Comparison of ondansetron and metoclopramide antiemetic prophylaxis in maxillofacial surgery patients

Talesh, Koroush Taheri; Motamedi, Mohammad Hosein Kalantar; Kahnamouii, Shiva Solahaye

doi:10.1016/j.tripleo.2010.04.034

Cited by 9 publications

(3 citation statements)

References 14 publications

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“…Oral and maxillofacial surgical procedures under general anesthesia have a relatively common complication of postoperative nausea and vomiting (PONV). Postoperative vomiting may predispose patients to increased pain, bleeding, dehydration, electrolyte imbalance, and delayed wound healing 1 . Thus, it is prudent to minimize or prevent vomiting in such patients.…”

Section: Introductionmentioning

confidence: 99%

“…The prophylactic efficacy of ondansetron in preventing PONV has already been established in various surgical procedures requiring general anesthesia 3 4 5 6 7 . However, with regard to oral and maxillofacial surgical procedures under general anesthesia, some studies have shown ineffectiveness of 4 mg ondansetron prophylaxis, whereas another study has shown that ondansetron is more effective than metoclopramide 1 8 9 . Therefore, the efficacy of ondansetron in preventing PONV has not been clearly established in patients undergoing oral and maxillofacial surgical procedures under general anesthesia.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of ondansetron and granisetron for antiemetic prophylaxis in maxillofacial surgery patients receiving general anesthesia: a prospective, randomised, and double blind study

Savant¹,

Khandeparker²,

Berwal

et al. 2016

J Korean Assoc Oral Maxillofac Surg

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ObjectivesTo compare the efficacy of intravenous ondansetron (4 mg, 2 mL) and granisetron (2 mg, 2 mL) for preventing postoperative nausea and vomiting (PONV) in patients during oral and maxillofacial surgical procedures under general anesthesia.Materials and MethodsA prospective, randomized, and double blind clinical study was carried out with 60 patients undergoing oral and maxillofacial surgical procedures under general anesthesia. Patients were divided into two groups of 30 individuals each. Approximately two minutes before induction of general anesthesia, each patient received either 4 mg (2 mL) ondansetron or 2 mg (2 mL) granisetron intravenously in a double blind manner. Balanced anesthetic technique was used for all patients. Patients were assessed for episodes of nausea, retching, vomiting, and the need for rescue antiemetic at intervals of 0-2, 3, 6, 12, and 24 hours after surgery. Incidence of complete response and adverse effects were assessed at 24 hours postoperatively. Data was tabulated and subjected to statistical analysis using the chi-square test, unpaired t-test, or the Mann-Whitney U-test as appropriate. A P-value less than 0.05 was considered statistically significant.ResultsThere was no statistically significant difference between the two groups for incidence of PONV or the need for rescue antiemetic. Both study drugs were well tolerated with minimum adverse effects; the most common adverse effect was headache. The overall incidence of complete response in the granisetron group (86.7%) was significantly higher than the ondansetron group (60.0%).ConclusionGranisetron at an intravenous dose of 2 mg was found to be safe, well tolerated, and more effective by increasing the incidence of complete response compared to 4 mg intravenous ondansetron when used for antiemetic prophylaxis in maxillofacial surgery patients receiving general anesthesia. Benefits of granisetron include high receptor specificity and high potency, which make it a valuable alternative to ondansetron.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison of ondansetron and granisetron for antiemetic prophylaxis in maxillofacial surgery patients receiving general anesthesia: a prospective, randomised, and double blind study

Savant¹,

Khandeparker²,

Berwal

et al. 2016

J Korean Assoc Oral Maxillofac Surg

View full text Add to dashboard Cite

show abstract

“…Prophylactic use of antiemetic medications, such as ondansetron hydrochloride (Zofran), has been suggested as a way to prevent PONV. [45][46][47] These medications are serotonin receptor antagonists. One of the most challenging patients to manage postoperative nausea in is the tympanoplasty patient group.…”

Section: Antiemetic Medications For the Prevention Of Nausea And Vomimentioning

confidence: 99%

Best Practices for Management of Pain, Swelling, Nausea, and Vomiting in Dentoalveolar Surgery

Drew¹

2015

Oral and Maxillofacial Surgery Clinics of North America

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Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis

Weibel

Rücker

Eberhart

et al. 2020

Cochrane Database of Systematic Reviews

111

133

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Comparison of ondansetron and metoclopramide antiemetic prophylaxis in maxillofacial surgery patients

Cited by 9 publications

References 14 publications

Comparison of ondansetron and granisetron for antiemetic prophylaxis in maxillofacial surgery patients receiving general anesthesia: a prospective, randomised, and double blind study

Comparison of ondansetron and granisetron for antiemetic prophylaxis in maxillofacial surgery patients receiving general anesthesia: a prospective, randomised, and double blind study

Best Practices for Management of Pain, Swelling, Nausea, and Vomiting in Dentoalveolar Surgery

Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis

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