Comparison of new prognostic systems for patients with resectable hepatocellular carcinoma: Albumin‐Bilirubin grade and Albumin‐Indocyanine Green Evaluation grade

Honmyo, Naruhiko; Kobayashi, Tsuyoshi; Hamaoka, Michinori; Kohashi, Toshihiko; Abe, Tomoyuki; Oishi, Koichi; Tazawa, Hirofumi; Imaoka, Yasuhiro; Akita, Tomoyuki; Tanaka, Junko; Ohdan, Hideki

doi:10.1111/hepr.13393

Cited by 8 publications

(4 citation statements)

References 26 publications

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“…Invasive surgery, such as intraoperative and postoperative bleeding and longer operation time was also well-established risk factors for high morbidity and poor survival among patients with colorectal liver metastases and hepatocellular carcinoma [ 21 – 25 ]. ALBI score was well-known as a predictive factor of posthepatectomy liver failure and poor outcomes [ 26 , 27 ]. In our study, ALBI score had no relation with surgery-related DIC and high CCI.…”

Section: Discussionmentioning

confidence: 99%

Surgery-related disseminated intravascular coagulation predicts postoperative complications

et al. 2023

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Purpose The rate of postoperative morbidity, including infectious complications, is still high after major hepatobiliary pancreatic (HBP) surgery. Although surgery-related disseminated intravascular coagulation (DIC) occurs in some cases, its significance has not been elucidated in HBP surgery. This study aimed to evaluate the influence of surgery-related DIC on the complication severity after HBP surgery. Methods We analyzed the records of 100 patients with hepatectomy in two or more segments, hepatectomy with biliary tract reconstruction, and pancreaticoduodenectomy. The baseline characteristics and complications were compared between patients with and without surgery-related DIC on postoperative day 1 (POD1) after HBP surgery between 2010 and 2018. Complication severity was assessed using the Comprehensive Complication Index (CCI). Results The DIC group (surgery-related DIC on POD1) had predictive factors, such as larger bleeding volume and higher liver enzyme levels. The DIC group exhibited significantly elevated rates of surgical site infection, sepsis, prolonged intensive care unit stay, more frequent blood transfusions, and higher CCI. Furthermore, compared with and without adjustment of DIC, odds ratio (OR) of AST level and operation time for the risk of high CCI decreased (OR of AST level: 1.25 to 1.19 and OR of operation time: 1.30 to 1.23) and the significant differences had vanished. Conclusions Surgery-related DIC on POD1 could be a partial mediator between AST level, operation time and higher CCI. The prevention or proper management of surgery-related DIC on POD1 can be an important target to reduce the severity of postoperative complications.

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Section: Discussionmentioning

confidence: 99%

Surgery-related disseminated intravascular coagulation predicts postoperative complications

et al. 2023

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“…Recently, tumor-associated variables and liver function have been strongly related to longterm prognosis. Honmyo et al [10] reported that the albumin-bilirubin grade and albumin-indocyanine green evaluation grade were not only independent prognostic factors but also associated with postoperative complications. Preoperative nutritional status and immunological status were associated with postoperative complications and outcomes of patients with HCC such as obesity, Glasgow Prognostic Score (GPS) score, and neutrophil-to-lymphocyte ratio (NLR) [11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Impact of low skeletal muscle mass index and perioperative blood transfusion on the prognosis for HCC following curative resection

et al. 2020

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Background This study aimed to assess the prognostic factors including low skeletal muscle mass index (SMI) and perioperative blood transfusion for patients with hepatocellular carcinoma (HCC) following curative surgery. Methods This study included 139 patients with HCC who underwent hepatectomy between 2005 and 2016. Univariate and multivariate analyses were performed to identify variables associated with overall survival (OS) and recurrence-free survival (RFS). Results Low SMI was significantly related with poor OS, while blood transfusion had a strong impact on RFS. The male ratio and body mass index in the low SMI group were significantly higher than those in the high SMI group. There were no significant differences in age, virus etiology, laboratory data, liver function, tumor makers, and operative variables between the groups. Tumor factors such as tumor diameter, tumor number, poor differentiation, and intrahepatic metastasis (IM) did not significantly differ between the two groups. Operation time, intraoperative blood loss volume, and recurrence ratio were significantly higher in the blood transfusion group than in the non-transfusion group. IM was associated with poor OS and RFS. Conclusions Low SMI and blood transfusion were independently related with long-term prognosis in patients with HCC following curative surgery.

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“…That is, it includes several subjective items (ascites and encephalopathy) and interrelated items (ascites and serum albumin) [12]. After the introduction of the ALBI grading system, the good predictability of the ALBI grading system was confirmed in LC patients, irrespective of liver disease etiologies or the presence of hepatocellular carcinoma (HCC) in numerous clinical studies [13,14,15,16,17,18,19,20,21,22]. However, to our knowledge, the relationship between ALBI grade and npRQ in chronic liver disease (CLD) patients is largely unknown.…”

Section: Introductionmentioning

confidence: 99%

Association between Albumin-Bilirubin Grade and Non-Protein Respiratory Quotient in Patients with Chronic Liver Diseases

Takata

Nishikawa

Enomoto

et al. 2019

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We sought to elucidate the relationship between albumin-bilirubin (ALBI) grade and non-protein respiratory quotient (npRQ) calculated by indirect calorimetry in chronic liver disease (CLD) patients (n = 601, median age = 63 years). Factors linked to npRQ < 0.85, which is reported to be an optimal cutoff point for the prognosis in liver cirrhosis (LC) patients, were also investigated using univariate and multivariate analyses. The median npRQ for all cases was 0.86. In total, 253 patients (42.1%) had npRQ < 0.85. The proportions of patients with npRQ < 0.85 in LC and non-LC patients were 51.9% (166/320) in LC patients and 31.0% (87/281) in non-LC patients (p < 0.0001). The median npRQ in ALBI grades 1, 2, and 3 for all cases were: 0.89, 0.85, and 0.82 (overall p < 0.0001). The proportions of patients with npRQ < 0.85 were 31.0% (71/229) in ALBI grade 1, 46.34% (152/328) in ALBI grade 2, and 68.18% (30/44) in ALBI grade 3 (overall p < 0.0001). In multivariate analyses of factors linked to npRQ < 0.85, ALBI grade 3 (p = 0.0095, hazard ratio = 3.242, ALBI grade 1 as a reference) was an independent predictor along with prothrombin time (p = 0.0139). In conclusion, ALBI grade can be a useful marker for npRQ in patients with CLDs.

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Comparison of new prognostic systems for patients with resectable hepatocellular carcinoma: Albumin‐Bilirubin grade and Albumin‐Indocyanine Green Evaluation grade

Cited by 8 publications

References 26 publications

Surgery-related disseminated intravascular coagulation predicts postoperative complications

Surgery-related disseminated intravascular coagulation predicts postoperative complications

Impact of low skeletal muscle mass index and perioperative blood transfusion on the prognosis for HCC following curative resection

Association between Albumin-Bilirubin Grade and Non-Protein Respiratory Quotient in Patients with Chronic Liver Diseases

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