Comparison of Optical Coherence Tomography and Scanning Laser Polarimetry in Glaucoma, Ocular Hypertension, and Suspected Glaucoma

Halkiadakis, Ioannis; Kipioti, Athina; Emfietzoglou, Ioannis; Grigoropoulos, Vlassis; Katsis, Athanasios; Alimisi, Sotiria; Vergados, Ioannis; Theodossiadis, Panagiotis; Theodossiadis, George

doi:10.3928/15428877-20080301-09

Cited by 6 publications

(3 citation statements)

References 25 publications

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“…The NFI was described as a very sensitive index of glaucomatous damage with the highest area under the curve (AUC), in a few studies. [18–20] In our study the greatest change was noted in the NFI, postoperatively. For patients with documented advanced or moderate glaucoma, post cataract surgery, the apparent decrease in the NFI value would give a false indication of clinical improvement.…”

Section: Discussionsupporting

confidence: 46%

Effect of cataract surgery on retinal nerve fiber layer thickness parameters using scanning laser polarimetry (GDxVCC)

Dada

Behera

Agarwal

et al. 2010

Indian J Ophthalmol

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Purpose:To study the effect of cataract extraction on the retinal nerve fiber layer (RNFL) thickness, and assessment by scanning laser polarimetry (SLP), with variable corneal compensation (GDx VCC), at the glaucoma service of a tertiary care center in North India.Materials and Methods:Thirty-two eyes of 32 subjects were enrolled in the study. The subjects underwent RNFL analysis by SLP (GDx VCC) before undergoing phacoemulsification cataract extraction with intraocular lens (IOL) implantation (Acrysof SA 60 AT) four weeks following cataract surgery. The RNFL thickness parameters evaluated both before and after surgery included temporal, superior, nasal, inferior, temporal (TSNIT) average, superior average, inferior average, and nerve fiber index (NFI).Results:The mean age of subjects was 57.6 ± 11.7 years (18 males, 14 females). Mean TSNIT average thickness (μm) pre- and post-cataract surgery was 49.2 ± 14.1 and 56.5 ± 7.6 (P = 0.001). There was a statistically significant increase in RNFL thickness parameters (TSNIT average, superior average, and inferior average) and decrease in NFI post-cataract surgery as compared to the baseline values. Mean NFI pre- and post-cataract surgery was 41.3 ± 15.3 and 21.6 ± 11.8 (P = 0.001).Conclusions:Measurement of RNFL thickness parameters by scanning laser polarimetry is significantly altered following cataract surgery. Post the cataract surgery, a new baseline needs to be established for assessing the longitudinal follow-up of a glaucoma patient. The presence of cataract may lead to an underestimation of the RNFL thickness, and this should be taken into account when analyzing progression in a glaucoma patient.

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Section: Discussionsupporting

confidence: 46%

Effect of cataract surgery on retinal nerve fiber layer thickness parameters using scanning laser polarimetry (GDxVCC)

Dada

Behera

Agarwal

et al. 2010

Indian J Ophthalmol

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“…In a previous study, Zangwill and colleagues14 compared RNFL thickness measured by OCT with stereophotography of the optic disk and VF in normal eyes, patients with ocular hypertension, patients with suspected glaucoma, and glaucomatous patients and reported that average RNFL thickness seems to be a useful quantitative value for glaucoma diagnosis and follow-up, as an important correlation of 35%–45% between mean deviation of Humphrey achromatic perimetry and RNFL thickness was found. According to the results of our study, average RNFL thickness does not have a strong correlation with the indices of the VF, except in patients with progressive structural alterations (P < 1%) detected with OCT.…”

Section: Discussionmentioning

confidence: 99%

Comparative studies of RNFL thickness measured by OCT with global index of visual fields in patients with ocular hypertension and early open angle glaucoma

