Comparison of Number Versus Ratio of Positive Lymph Nodes in the Assessment of Lymph Node Status in Extrahepatic Cholangiocarcinoma

Sakata, Jun; Wakai, Toshifumi; Matsuda, Yasunobu; Ohashi, Takuma; Hirose, Yuki; Ichikawa, Hiroshi; Kobayashi, Takashi; Minagawa, Masahiro; Kosugi, Shin‐ichi; Koyama, Yu; Akazawa, Kouhei; Ajioka, Yoichi

doi:10.1245/s10434-015-4609-x

Cited by 27 publications

(17 citation statements)

References 34 publications

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“…The coefficients of correlation and corresponding p values are listed in Supplementary Table . Lymph nodes status is a strong determinant of clinical outcomes for patients with various gastrointestinal cancers . Intriguingly, we noticed that a branching fucosylated triantennary N ‐glycan (peak9, AUC = 0.845) and a branching fucosylated tetra‐antennary N ‐glycan (peak12, AUC = 0.761) were positively correlated with lymph node involvement ( p < 0.05), whereas CA19‐9, the commonly used marker, was not related to this pathological feature.…”

Section: Resultsmentioning

confidence: 79%

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Serum N‐glycans outperform CA19‐9 in diagnosis of extrahepatic cholangiocarcinoma

et al. 2017

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Extensive efforts have been devoted to improve the diagnosis of extrahepatic cholangiocarcinoma (ECCA) due to its silent clinical character and lack of effective diagnostic biomarkers. Specific alterations in N-glycosylation of glycoproteins are considered a key component in cancer progression, which can serve as a distinct molecular signature for cancer detection. This study aims to find potential serum N-glycan markers for ECCA. In total, 255 serum samples from patients with ECCA (n = 106), benign bile tract disease (BBD, n = 60) and healthy controls (HC, n = 89) were recruited. Only 2 μL of serum from individual patients was used in this assay where the N-glycome of serum glycoproteins was profiled by DNA sequencer-assisted fluorophore-assisted capillary electrophoresis (DSA-FACE) technology. Multi-parameter models were constructed by combining the N-glycans and carbohydrate antigen 19-9 (CA19-9) which is currently used clinically. Quantitative analyses showed that among 13 N-glycan structures, the bifucosylated triantennary N-glycan (peak10, NA3F2) presented the best diagnostic performance for distinguishing ECCA from BBD and HC. Two diagnostic models (Glycotest1 and Glycotest2) performed better than single N-glycan or CA19-9. Additionally, two N-glycan structures (peak9, NA3Fb; peak12, NA4Fb) were tightly related to lymph node metastasis in ECCA patients. In conclusion, sera of ECCA showed relatively specific N-glycome profiling patterns. Serum N-glycan markers and models are novel, valuable and noninvasive alternatives in ECCA diagnosis and progression monitoring.

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Section: Resultsmentioning

confidence: 79%

“…As is well‐known, assessment of nodal status might harbor important prognostic information and guided adjuvant treatment . Correlation analyses and ROC curves indicated that a branching fucosylated triantennary N ‐glycan (peak9) and branching fucosylated tetra‐antennary N ‐glycan (peak12) were closely related with lymph metastasis.…”

Section: Discussionmentioning

confidence: 92%

Serum N‐glycans outperform CA19‐9 in diagnosis of extrahepatic cholangiocarcinoma

et al. 2017

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“…Substantial number of lymph nodes, resection is justified for appropriate staging of nodal ailment. We firmly assume that comprehensive localized lymphadenectomy definitely seems to be required for effective resection of extrahepatic cholangiocarcinoma [62].…”

Section: Surgical Resectionmentioning

confidence: 79%

“…In PHC, most often concomitant vascular resections and reconstruction are needed in order to achieve the negative margin. Our latest research implies that count of positive lymph nodes much better anticipates survival following surgical resection compared to lymph node resection in extrahepatic cholangiocarcinoma, given that lymph node assessment is enough [62]. Substantial number of lymph nodes, resection is justified for appropriate staging of nodal ailment.…”

