Comparison of One-, Two-, and Three-Dimensional Measurements of Childhood Brain Tumors

Abstract

Detection of partial responses was not influenced by the measurement method, but estimating time to disease progression may be method dependent for childhood brain tumors.

Buscando Una Curva General De Respuesta a La Quimioterapia Basada en La Evaluación Radiológica Con Criterio Recist

“…Mientras los primeros estudios que comparaban el uso de uno o dos diámetros para el seguimiento de una lesión revelaban una concordancia de alrededor de un 95% (4)(5)(6)(7) , estudios posteriores han encontrado rangos de concordancia entre 0,68 y 0,77 (3) y han destacado que la medida de un solo diámetro no rescata las características de los cambios de forma que pueden ocurrir en una lesión.…”

Pharmacometric Modeling of Liver Metastases' Diameter, Volume, and Density and Their Relation to Clinical Outcome in Imatinib‐Treated Patients With Gastrointestinal Stromal Tumors

“…At the time of the RECIST update in 2009 (RECIST 1.1), the lack of rigorous clinical validation and of widespread access to these newer imaging approaches prevented their implementation and adoption. However, in recent years, a number of publications have demonstrated the high reproducibility and interobserver reliability of volume measurements using semiautomated tumor segmentation technique implemented in commercially available15, 16, 17, 18 or in‐house software 19. The estimated ellipsoidal volume has been suggested as an approximation for software‐calculated actual volume to overcome limitations related to software availability and has shown good correlation to actual volume 15, 18.…”

“…The estimated ellipsoidal volume has been suggested as an approximation for software‐calculated actual volume to overcome limitations related to software availability and has shown good correlation to actual volume 15, 18. Moreover, for a number of cancers 3D assessments enable to capture finer changes in tumor size,17, 18 and better correlates to long‐term clinical outcome, such as OS,2, 18, 21 compared to 1D measurements. Such results were supported by Schiavon et al .,15 showing that ellipsoidal volume provides a satisfactory approximation for the actual volume of liver metastases in imatinib‐treated GIST.…”

Evaluation of the response to treatment of solid tumours – a consensus statement of the International Cancer Imaging Society

“…It is uncertain what modality was used in these trials, what methodology was used to calculate the measurements and how many tumours or metastases were actually measured. Subsequent data have demonstrated some concordance between RECIST and WHO for best overall response but limited or no concordance between RECIST and WHO for time to progression (Schwartz et al, 2001;Warren et al, 2001;Prasad et al, 2002;Wang et al, 2003). This criterion is increasingly being used as a surrogate end point and the lack of correlation between RECIST and WHO is of concern.…”

“…However, the difficulty or impact of the change in response assessment for disease progression was not proven or justified in the guidelines. Clearly, such a discrepancy will arguably result in longer periods of progression-free disease and specifically in changes in time to progression between new trials using the RECIST criteria and those using WHO criteria (Warren et al, 2001;Schwartz et al, 2003a).…”