Comparison of oral and vaginal misoprostol for cervical ripening before manual vacuum aspiration of first trimester pregnancy under local anesthesia: a randomized placebo-controlled study

Cervical priming with misoprostol before manual vacuum aspiration versus electric vacuum aspiration for first‐trimester surgical abortion

“…Group III experienced the least intraoperative blood loss and, although group IV experienced more intraoperative blood loss, the total intraoperative loss in the misoprostol groups was less than the total loss in the placebo groups. This finding is similar to those from a previous study in which misoprostol was administered before surgical evacuation [13]. The decrease in time required for cervical dilation in the misoprostol versus the placebo groups was the result of pharmacologic ripening of the cervix, and in the MVA groups versus the EVA groups it could have been because of the ease of technique.…”

“…The decrease in time required for cervical dilation in the misoprostol versus the placebo groups was the result of pharmacologic ripening of the cervix, and in the MVA groups versus the EVA groups it could have been because of the ease of technique. It was also observed that both groups that underwent MVA (I and III) had shorter operative time and less blood loss, and more women required no additional cervical dilation compared with the EVA groups (II and IV), as observed earlier [13], although the findings were not significant.…”

Cervical ripening before operative hysteroscopy in premenopausal women: a randomized, double-blind, placebo-controlled comparison of vaginal and oral misoprostol

“…The largest Hegar dilator inserted without resistance. most studies in which 400 mg of misoprostol was administered either orally (6,15,24,25) or vaginally (26). These results were different from those of Choksuchat et al (11), who reported a mean cervical width of 5.1 mm and 5.6 mm after oral and vaginal misoprostol, respectively.…”

“…However, these results should be interpreted with caution, because the study was underpowered for evaluating the side effects between both treatment regimens. Cakir et al (26) reported fewer side effects in women given vaginal misoprostol (400 mg) for first-trimester pregnancy termination when compared with women who received the same amount orally. In three of our patients, the only important undesired effect of vaginal misoprostol was excessive cervical dilatation and softening, which led to cervical fluid leakage.…”

Role of Sublingual Misoprostol for Cervical Priming in First Trimester Medical Termination of Pregnancy

“…The various route of misoprostol administration have been studied and compared with each other regarding their efficacy, pharmacokinetic properties and side effects profile to find the most appropriate route of its administration for cervical priming. Major studies have evaluated the misoprostol by oral and vaginal route [4][5][6]. Though vaginal misoprostol is found to be more effective due to its slow and more constant absorption through the vaginal mucosa, oral misoprostol has higher patient acceptability because it avoids the pain and discomfort associated with its administration through vaginal route [7].…”