Taliantzis¹,

Papaconstantinou²,

Koutsandrea³

et al. 2009

OPTH

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Purpose:To compare the functional changes in visual fields with optical coherence tomography (OCT) findings in patients with ocular hypertension, open angle glaucoma, and suspected glaucoma. In addition, our purpose is to evaluate the correlation of global indices with the structural glaucomatous defect, to assess their statistical importance in all the groups of our study, and to estimate their validity to the clinical practice.Methods:One hundred sixty nine eyes (140 patients) were enrolled. The patients were classified in three groups. Group 1 consisted of 54 eyes with ocular hypertension, group 2 of 42 eyes with preperimetric glaucoma, and group 3 of 73 eyes with chronic open angle glaucoma. All of them underwent ophthalmic examination according to a prefixed protocol, OCT exam (Stratus 3000) for retinal nerve fiber layer (RNFL) thickness measurement with fast RNFL thickness protocol and visual fields (VF) examination with Octopus perimeter (G2 program, central 30–2 threshold strategy). Pearson correlation was calculated between RNFL thickness and global index of VF.Results:A moderate correlation between RNFL thickness and indices mean sensitivity (MS), mean defect (MD) and loss variance (LV) of VF (0.547, −0.582, −0.527, respectively; P <0.001) was observed for all patients. Correlations of the ocular hypertension and preperimetric groups are weak. Correlation of RNFL thickness with global indices becomes stronger as the structural alterations become deeper in OCT exam. Correlation of RNFL thickness with the global index of VF, in respective segments around optic disk was also calculated and was found significant in the nasal, inferior, superior, and temporal segments.Conclusion:RNFL average thickness is not a reliable index for early diagnosis of glaucoma and for the follow-up of patients with ocular hypertension. Segmental RNFL thickness seems to be a more reliable index. Deep structural alterations with OCT examination constitute an important indication of early functional changes, even if they are not still detected with achromatic perimetry. The MD index of VF seems to be more sensitive for the follow-up of patients with ocular hypertension.

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“…Το OCT προσφέρει τη δυνατότητα ποσοτικής και ποιοτικής ανάλυσης του πάχους των νευρικών ινών . Μια μελέτη που έγινε από τον Halkiadakis I et al(391) στην οποία μετρήθηκε το πάχος των νευρικών ινών με OCT και με Scanning Laser Polarimetry (SLP) σε φυσιολογικά άτομα, ασθενείς ύποπτους για γλαύκωμα και με γλαυκωματικές αλλοιώσεις έδειξε πως το μέσο πάχος των νευρικών ινών σχετίζεται καλά μόνο για τους ασθενείς με προχωρημένες γλαυκωματικές αλλοιώσεις. Από τη μελέτη μας προέκυψε μια μέτρια συσχέτιση στατιστικά σημαντική μεταξύ του μέσου πάχους των νευρικών περιθηλαίων ινών και των γενικών δεικτών του οπτικού πεδίου για το σύνολο των ατόμων που έλαβαν μέρος και που άνηκαν σε διάφορα στάδια της εξέλιξης του γλαυκώματος.…”

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Σύγκριση Των Αλλοιώσεων Του Οπτικού Πεδίου, Σε Ασθενείς Με Γλαύκωμα, Με Τα Ευρήματα Του OCT

Ταλιαντζής¹

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Comparison of Optical Coherence Tomography and Scanning Laser Polarimetry in Glaucoma, Ocular Hypertension, and Suspected Glaucoma

Abstract: RNFL thickness measurements obtained with OCT and SLP-VCC correlate well only in eyes with more advanced glaucomatous damage. The nerve fiber indicator parameter derived by SLP correlated best with mean deviation.

Cited by 6 publications

References 25 publications

Effect of cataract surgery on retinal nerve fiber layer thickness parameters using scanning laser polarimetry (GDxVCC)

Effect of cataract surgery on retinal nerve fiber layer thickness parameters using scanning laser polarimetry (GDxVCC)

Comparative studies of RNFL thickness measured by OCT with global index of visual fields in patients with ocular hypertension and early open angle glaucoma

Σύγκριση Των Αλλοιώσεων Του Οπτικού Πεδίου, Σε Ασθενείς Με Γλαύκωμα, Με Τα Ευρήματα Του OCT

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