against MP + DPH (P = 0.390) or MP + DPH against prednisolone (P = 0.394). Conclusions Both colchicine and combination of DPH + MP prevented postoperative abdominal adhesions separately in our study. However, the lowest adhesion formation rate was observed in the DPH + MP group, even lower than the prednisolone group.

show abstract

“…The current research was conducted at the Center of Comparative and Experimental Medicine, Shiraz University of Medical Sciences, Shiraz, Iran, and the study’s protocol followed the principles of the guideline of the Ministry of Health and Education of Medicine of Iran for care and use of laboratory animals, with ethical approval from the Institutional Animal Care and Use Committee of Research Center of Shiraz University of Medical Sciences (Ethical code: IR.SUMS.MED.REC.1395.S221). The sample size was assigned based on similar previous reports, and the minimum number of subjects needed, along with taking into account the risk of drop-out/mortality 19 – 23 . All attempts to minimize animal distress and to employ only the number of animals essential to attain reliable results were made.…”

Section: Methodsmentioning

confidence: 99%

Comparison of the effect of Everolimus, Prednisolone, and a combination of both on experimentally induced peritoneal adhesions in rats

Kazemi,

Jamshidi,

Naseri

et al. 2024

Sci Rep

Self Cite

View full text Add to dashboard Cite

Postoperative intra-abdominal adhesions represent a significant post-surgical problem. Its complications can cause a considerable clinical and cost burden. Herein, our study aimed to investigate the effect of Everolimus on peritoneal adhesion formation after inducing adhesions in rats. In this experimental study, adhesion bands were induced by intraperitoneal injection of 3 ml of 10% sterile talc solution in 64 male albino rats. The first group served as the control group. The second one received oral Prednisolone (1 mg/kg/day), the third received Everolimus (0.1 mg/kg/day), and group four received both drugs with similar dosages for four consecutive weeks. The formation of adhesion bands was qualitatively graded according to the Nair classification. The rats in the control group had extensive adhesions between the abdominal wall and the organs. Regarding substantial adhesion formation, 50% (8/16) of animals in the control group had substantial adhesions, while this rate in the groups receiving Prednisolone, Everolimus, and combination treatment was 31%, 31%, and 31%, respectively. Also, 68.75% (5/11) of the Prednisolone recipients had insubstantial adhesions, the same as Everolimus recipients, while in the combination group, 66.66% (10/15) rats had insubstantial adhesions. Everolimus demonstrated satisfactory results in reducing the rates of induced peritoneal adhesion in an experimental model, similar to Prednisolone and superior to a combination regime.

show abstract

Comparison of Oral Sirolimus, Prednisolone, and Combination of Both in Experimentally Induced Peritoneal Adhesion

Cited by 6 publications

References 18 publications

Promising results of captopril in improving knee arthrofibrosis and cartilage status: an animal model study

Promising results of captopril in improving knee arthrofibrosis and cartilage status: an animal model study

Comparison of the preventive effect of colchicine versus diphenhydramine, prednisolone, and a combination therapy on intraperitoneal adhesion bands: an experimental study in rats

Comparison of the effect of Everolimus, Prednisolone, and a combination of both on experimentally induced peritoneal adhesions in rats

Contact Info

Product

Resources

About