Comparison of neurocognitive function in major depressive disorder, bipolar disorder, and schizophrenia in later life: A cross-sectional study of euthymic or remitted, non-demented patients using the Japanese version of the Brief Assessment of Cognition in Schizophrenia (BACS-J)

Terachi, Sayaka; Yamada, Takeshi; Pu, Shenghong; Yokoyama, Katsutoshi; Matsumura, Hiroshi; Kaneko, Koichi

doi:10.1016/j.psychres.2017.04.058

Cited by 35 publications

(35 citation statements)

References 32 publications

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“…The magnitude of cognitive dysfunction was compatible to which reported in a previous study (using BACS to assess cognitive function among MDD patients, Fig. 1A) (Terachi et al., 2017). We also compared our results with previous studies with bipolar disorder and schizophrenia patients conducting BACS tests (Fig.…”

Section: Discussionsupporting

confidence: 90%

“…1B). Similar degrees of cognitive impairments were observed in patients with bipolar disorder and schizophrenia patients, while patients with MDD may exhibited smaller impairments in several neurocognitive domains compared to patients with either of the other two disorders (Terachi et al., 2017).…”

Section: Discussionmentioning

confidence: 66%

“…(A) Comparison of performance of each BACS subtest in patients with depressive disorder (Compared to Terachi et al. (2017)).…”

Section: Discussionmentioning

confidence: 99%

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Defining cognitive profiles of depressive patients using the Brief Assessment of Cognition in Affective Disorders

Chen

Lee

et al. 2019

PeerJ

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Background Cognitive impairments in patients with depressive disorders have a negative impact on their daily skill functioning and quality of life. In this study, we evaluated the cognitive profiles and associated factors of patients with depressive disorders with the Brief Assessment of Cognition in Affective Disorders (BAC-A). Methods This cross-sectional study consisted of 75 patients with depressive disorders (56 patients with major depressive disorder (MDD) and 19 patients with depressive disorder NOS or dysthymic disorder (non-MDD)). We evaluated the participants’ cognitive functions at euthymic status using the BAC-A. The BAC-A includes six subtests derived from the Brief Assessment of Cognition in Schizophrenia (BAC-S) and Affective Processing Tests. The current severity of depressive symptoms was assessed with the 17-item Hamilton Depression Rating Scale (HAMD-17), and we recorded any psychotropic drugs being used by the patients. Results We observed no differences in cognitive profiles in the MDD group and non-MDD group after adjusting for educational levels, severity of depression, and psychotropic drugs. Instead, the HAMD-17 scores were negatively correlated to cognitive performance in working memory, motor speed, verbal fluency, attention and processing speed, executive function, composite score, and the six indexes of the Affective Processing Test measured by the BAC-A. A longer illness duration was associated with worse performance of four indexes of the Affective Processing Test. Furthermore, benzodiazepine use was associated with a worse performance of verbal memory, and antidepressant use was associated with better motor speed performance. Conclusion The current severity of depressive symptoms and psychotropic drugs being taken, not the diagnosis category, are associated with cognitive impairments in patients with depressive disorders. Clinicians should pay particular attention to managing residual depressive symptoms and prescribing adequate psychotropic drugs in order to eliminate depressive patients’ cognitive deficits.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 66%

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Defining cognitive profiles of depressive patients using the Brief Assessment of Cognition in Affective Disorders

Chen

Lee

et al. 2019

PeerJ

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“…Differences of node strength centrality between FES-related and MDD-related cognitive functions included general intelligence, motor speeding, perceptual sensitivity, visual and pattern recognition memory, shifting, planning, sustained attention and inhibition, working memory, and strategy. Consistent with previous studies, patients with FES had more impairments in premorbid IQ, memory, attention, processing speed, and learning than patients with MDD [22][23][24]. Neuroimaging studies have demonstrated that patients with schizophrenia have more severe deficits in prefrontal and superior temporal activation during the performance of working memory tasks [25,26].…”

