Comparison of optic nerve head topography findings in eyes with non-arteritic anterior ischemic optic neuropathy and eyes with glaucoma

Abstract

Stratus OCT detected significant quantitative differences in RNFL thickness between glaucomatous and NAION eyes, both conditions with hemifield defects. These differences might hold a clue in understanding the processes involved in optic nerve injury.

Optical Coherence Tomography (OCT): Imaging the Visual Pathway as a Model for Neurodegeneration

“…However, other studies have demonstrated a tendency of NAION to involve the superior quadrant of RNFL, particularly in those patients with inferior altitudinal loss [78,79]. In the acute phase, the thickness of the RNFL can be dramatically increased to nearly double the values seen in the unaffected fellow eye [78,79]. In one study of patients with NAION, arteritic anterior ischemic optic neuropathy (AAION) and open angle glaucoma, patients with open angle glaucoma had greater cup size and thinning of the neuroretinal rim than those with NAION and AAION.…”

“…One important characteristic of NAION is a small or absent cup in the fellow eye. In most OCT studies, NAION patients have smaller optic cups than controls [75][76][77][78][79]. The reduction in cup size appears to represent an anatomical risk factor for the development of NAION.…”

“…The reduction in cup size appears to represent an anatomical risk factor for the development of NAION. There have been conflicting results regarding the reduction of total disc area in patients with NAION, with some studies showing a decrease in disc area size [79][80][81]. Variability in these observations may reflect differences in the technology used to measure disc area, with some studies using OCT technology while others used the HRT.…”

Optical Coherence Tomography Study of Experimental Anterior Ischemic Optic Neuropathy and Histologic Confirmation

“…[16][17][18] The high-resolution spectraldomain optical coherence tomography (SD-OCT), also known as the Fourier domain-OCT, can capture microstructures in the rodent retina at up to 100 times the speed of the older timedomain OCT. OCT has been used to approximate optic nerve anatomy by measuring the thickness of the axons of the RGCs, which reside in the retinal nerve fiber layer. [19][20][21][22] In animal studies, OCT has increasingly been used to track anatomic changes of retinal and optic nerve diseases, 18,[23][24][25][26] including Leber's congenital amaurosis, retinal dystrophies, [27][28][29] optic nerve crush, 30,31 N-methyl-D-aspartate (NMDA)-induced retinal ganglion cell loss, 32 optic neuritis, 33 ischemic optic neuropathy, 34,35 and different models of glaucoma. 5,36 In some studies, OCT images are quantitatively or qualitatively comparable to histologic sections at same time points.…”

Tomography findings in optic nerve head and retina in differential diagnosis between normal-tension glaucoma and ischemic optic neuropathies

“…Существует мнение, что истончение СНВС при ИОН встречается в височном, верхнем и назальном квадрантах, что коррелирует с различными класси-ческими паттернами дефектов полей зрения [8,18]. Выявлено, что толщина СНВС в квадранте, соответ-ствующем неповрежденной полусфере поля зрения, значительно меньше при глаукоме, чем при ИОН [19]. Площадь нейроретинального пояска при глау-коме, определяемая с помощью лазерной сканиру-ющей офтальмоскопии, коррелирует с толщиной СНВС (данные ОКТ) в целом и в, большинстве сек-торов в отличие от исхода ИОН [20].…”