Comparison of non-schistosomal colorectal cancer and schistosomal colorectal cancer

Abstract

Aim: The purpose of this study was to compare clinicopathological features of patients with non-schistosomal and schistosomal colorectal cancer to explore the effect of schistosomiasis on colorectal cancer (CRC) patients' clinical outcomes. Methods: Three hundred fifty-one cases of CRC were retrospectively analyzed in this study. Survival curves were constructed by using the Kaplan-Meier (K-M) method. Univariate and multivariate Cox proportional hazard regression models were performed to identify associations with outcome variables. Results: Colorectal cancer patients with schistosomiasis (CRC-S) were significantly older (P < 0.001) than the patients without schistosomiasis (CRC-NS). However, there were no significant differences between CRC-S and CRC-NS patients in other clinicopathological features. Schistosomiasis was associated with adverse overall survival (OS) upon K-M analysis (P = 0.0277). By univariate and multivariate analysis, gender (P = 0.003), TNM stage (P < 0.001), schistosomiasis (P = 0.025), lymphovascular invasion (P = 0.030), and lymph nodes positive for CRC (P < 0.001) were all independent predictors in the whole cohort. When patients were stratified according to clinical stage and lymph node metastasis state, schistosomiasis was also an independent predictor in patients with stage III-IV tumors and in patients with lymph node metastasis, but not in patients with stage I-II tumors and in patients without lymph node metastasis. Conclusion: Schistosomiasis was significantly correlated with OS, and it was an independent prognostic factor for OS in the whole cohort. When patients were stratified according to clinical stage and lymph node metastasis state, schistosomiasis was still an independently unfavorable prognosis factor for OS in patients with stage III-IV tumors or patients with lymph node metastasis.

Prognostic Value of Tumor-Infiltrating Lymphocytes in Schistosomiasis-Associated Colorectal Cancer

“…Ye et al [32] reported that intestinal schistosomiasis was a risk factor for CRC and that the lesions caused by the disease might be considered precancerous. Our previous study demonstrated that schistosomiasis was an independent worse prognosis for OS in CRC patients [13]. In this study, we further con rmed that schistosomiasis was an independent unbene cial prognosis factor for OS in CRC patients.…”

“…However, all these studies were based on the analysis of data of clinicopathological characteristics, in ammation based prognostic systems have been rarely reported in the literature. Besides, our previous study showed that schistosomiasis was an independent poor prognosis for CRC patients [13], and clinicopathological characteristics were differences between patients with schistosomal and nonschistosomal CRC [13]. But the evidence that chronic in ammatory process occurring in schistosomiasis playing an important role in CRC progression is not providing.…”

Polarization of intestinal tumour-associated macrophages regulates the development of schistosomal colorectal cancer

“…Schistosomiasis may affect the occurrence and development of CRC 48 , 49 . We report here that in patients with schistosomal CRC, schistosomiasis may promote the development of CRC by affecting the transformation of TAMs to the M2 phenotype.…”

Correlation between schistosomiasis and CD8+ T cell and stromal PD-L1 as well as the different prognostic role of CD8+ T cell and PD-L1 in schistosomal-associated colorectal cancer and non-schistosomal-associated colorectal cancer

“…This retrospective analysis includes 338 patients with resected primary CRC at Qingpu Branch of Zhongshan Hospital affiliated to Fudan University, from January 2008 to August 2016. All of the operations followed the principle described previously [ 23 ]. The inpatient medical records and pathological reports were reviewed from the pathological system and Qingpu District Center for Disease Control and Prevention, and the patients were followed up by telephone.…”

“…OS is defined as the interval from the surgical operation date to the last follow-up or death caused by CRC. Inclusion criteria are as previously described [ 23 ]. Two expert pathologists reviewed HE-stained slides to determine the diagnosis and to restage the tumors according to the eighth edition of American Joint Committee on Cancer (AJCC).…”