Comparison of oral midazolam with intranasal dexmedetomidine premedication for children undergoing CT imaging: a randomized, double‐blind, and controlled study

Abstract

In the doses and time intervals used in our study, intranasal dexmedetomidine (2.5 μg·kg ) was found to be superior to oral midazolam (0.5 mg·kg ) for producing satisfactory sedation for CT imaging.

Analysis of 17 948 pediatric patients undergoing procedural sedation with a combination of intranasal dexmedetomidine and ketamine

“…Numerous published studies found no adverse respiratory events associated with the use of intranasal dexmedetomidine and/or ketamine . Rate of respiratory events observed in this study is similar.…”

“…Dexmedetomidine is useful as a sedative/hypnotic, and offers the advantage of having both sedative and anxiolytic effects, as well as relatively mild analgesic properties and a relatively short elimination half‐life of 2 h . Dexmedetomidine has been useful by the intranasal route, but has some drawbacks in terms of effectiveness, onset and offset time.…”

“…and a relatively short elimination half-life of 2 h. 5 Dexmedetomidine has been useful by the intranasal route, [6][7][8][9][10] but has some drawbacks in terms of effectiveness, onset and offset time.…”

Median effective dose of intranasal dexmedetomidine sedation for transthoracic echocardiography in pediatric patients with noncyanotic congenital heart disease: An up‐and‐down sequential allocation trial

“…The significant clinical advantages of dexmedetomidine due to its sedative properties paralleling natural sleep, with minimal respiratory depression . Compared to traditional sedative such as midazolam, chloral hydrate, and propofol, patients treated with dexmedetomidine have fewer side effects and better arousability. When used as premedication by a noninvasive way, intranasal dexmedetomidine has been shown to confer an advantage over both buccal dexmedetomidine (1 μg kg −1 ) and oral midazolam (0.5 mg kg −1 ) …”

Intranasal deksmedetomidin er gunstig som premedikasjon til barn – sett fra anestesisykepleieres perspektiv

“…Deksmedetomidin har analgetikum-og anestetikumsparende effekt, påvirker i minimal grad respirasjonen og kan administreres via ulike ruter (1)(2)(3). Intranasal rute er lite traumatisk, og deksmedetomidin er smakløst, luktfritt og smertefritt ved bruk i neseslimhinnen, noe som gjør at medikamentet tolereres godt av barn (4,5).…”