Comparison of Nitric Oxide Release and Endothelium-Derived Hyperpolarizing Factor–Mediated Hyperpolarization Between Human Radial and Internal Mammary Arteries

He, Guo‐Wei; Liu, Zhigang

doi:10.1161/hc37t1.094930

Cited by 123 publications

(88 citation statements)

References 24 publications

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“…Other studies suggest that the endothelial function of radial artery is similar to that of the IMA (25,26). However, other investigators have reported differences in endothelium-derived NO release and hyperpolarizing factor in the IMA and radial artery (27,28 This has led researchers to look for experimental models for functional experiments in an attempt to avoid the detrimental impact of these cardiovascular risk factors on vasoreactivity. Recently, we addressed the neurogenic contractions produced in porcine radial artery using a combined histological/functional approach (4).…”

Section: +mentioning

confidence: 99%

Modulation of Noradrenergic Neurotransmission in Isolated Rat Radial Artery

et al. 2009

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Abstract. The present study was designed to characterize the neurogenic contraction of rat radial artery. Electrical field stimulation (EFS) evoked frequency-dependent contraction that was abolished by tetrodotoxin (neuronal Na + channel blocker), guanethidine (sympathetic neuron blocker), or phentolamine (α-adrenoceptor blocker). The α 1 -adrenoceptor antagonist prazosin inhibited endothelium-independent contractions to EFS, noradrenaline (NA), and the α 1 -adrenoceptor agonist phenylephrine. Rauwolscine, an α 2 -adrenoceptor antagonist, augmented nerve-mediated contractions and reduced sensitivity to NA and the α 2 -adrenoceptor agonist BHT-920. The β-adrenoceptor antagonist propranolol diminished EFS-elicited contractions, while sensitivity to NA was enhanced by propranolol. Relaxations evoked by isoproterenol, a β-adrenoceptor agonist, were abolished by propranolol. N G -Nitro-L-arginine (L-NOARG), a nitric oxide (NO) synthase inhibitor, increased both nerve-mediated and NA-induced responses in endothelium-intact, but not in endothelium-denuded arteries. Moreover, endothelium-dependent responses to BHT-920 and isoproterenol were modified by L-NOARG. Tetraethylammonium (TEA) or 4-amynopyridine, the Ca 2+ -activated (K Ca ) or voltage-dependent K + (K V ) channel blockers, respectively, enhanced the neurogenic contractions observed. TEA but not 4-amynopyridine increased NA-induced contractions. The ATP-sensitive K + (K ATP )-channel blocker glibenclamide failed to modify adrenergic contractions. Blockade of capsaicin-sensitive primary afferents increased EFS-induced contractions. In conclusion, adrenergic contractions are predominantly mediated by muscular α 1 -adrenoceptors, while endothelial α 2 -and β-adrenoceptors play a minor role. Presynaptic α 2 -and β-adrenoceptors cannot be precluded. Noradrenergic neurotransmission in rat radial artery seems to be modulated by both stimulation of endothelial NO, K Ca , and K V channels and sensory C-fiber activation.

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Section: +mentioning

confidence: 99%

Modulation of Noradrenergic Neurotransmission in Isolated Rat Radial Artery

et al. 2009

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“…ITA grafts promote a greater release of nitric oxide than radial artery (RA) and saphenous vein (SF) grafts [13]. This makes the ITA a 'live graft' capable of dilation (adaptation of the caliber) and consequent increase in the blood flow, responding to the demand of the coronary territory and the area of the myocardium supplied.…”

Section: Discussionmentioning

confidence: 99%

<![CDATA[<B>Sequential histomorphometric study of the left internal thoracic artery</B>]]>

Kneubil¹,

Gomes²,

Aquino³

et al. 2006

Braz. j. cardiovasc. surg.

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Objective: The use of left internal thoracic artery (LITA) in coronary artery bypass surgery is currently recognized as the best option, providing lower incidences of cardiovascular events and superior long-term survival. Now, incremental utilization of these grafts makes a reassessment of its histological structure necessary. Therefore, the purpose of this study was to examine and compare the sequential histological structure of LITA.Method: Specimens of LITA harvested from 18 cadavers, divided into nine proportional segments, were studied. Cuts of each segment were stained by the Verhoeff-Van Gieson technique. The following parameters were analyzed: perimeter of the arterial lumen, thickness of the intima, thickness of the media layer, amount of elastic fiber in the media layer and the elastic fiber density.Results: The collected data showed that perimeter of the LITA decreases downstream on its course, the thickness of the intima is increased in the proximal segments, the thickness of the media layer diminishes throughout its extension, the number of elastic fibers is concentrated in the intermediate segments and the density of elastic fibers is reduced in the proximal and distal segments. Conclusion:Therefore, the findings of the present study validate the heterogeneity of the LITA sequential histological structure. Descriptors

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“…A previous study reported that the lower capacity of nitric oxide release may contribute to the susceptibility of RA to the vasospasm and may have an impact on the long-term patency [56].…”

Section: Cabg Using Radial Artery Graftmentioning

confidence: 99%

The Choice of Graft Conduits in Coronary Artery Bypass Grafting

Murashita¹

2017

Coronary Artery Bypass Graft Surgery

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The use of the left internal mammary artery (IMA) has been shown to improve longterm survival and has been a gold standard in coronary artery bypass grafting (CABG). However, the choice of second or third graft conduit is still controversial. Multiple studies demonstrated the beneit of using multiple arterial grafts such as right IMA and radial artery in addition to left IMA in terms of long-term survival and graft patency. However, most of the centers still perform CABG with one IMA and vein grafts in a real world. The challenges for bilateral IMA utilization include longer operative time and concerns for higher rates of perioperative morbidity and mortality associated with increased sternal wound infection. Several studies reported that skeletonization technique can reduce the risk of sternal wound infection. Radial artery is another arterial conduit, which does not increase the risk of sternal wound infection and is easy to harvest. The superiority between radial artery and right IMA has been controversial. In the meantime, multiple trials have been made to improve the patency of vein grafts. The choice of graft conduits in CABG should be well considered preoperatively based on each patient's backgrounds.

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Comparison of Nitric Oxide Release and Endothelium-Derived Hyperpolarizing Factor–Mediated Hyperpolarization Between Human Radial and Internal Mammary Arteries

Cited by 123 publications

References 24 publications

Modulation of Noradrenergic Neurotransmission in Isolated Rat Radial Artery

Modulation of Noradrenergic Neurotransmission in Isolated Rat Radial Artery

<![CDATA[<B>Sequential histomorphometric study of the left internal thoracic artery</B>]]>

The Choice of Graft Conduits in Coronary Artery Bypass Grafting

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