Comparison of oral enprofylline and theophylline in asthmatic patients

Lc, Laursen; Johannesson, N.; Søndergaard, Ib; Weeke, B.

doi:10.1007/bf00541929

Cited by 17 publications

(9 citation statements)

References 10 publications

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“…The similarities in effects on lung function produced by enprofylline and theophylline agree well with the previous observations (Laursen et al, 1984) and give further support to the hypothesis that the antiasthmatic properties of xanthines are unrelated to their abilities to antagonise adenosine at receptor levels . The underlying mechanism is unknown and should be addressed in future studies.…”

Section: Discussionsupporting

confidence: 88%

Maximally effective plasma concentrations of enprofylline and theophylline during constant infusion.

Laursen¹,

Johannesson²,

Søndergaard³

et al. 1984

Brit J Clinical Pharma

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1 Bronchodilating effects produced by increasing intravenously administered doses of enprofylline and theophylline compared to placebo were evaluated in 20 asthmatic outpatients. 2 Three mean plasma plateaux of enprofylline of 1.5, 2.9 and 4.0 ,ug/ml produced a mean increase in forced expiratory volume in the first second (FEV1.0) as a percentage of baseline, of 12.8%, 18.8% and 30.1%, respectively.3 Comparable plasma plateaux of theophylline i.e. 5.5, 10.8 and 15.2 jig/ml produced a mean increase of FEV1.0 in percent of basal values of 12.4%, 21.6% and 28.2%, respectively. 4 Enprofylline at plasma concentrations above 2.9 ,ug/ml induced more headache and slightly more nausea than theophylline and placebo. Theophylline infusion produced more tremor (finger oscillation) than enprofylline and placebo. 5 Intravenously administered enprofylline produces bronchodilation comparable to theophylline in a mean dose ratio of 3.8.

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Section: Discussionsupporting

confidence: 88%

Maximally effective plasma concentrations of enprofylline and theophylline during constant infusion.

Laursen¹,

Johannesson²,

Søndergaard³

et al. 1984

Brit J Clinical Pharma

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“…Headaches and nausea are the most pronounced side-effects of enprofylline after single-dose administration when rap idly dissolving tablets or intravenous en profylline is administered [1,2] and after short-term treatment [10]. Headaches were also reported by most of the patients tak ing enprofylline in the present study.…”

Section: Discussionsupporting

confidence: 60%

“…Enprofylline (3-propyl-xanthine) is about 3-5 times as potent in its antiasth matic effects as theophylline when given as a single dose [1][2][3]. It is also free of some extrapulmonary effects produced by theo phylline such as CNS-stimuiant behav ioral effects, e.g.…”

Section: Introductionmentioning

confidence: 99%

“…convulsions and seizures, diuretic actions and gastrointestinal irri tant effects [4][5][6]. After the administration of single doses, enprofylline may induce dose-related transient headaches and nau sea [1,2,7], Because of the short half-life of enprofylline (about 2 h), a sustained re lease preparation of the drug was devel oped, which can be given twice daily for long-term treatment. The present study was performed in order to compare the antiasthmatic effects and side-effects of a continuous 14-day enprofylline adminis tration with theophylline treatment.…”

Section: Introductionmentioning

confidence: 99%

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Enprofylline and Theophylline Slow-Eroding Tablets in the Treatment of Asthma: A Comparison

1986

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Fifteen asthmatic outpatients were randomly treated during two periods of 14 days each with sustained-release preparations of either enprofylline (3-propyl-xanthine) or theophylline (Theo-Dur®) in a double-blind crossover study. After 4 days of treatment the mean daily doses of enprofylline and theophylline, which were 14.1 and 16.2 mg/kg/day, produced mean plasma concentrations of 4.9 and 12.7 μg/ml, respectively. Taking into account all the parameters used to evaluate the antiasthmatic effects, the peak expiratory flow, the number of puffs used from a β-agonist aerosol, the asthma symptom score and the patients’ preferred period, enprofylline was found to be better than theophylline. Enprofylline produced more headaches during the 1st week than theophylline did. However, during the 2nd week the score for headaches decreased to the same level as in the theophylline treatment group. Thus, enprofylline and theophylline seem to have comparable bronchodilator properties and side-effects in the long-term treatment of asthma

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“…It also appears that headache and nausea, the side-effects most commonly seen after single doses or during short treatment with enprofylline, are subject to adaptation during oral long-term treatment with the drug (Laursen et al 1985). One may still speculate that this adaptation may not be effective in the case of a sudden high plasma peak of enprofylline.…”

Section: Discussionmentioning

confidence: 99%

Effects of Ampicillin on the Elimination of Enprofylline in Man

Paulsen

Borgå

Andersson

1987

Pharmacology & Toxicology

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The effect of intravenously administered ampicillin on plasma levels and renal clearance of enprofylline was investigated in seven young and six elderly volunteers. On one occasion, each subject received 2 g of ampicillin intravenously, and serum concentrations of ampicillin were followed for 4 hours. On a separate occasion, a loading infusion of enprofylline was administered over 60 min., aiming at a plasma level of 2 micrograms/ml, and followed by a maintenance infusion. During this an infusion of 2 g of ampicillin was given for 10 min., and subsequently, renal clearance and plasma levels of enprofylline were followed for 4 hours. Plasma enprofylline levels increased significantly in the subjects after ampicillin infusion, but the effects on renal clearance of enprofylline were not statistically significant. The magnitude of the effects on enprofylline plasma levels and renal clearance from high doses of ampicillin do not suggest that interaction with beta-lactam antibiotics will be a serious problem for patients on enprofylline treatment.

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Comparison of oral enprofylline and theophylline in asthmatic patients

Cited by 17 publications

References 10 publications

Maximally effective plasma concentrations of enprofylline and theophylline during constant infusion.

Maximally effective plasma concentrations of enprofylline and theophylline during constant infusion.

Enprofylline and Theophylline Slow-Eroding Tablets in the Treatment of Asthma: A Comparison

Effects of Ampicillin on the Elimination of Enprofylline in Man

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