Section: Discussionsupporting

confidence: 84%

Neurocognitive Graphs of First-Episode Schizophrenia and Major Depression Based on Cognitive Features

et al. 2017

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Neurocognitive deficits are frequently observed in patients with schizophrenia and major depressive disorder (MDD). The relations between cognitive features may be represented by neurocognitive graphs based on cognitive features, modeled as Gaussian Markov random fields. However, it is unclear whether it is possible to differentiate between phenotypic patterns associated with the differential diagnosis of schizophrenia and depression using this neurocognitive graph approach. In this study, we enrolled 215 first-episode patients with schizophrenia (FES), 125 with MDD, and 237 demographically-matched healthy controls (HCs). The cognitive performance of all participants was evaluated using a battery of neurocognitive tests. The graphical LASSO model was trained with a one-vs-one scenario to learn the conditional independent structure of neurocognitive features of each group. Participants in the holdout dataset were classified into different groups with the highest likelihood. A partial correlation matrix was transformed from the graphical model to further explore the neurocognitive graph for each group. The classification approach identified the diagnostic class for individuals with an average accuracy of 73.41% for FES vs HC, 67.07% for MDD vs HC, and 59.48% for FES vs MDD. Both of the neurocognitive graphs for FES and MDD had more connections and higher node centrality than those for HC. The neurocognitive graph for FES was less sparse and had more connections than that for MDD. Thus, neurocognitive graphs based on cognitive features are promising for describing endophenotypes that may discriminate schizophrenia from depression.

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“…It consists of various tests that assess the following six cognitive domains: verbal memory, working memory, motor speed, verbal fluency, attention and speed of information processing, and executive function. The BACS was originally developed for patients with schizophrenia, but has also been used for those with bipolar disorder 34 , 35 , and recently for those with MDD 36 , 37 . Importantly, the use of this comprehensive battery consisting of highly reliable and valid tests that were selected specifically for their tolerability in patients with various psychiatric disorders, will facilitate comparisons across numerous studies.…”

Section: Introductionmentioning

confidence: 99%

Association between cognitive deficits and suicidal ideation in patients with major depressive disorder

Setoyama

Noda

2017

Sci Rep

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The role of cognitive function in suicidal ideation in patients with major depressive disorder (MDD) has not been adequately explored. This research sought to measure the relationship between suicidal ideation and cognitive function. Therefore, in this study, the association between cognitive function and suicidal ideation in patients with MDD was assessed. Cognitive function was evaluated in 233 patients with MDD using the Japanese version of the Brief Assessment of Cognition in Schizophrenia (BACS). Suicidal ideation was assessed using item 3 of the Hamilton Depression Rating Scale. Approximately 59.2% of the patients (138/233) expressed suicidal ideation. Among the BACS subtests, only the executive function scores were significantly lower in patients with MDD with than in those without (p < 0.005). In addition, the executive function, motor speed function, and composite scores correlated negatively with the severity of suicidal ideation in these patients. These results suggest that executive function, motor speed function, and global neuropsychological function are associated with suicidal ideation in patients with MDD and that the BACS neuropsychological battery is an efficient instrument for monitoring these characteristics. Moreover, specific BACS scores can potentially serve as cognitive biomarkers of suicide risk in patients with MDD.

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Comparison of neurocognitive function in major depressive disorder, bipolar disorder, and schizophrenia in later life: A cross-sectional study of euthymic or remitted, non-demented patients using the Japanese version of the Brief Assessment of Cognition in Schizophrenia (BACS-J)

Cited by 35 publications

References 32 publications

Defining cognitive profiles of depressive patients using the Brief Assessment of Cognition in Affective Disorders

Defining cognitive profiles of depressive patients using the Brief Assessment of Cognition in Affective Disorders

Neurocognitive Graphs of First-Episode Schizophrenia and Major Depression Based on Cognitive Features

Association between cognitive deficits and suicidal ideation in patients with major depressive disorder

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