Comparison of One-Day Versus One-Hour Application of Topical Gatifloxacin in Eliminating Conjunctival Bacterial Flora

Moss, Jason M.; Nguyen, David H.; Liu, Yueyi I.; Singh, Kuldev; Montague, Artis A.; Egbert, Peter R.; Kaspar, Herminia Miño de; Ta, Christopher N.

doi:10.1016/j.ophtha.2008.06.024

Cited by 31 publications

(18 citation statements)

References 8 publications

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“…If conjunctival studies are considered in the prophylaxis of postoperative endophthalmitis, the administration of fluoroquinolones four times in the 2 h before surgery is as effective as four times one day before surgery, but the use of both schemes together is even more effective [20]. Although it was proven that a 1-day preoperative antibiotic prophylaxis is as effective as when it is used for 3 days [11], the 1-day course of prophylactic antibiotics results in more bacterial resistance [20].…”

Section: Discussionmentioning

confidence: 99%

“…Although it was proven that a 1-day preoperative antibiotic prophylaxis is as effective as when it is used for 3 days [11], the 1-day course of prophylactic antibiotics results in more bacterial resistance [20]. Thus, the use of antibiotics for several days prior to surgery would seem to be the most effective strategy for postoperative endophthalmitis prophylaxis.…”

Section: Discussionmentioning

confidence: 99%

“…Moss et al [20] compared 1-day (four times) vs. 1-h (three times) application of topical gatifloxacin. Although they concluded that both 1-h and 1-day topical gatifloxacin use could be effective in conjunctival bacteria flora reduction, they recommended that both strategies be combined for more effective prophylaxis.…”

Section: Key Pointsmentioning

confidence: 99%

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A review of preoperative manoeuvres for prophylaxis of endophthalmitis in intraocular surgery

Grzybowski

Kuklo

Pieczyński

et al. 2016

Current Opinion in Ophthalmology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A review of preoperative manoeuvres for prophylaxis of endophthalmitis in intraocular surgery

Grzybowski

Kuklo

Pieczyński

et al. 2016

Current Opinion in Ophthalmology

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“…Recent studies found that these are not an advantage in terms of reducing the rate of endophthalmitis [8,9]. However, since there is a rationale for their use (eliminating the bacterial conjunctival flora and reducing the pathogenicity of the surviving bacteria) [14,15], it is not surprising that according to the Green-Simms study [16], around 2/3 of the retinal specialists use them for IVT endophthalmitis prophylaxis.…”

Section: Discussionmentioning

confidence: 99%

Impact of Antibiotic Prophylaxis on the Conjunctival Flora of Patients Receiving Intravitreal Antivascular Endothelial Growth Factor Injections

Passarinho

Portelinha

Pacheco³

et al. 2014

Ophthalmologica Extra

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Purpose: To characterize the conjunctival flora of patients receiving antibiotics before intravitreal (IVT) antivascular endothelial growth factor injections. Methods: We studied 31 eyes of 30 patients with neovascular age-related macular degeneration scheduled to receive IVT antivascular endothelial growth factor injections. The patients were all given a preinjection of topical ofloxacin 3 days before the injections. Conjunctival cultures from the injection eye were collected before antibiotic prophylaxis (sample A) and on the injection day, both before (sample B) and after (sample C) povidone-iodine (PVI) application. Results: Culture positivity was significantly different between samples A (50%) and C (4.5%; p < 0.001) as well as samples B (30.4%) and C (4.5%; p = 0.015), but not between samples A and B. Positive cultures were mainly coagulase-negative staphylococci (CNS; 57% of sample A, 62.5% of sample B and 100% of sample C) susceptible to vancomycin (100%), moxifloxacin (90%), levofloxacin (70%) and ofloxacin (60%). Conclusion: In our study, most of the bacteria isolated were CNS. PVI application but not antibiotics reduced culture positivity.

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“…Literature in support of the use of topical preoperative prophylaxis have shown a reduction in the number of ocular surface flora [18,19], and achievement of therapeutic intraocular concentrations of antibiotics, especially newer fourth-generation fluoroquinolones such as moxifloxacin and gatifloxacin [20,21]. Nevertheless, in Singapore, a variety of topical preoperative antibiotics were used, including tobramycin, a bactericidal aminoglycoside, the bacteriostatic chloramphenicol, and levofloxacin and moxifloxacin.…”

Section: Discussionmentioning

confidence: 99%

Survey of practice preference pattern in antibiotic prophylaxis against endophthalmitis after cataract surgery in Singapore

Han

Chee

2012

Int Ophthalmol

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To determine practice preference of prophylaxis against post-cataract surgery endophthalmitis in Singapore. Prospective nationwide survey of all registered ophthalmologists through telephone, e-mail or postal questionnaires. A response rate of 76.6% was obtained from 121 out of 158 eligible ophthalmologists. Awareness of the recommendations made by the European Society of Cataract and refractive surgeons (ESCRS) endophthalmitis study was noticed in 98 (81.0%) respondents. Out of the 121 respondents, 85 (70.2%) do not use intracameral antibiotic prophylaxis. Of the 36 respondents using intracameral antibiotics, 34 (94.4%) used cefazolin. The reasons cited for not adopting intracameral antibiotic prophylaxis included financial costs, the relatively low risk of endophthalmitis after cataract surgery, the burden of dilution and the fear of toxic anterior segment syndrome. More than half (65, 53.7%) of respondents would use intracameral antibiotic prophylaxis if it were available commercially. The most commonly practiced prophylaxis (94, 77.7%) was preoperative topical antibiotics. The majority of ophthalmologists in Singapore have not adopted the use of intracameral antibiotics, with most preferring the use of pre- and postoperative prophylactic topical antibiotics, despite knowledge of the ESCRS endophthalmitis study.

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Comparison of One-Day Versus One-Hour Application of Topical Gatifloxacin in Eliminating Conjunctival Bacterial Flora

Cited by 31 publications

References 8 publications

A review of preoperative manoeuvres for prophylaxis of endophthalmitis in intraocular surgery

A review of preoperative manoeuvres for prophylaxis of endophthalmitis in intraocular surgery

Impact of Antibiotic Prophylaxis on the Conjunctival Flora of Patients Receiving Intravitreal Antivascular Endothelial Growth Factor Injections

Survey of practice preference pattern in antibiotic prophylaxis against endophthalmitis after cataract surgery in Singapore

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