Comparison of Optical Coherence Tomography Angiography and Indocyanine Green Angiography in Uveitis

Abstract

Optical Coherence Tomography Angiography (OCTA) has emerged as a useful modality for the diagnosis and management of uveitic diseases, but comparisons with other imaging modalities in uveitis are limited. The purpose of this study is to compare hypocyanescent lesions on Indocyanine Green Angiography (ICGA) to choriocapillaris flow deficits on OCTA in eyes with posterior and panuveitis. En-face 6x6 OCTA images of the choriocapillaris and mid-phase ICGA images from patients with posterior and panuveitis were reviewed and images were quantitatively compared. Lesion(s) on ICGA and OCTA images were outlined, binarized and then overlapped to determine the Dice similarity coefficient (DSC). Measurements of lesion morphology were compared using Bland-Altman analysis contrasting four primary features: lesion number (LN), lesion density (LD%), lesion circularity (LCi) and mean lesion size (MLS). A total of 36 eyes from 26 patients were analyzed. The overall agreement in spatial overlap between lesions from ICG and OCTA was classified as “good” [DSC ≥ 0.7] (mean DSC = 0.744; 95% confidence interval [0.679, 0.809]). No significant differences were noted between the LN, LD%, LCi, and MLS. Overall, OCTA appears to be comparable measure of choriocapillaris flow deficits in patients with posterior and panuveitis compared with hypocyanescent lesions on ICGA.