Section: Surgical Resectionmentioning

confidence: 99%

Perihilar or (Hilar) Cholangiocarcinoma: Interventional to Surgical Management

Prasoon¹,

Miura²,

Yuza³

et al. 2019

Bile Duct Cancer

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Peri-hilar cholangiocarcinoma (PHC) or hilar cholangiocarcinoma (HCCA) characterizes a critical effort to assess significantly sick patients. The existing scenery and proof to the diagnosis and treatments for hilar cholangiocarcinoma are improving day by day. Patients with HCCA encounter numerous obstacles in acquiring efficient therapies. The condition is uncommon, and the majority patients don't have any distinct risk factors, doing selection process inadequate. The initial signs and symptoms in many cases are non-specific, and in many patients the tumors are not resectable because of involvement of the perihilar structures. MRI with MRCP offers further information about the extent of biliary involvement. Furthermore, endoscopic stenting and percutaneous drain could be useful for intricate hilar strictures. Surgical resections with negative margins are related to good likelihood of survival for patients representing with HCCA. Regardless of the accessibility of curative treatment strategies such as operative resection and liver transplantation, most sufferers with HCCA shows with repeated, metastases or locally advanced disease with a poor prognosis. Within this chapter, we have tried to elaborate the modalities of treatment from intervention to surgical approach for HCCA.

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“…In addition to some conventional demographic and clinicopathological factors, such as age, gender, tumor location, tumor differentiation, T and N staging, etc., the veri ed cancer-related prognostic factors, including Albumin to globulin ratio (AGR), Neutrophil to lymphocyte ratio (NLR), Platelet to lymphocyte ratio (PLR), Positive lymph nodes ratio (PRL), Low-density lipoprotein (LDL), and Prognostic Nutritional Index (PNI) are candidates of nomogram establishment. (25,26) Among them, six factors including age, gender, N stage (with modi ed), AGR, PRL, PNI were identi ed as independent prognostic factors by statistical Cox hazard regression analysis, and the Hazard Ratio (HR) of each factor displays the weight of score in the nomogram. (9) For demographic characteristics, we found that two factors, age and gender, were associated with OS of EC patients after radical esophagectomy, and thus were included into the establishment of nomogram.…”

Section: Roc Of Nomogram In Prediction Os Compared With Ajcc T Stage mentioning

confidence: 99%

A neotype nomogram based on accessible clinical indicators to predict the overall survival of esophageal cancer patients underwent radical resection

Zhu

et al. 2020

Preprint

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Background: Esophageal cancer (EC) is a malignant tumor with dreadful mortality, nomogram is a prognosis tool of great significance in therapeutic guidance and assessment. We aimed to establish a newly-built nomogram for OS prediction of EC patients with radical esophagectomy.Methods: A total of 311 EC patients underwent radical esophagectomy were retrospectively investigated with their survival and demographic and clinicopathological data. Patients were randomly divided into the primary and validation cohorts. The establishment of nomogram was based on Cox hazard regression analysis in primary cohort, the calibration curves and Harrell’s concordance index were performed to verify the predictive accuracy while ROC curves was adopted to reflect the efficacy of nomogram. Kaplan–Meier curves showed the clinical significance of risk classification system and Pearson correlation test was utilized to show the correlation between risk classification system and TNM staging.Results: The median OS and 5-year survival rate are 44 months and 29.8% in primary cohort. In validation cohort, they are 52 months and 27.1%, respectively. In Cox hazard regression analysis, we extracted six independent prognostic factors—age, gender, AGR, PRL, N stage, PNI—to establish the nomogram. The C-index of nomogram is 0.75 in primary cohort and 0.70 in validation cohort. Calibration curves indicated high consistency between accurate and predicted OS in both primary and validation cohorts. ROC curves showed a better efficacy of nomogram compared with AJCC T and N stage. The area under curve (AUC) of primary cohort is 0.801 and 0.727 in validation cohort. Patients in primary cohort were divided into three risk groups according to the nomogram score, the median OS between each group was significantly different. Analogical results were obtained in validation cohort. Furthermore, the risk classification system was strongly correlated to AJCC TNM staging system in total cohort (r2=0.647, P<0.001), and it also demonstrated a better OS prediction efficacy (AUC=0.742).Conclusions: We established a neotype nomogram and a relevant risk classification system with verified accuracy and efficacy in OS prediction of EC patients after radical esophagectomy. They may provide feasible value in prognosis assessment and treatment guidance prospectively.

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Comparison of Number Versus Ratio of Positive Lymph Nodes in the Assessment of Lymph Node Status in Extrahepatic Cholangiocarcinoma

Abstract: The number of positive lymph nodes predicts survival better than the LNR after resection of extrahepatic cholangiocarcinoma, provided that nodal evaluation is sufficient.

Cited by 27 publications

References 34 publications

Serum N‐glycans outperform CA19‐9 in diagnosis of extrahepatic cholangiocarcinoma

Serum N‐glycans outperform CA19‐9 in diagnosis of extrahepatic cholangiocarcinoma

Perihilar or (Hilar) Cholangiocarcinoma: Interventional to Surgical Management

A neotype nomogram based on accessible clinical indicators to predict the overall survival of esophageal cancer patients underwent radical resection

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