Comparison of Neutrophilia Induced by Leukocytic Endogenous Mediator and by Cobra Venom Factor

Mitchell, Roger H.; McClelland, Ruth; Kampschmidt, Ralph F.

doi:10.3181/00379727-169-41349

Cited by 6 publications

(6 citation statements)

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“…There is some evidence that supports this hypothesis. Mitchell et al [1982] found similar neutro phil depletions from the bone marrow 1 h after injection of interleukin I and cobra ve nom factor (CoF). However, at this time the number of circulating neutrophils after CoF was almost twice the number of neutrophils circulating after interleukin 1 (19,186 ± 999/mm3 vs. 10.305 ± 3,177).…”

Section: Effects Of Interleukin Imentioning

confidence: 53%

“…Sim ilar kinetics, but not as marked changes, were found after intravenous injections of super natants from sterile peritoneal exudates. Kampschmidl et al [1972] documented a sig nificant neutropenia 30 min after intraperitoneal injections of interleukin I (endogenous pyrogen from peritoneal leukocytes), which was followed by a neutrophilia at 1 h. The mechanism of postinterleukin I neutropenia is not known and its existence is somewhat questionable, since neutropenia was not ob served by Mitchell et al [1982] following injection of partially purified interleukin 1 (leukocytics endogenous mediator from peri toneal exudate leukocytes) into rats. Neutro penia could have been caused by endotoxin contamination, since after injection of low doses of endotoxin a transient neutropenia, followed by a quick recovery and neutro philia has been observed.…”

Section: Effects Of Interleukin Imentioning

confidence: 99%

“…most likely the marginal pool. Yet the difference between neutrophil levels after CoF and interleukin I measured by Mitchell et al [ 1982] exceeded the size of the marginal pool which was found to be approximately equal to the normal circulating pool [Athens et al, 1961a], by a factor greater than 5 (nor mal circulating neutrophil level in the rat was 1,'400-1,800/mm3). Thus, it is much more likely that the size of the marginal pool in creased during neutrophilia produced by in terleukin I injection and did not increase, or increased by a much lesser degree during CoF-induced neutrophilia.…”

Section: Effects Of Interleukin Imentioning

confidence: 99%

“…Mitchell et al [1982] compared neutrophil kinetics after in vivo and in vitro activation of complement with CoF in the rat. A transient neutropenia was followed by a neutrophilia in both cases, with neutro philia after in vitro complement activation, beginning 5-10 min after injection and 15-20 min.…”

Section: Effects Of Complement-derived Factorsmentioning

confidence: 99%

See 3 more Smart Citations

Application of <sup>51</sup>Cr-Labelled PMN Leukocytes in Quantitating PMN Kinetics in Systemic and Local Inflammatory Mediated Processes

Cybulsky¹,

Movat²

1983

Pathol Immunopathol Res

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Section: Effects Of Interleukin Imentioning

confidence: 53%

Section: Effects Of Interleukin Imentioning

confidence: 99%

Section: Effects Of Interleukin Imentioning

confidence: 99%

Section: Effects Of Complement-derived Factorsmentioning

confidence: 99%

See 2 more Smart Citations

Application of <sup>51</sup>Cr-Labelled PMN Leukocytes in Quantitating PMN Kinetics in Systemic and Local Inflammatory Mediated Processes

Cybulsky¹,

Movat²

1983

Pathol Immunopathol Res

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“…The increase in peripheral blood neutrophils after injections of EP seems to be due to the more rapid release of neutrophils from the bone marrow without alteration of the marginal neutrophil pool (17). The site of action would logically be the bone marrow, and so far no intermediate has been identified (25). Apparently, the rabbit pl 5 EP is destroyed before it reaches this site, or the proper receptors are not present for this molecule in the rat.…”

Section: Resultsmentioning

confidence: 99%

Further comparisons of endogenous pyrogens and leukocytic endogenous mediators

Kampschmidt¹,

Upchurch²,

Worthington³

1983

Infect Immun

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It was recently shown (Murphy et al., Infect. Immun. 34:177-183), that rabbit macrophages produce two biochemically and immunologically distinct endogenous pyrogens. One of these has or copurifies with substances having a molecular weight of 13,000 and a pI of 7.3. This protein was produced by blood monocytes or inflammatory cells elicited in 16-h rabbit peritoneal exudates. These acute peritoneal exudates were produced by the intraperitoneal injection of large volumes of saline containing shellfish glycogen. When the leukocytes in these exudates were washed and incubated at 37 degrees C in saline, they released an endogenous pyrogen. The injection of this pyrogen into rabbits, rats, or mice caused the biological manifestations which have been attributed to leukocytic endogenous mediator. These effects were increases in blood neutrophils, the lowering of plasma iron and zinc levels, and the increased synthesis of the acute-phase proteins. The other rabbit endogenous pyrogen seems to be a family of proteins with isoelectric points between 4.5 and 5.0. These proteins are produced by macrophages in the lung, liver, or in chronic peritoneal exudates. In these experiments, the lower-isoelectric-point endogenous pyrogens were produced by macrophages from the peritoneal cavity of rabbits that had been injected 4 days earlier with 50 ml of light mineral oil. These rabbit pyrogens were found to have leukocytic endogenous mediator activity in mice but to be completely inactive in rats. When injected into rabbits, these proteins produced fever, lowered plasma iron, increased blood neutrophils, but failed to elevate plasma fibrinogen.

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The Numerous Postulated Biological Manifestations of Interleukin-1

Kampschmidt

1984

Journal of Leukocyte Biology

140

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Over the past 25 years there has been an ever‐expanding interest in the mediators that control the immune response [98,133], One of these is produced by macrophages and was first called “lymphocyte activating factor” [49–51] but is now designated “interleukin‐1” (IL‐1) [118]. As the physical characteristics of IL‐1 began to be described, it was noted that they were similar to those of endogenous pyrogen (EP) [128] [151] and leukocytic endogenous mediator (LEM) [85]. Since then, many of the biochemical changes that occur in the host during infection, inflammation, or neoplasia have been attributed to this unique family of monokines. In this review, the family of monokines that has similar physical and biological properties will be referred to as EP/LEM/IL‐1. When only one biological activity was measured, the designation will be for that activity. It will be the purpose of this review to examine the evidence that suggests that EP/ LEM/IL‐1 has numerous biological activites and to describe its chemical and biological properties, species specificity, and possible sites of action. Finally, I will attempt to address the issue of why there might be a closely related group of mediators with such a broad range of biological activities.

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Comparison of Neutrophilia Induced by Leukocytic Endogenous Mediator and by Cobra Venom Factor

Cited by 6 publications

References 0 publications

Application of <sup>51</sup>Cr-Labelled PMN Leukocytes in Quantitating PMN Kinetics in Systemic and Local Inflammatory Mediated Processes

Application of <sup>51</sup>Cr-Labelled PMN Leukocytes in Quantitating PMN Kinetics in Systemic and Local Inflammatory Mediated Processes

Further comparisons of endogenous pyrogens and leukocytic endogenous mediators

The Numerous Postulated Biological Manifestations of Interleukin-1

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