Comparison of novel hemostatic dressings with QuikClot combat gauze in a standardized swine model of uncontrolled hemorrhage

Rall, Jason M.; Cox, Jennifer; Songer, Adam G.; Cestero, Ramon F.; Ross, James D.

doi:10.1097/ta.0b013e318299d909

Cited by 81 publications

(59 citation statements)

References 11 publications

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“…The effectiveness and usefulness of QuikClot gauze and Celox gauze in the rapid control of massive bleeding has been repeatedly confirmed in experimental studies (Paltrinieri et al 2008), in hospital settings and on the battlefield in direct warfare (Devlin et al 2011, Rall et al 2013. Our study demonstrated the efficacy of both dressings in the control of bleeding from the injured femoral artery.…”

Section: Discussionsupporting

confidence: 49%

Thromboelastographic profile of goat blood after the experimental injury of the femoral artery and use of QuikClot gauze and Celox gauze dressings

Sobiech

Adamiak

Holak

et al. 2017

Polish Journal of Veterinary Sciences

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The aim of this study was to evaluate the suitability of thromboelastometry for the analysis of blood test results in goats after the use of hemostatic dressings to control massive bleeding. The study was carried out on 12 goats, 6 animals in each of two subgroups. In all experimental animals incision of the femoral artery was performed, and bleeding was controlled with QuikClot gauze in the first group and Celox gauze in the second group. Dressings were applied for 60 minutes. Blood samples for thromboelastometry were collected from the jugular vein before the incision and 60 min after the application of a dressing. Clotting time (CT), clot formation time (CFT), maximum clot firmness (MCF) and α angle ( o ) were measured in three standard ROTEM assays (system with generation of reaction curve, numerical parameters and size of the blood clot): intrinsic coagulation pathway (INTEM), extrinsic coagulation pathway (EXTEM) and functional fibrinogen (FIBTEM). Complete hemostasis of the injured femoral artery was found in all goats. No significant differences between pre-and post-incision thromboelastometric parameters were found in any tests in any of the groups, which indicates that the use of dressings was not associated with blood coagulation disorders. This study is the first to describe the use of thromboelastometry in goats for the assessment of clot formation and hemostatic disorders.

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Section: Discussionsupporting

confidence: 49%

Thromboelastographic profile of goat blood after the experimental injury of the femoral artery and use of QuikClot gauze and Celox gauze dressings

Sobiech

Adamiak

Holak

et al. 2017

Polish Journal of Veterinary Sciences

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“…other products have also been developed. While these agents have demonstrated superior efficacy in compressible hemorrhage control compared to regular gauze (10), no one alternative has shown clear superiority over others (11). Presently, the most frequently used hemostatic dressing is the combat Gauze ® , which combines surgical gauze with the aluminosilicate kaolin.…”

Section: Hemostatic Dressingsmentioning

confidence: 99%

A Decade of Advances in Military Trauma Care

et al. 2014

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Background: While combat casualty care shares many key concepts with civilian trauma systems, its unique features mandate certain practices that are distinct from the civilian ones. Methods: This is a review of the most current literature on combat casualty care, based on computer database searches for studies on combat casualty care and military medicine. Studies were selected for inclusion in this review based on their relevance and contribution. Results: Over the last decade, meticulous, international data collection and research efforts have led to significant improvements in military trauma care. Combat medicine has focused on the causes of preventable deaths and targeted on bleeding control and resuscitation strategies, as well as improved evacuation. En route care and forward surgical interventions have resulted in unprecedented low fatality rates and the saving of more lives. Conclusion: This overview of the developments in combat casualty care in recent years emphasizes medical practices that are characteristic of combat medicine, yet with the potential to save lives in other scenarios, as well.

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“…Hemostatic agents are used in both military and civilian medicine during intervention and rescue operations (Ran et al 2010, Travers et al 2012. The effectiveness of hemostatic dressings such as QuikClot, Chitoauze and Celox gauze has been used in combat and in laboratory analyses, but there is still scanty information (Rall et al 2013). …”

Section: Introductionmentioning

confidence: 99%

Response of the coagulation system after application of hemostatic dressings in an animal model

Jastrzębski

Adamiak²,

Pomianowski³

et al. 2014

Polish Journal of Veterinary Sciences

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Comparison of novel hemostatic dressings with QuikClot combat gauze in a standardized swine model of uncontrolled hemorrhage

Cited by 81 publications

References 11 publications

Thromboelastographic profile of goat blood after the experimental injury of the femoral artery and use of QuikClot gauze and Celox gauze dressings

Thromboelastographic profile of goat blood after the experimental injury of the femoral artery and use of QuikClot gauze and Celox gauze dressings

A Decade of Advances in Military Trauma Care

Response of the coagulation system after application of hemostatic dressings in an animal model

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