Comparison of nebulized ketamine with nebulized magnesium sulfate on the incidence of postoperative sore throat

Sivalingam, Sivakumar; Bacthavasalame, Arish T; Venkatesh, Ranjan R; Zachariah, Mamie; George, Sagiev Koshy; Ravichandran, K.

doi:10.4103/aer.aer_148_18

Cited by 18 publications

(13 citation statements)

References 21 publications

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“…Patients with general anesthesia require endotracheal intubation to facilitate airway management during anesthesia and prevent foreign bodies from entering the airway [ 1 ]. Endotracheal intubation during general anesthesia, postoperative extubation, and poor physical activity during surgery damage patients' airway mucosa and cause postoperative sore throat (POST) [ 2 ]. The main clinical manifestations of POST are redness, swelling and congestion in the throat, varying degrees of pain, hoarseness, and foreign body sensation in the throat [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Traditional Chinese Medicine Compounds Containing Lonicera japonica, Chrysanthemum morifolium, and Siraitia grosvenorii Inhibits the Growth of Streptococcus mutans

Zhou

Reheman

Kang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Postoperative sore throat (POST) is one of the common complications after endotracheal intubation under general anesthesia. This work attempted to design and screen out the traditional Chinese medicine (TCM) compounds containing Lonicera japonica Thunb., Chrysanthemum morifolium Ramat., and Siraitia grosvenorii (Swingle) C. Jeffrey ex A. M. Lu et Z. Y. Zhang, and further explored its antibacterial effect on POST. The antibacterial activities of Lonicera japonica, Chrysanthemum morifolium, and Siraitia grosvenorii on Streptococcus mutans (S. mutans) UA159 was measured. Lonicera japonica (40 mg/mL), Chrysanthemum morifolium (10 mg/mL), and Siraitia grosvenorii (10 mg/mL) effectively inhibited the growth of S. mutans. Then, 5 different TCM compounds were designed using the U5 (53) uniform design experimentation method. TCM compound C3 (50 mg/mL Lonicera japonica, 10 mg/mL Chrysanthemum morifolium, and 15 mg/mL Siraitia grosvenorii) significantly promoted the inhibition zone and inhibited the biofilm formation of S. mutans. In addition, TCM compound C3 exerted great antibacterial effects on S. mutans and had the least effect on cell viability of primary human pharyngeal epithelial cells. In conclusion, this work demonstrated that TCM compound containing Lonicera japonica, Chrysanthemum morifolium, and Siraitia grosvenorii inhibited the growth of S. mutans. Thus, this study provides a theoretical basis for screening out the optimal compatibility of effective components in TCM mouthwash for relieving POST.

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Section: Introductionmentioning

confidence: 99%

Traditional Chinese Medicine Compounds Containing Lonicera japonica, Chrysanthemum morifolium, and Siraitia grosvenorii Inhibits the Growth of Streptococcus mutans

Zhou

Reheman

Kang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…POST commonly occurs after endotracheal intubation and is regarded as most common complication with incidence varying from 21% to 65%. 1,2 Various pharmacological and non-pharmacological measures have been taken as it can lead to patient discomfort in the recovery period. Non-pharmacological measures such as smaller size endotracheal tubes, smooth laryngoscopy and intubation, and designed cuff with optimum pressure were used previously.…”

Section: Introductionmentioning

confidence: 99%

Comparison of intravenous route versus nebulization of magnesium sulfate (MgSO4) for post-operative sore throat and hoarseness: A randomized comparative double-blinded clinical trial

2022

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Background: Multiple drugs in different routes have been studied for the treatment of post-operative sore throat (POST). We are studying effect of magnesium sulfate on POST in two different routes. Aims and Objectives: This study aims to compare the efficacy of nebulization versus intravenous (IV) magnesium sulfate in reducing incidence of POST and hoarseness of voice. Materials and Methods: This prospective randomized double-blind study was done on 150 patients undergoing unilateral percutaneous nephrolithotomy (PCNL) surgeries under general anesthesia. Patients were randomly allocated into Group N (n=75) and Group I (n=75). Group N received 10 mg/kg MgSO4 in 5 mL of normal saline as nebulization 20 min before induction and 100 mL normal saline IV over 20 min post-induction. Group I received 5 mL of normal saline as nebulization pre-induction and 10 mg/kg MgSO4 in 100 mL saline IV over 20 min post-induction. Postoperatively, visual analog scale (VAS) score was used for the assessment of sore throat at rest and dynamic VAS (DyVAS) for pain during swallowing at the 0, 1st, 6th, 12th, and 24th h. Post-operative hoarseness graded on 4-point score was also assessed. Results: Incidence of POST in Group N was 29.17% compared to 52.86% in Group I at 0 h which was lower and statistically significant and results were alike at the 1st and 6th h. The VAS at rest and DyVAS were lower and statistically significant in Group N compared to Group I at the 0, 1st, and 6th h. Conclusion: Incidence of POST was significantly less with nebulized route of magnesium sulfate compared to IV route of magnesium sulfate.

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“…The primary cause of post-operative sore throat is airway irritation and inflammation or trauma caused by an endotracheal tube; however, the airway may be highly sensitive due to a preexisting comorbid condition. 1 In 30% to 70% of patients undergoing endotracheal intubation, post operative sore throat and hoarseness are comm-only seen soon after extubation. 1 This leads to an increase in morbidity and causes further complications in patients.…”

Section: Introductionmentioning

confidence: 99%

“…1 In 30% to 70% of patients undergoing endotracheal intubation, post operative sore throat and hoarseness are comm-only seen soon after extubation. 1 This leads to an increase in morbidity and causes further complications in patients. Several techniques have been practised to decrease the incidence of post-operative sore throat after extubation.…”

Section: Introductionmentioning

confidence: 99%

“…WHO sample size calculator version 1.0 was used to calculate the sample size by keeping the level of significance (α) 5%, power of the test 90 % (1-β), anticipated population proportion-1 (p1) as 55% and anticipated population proportion-2 (p2) as 32%. 1 The calculated sample size of the study was 154. Using the Lottery method, patients were allocated to two Groups equally (Group-A and Group-B) 77 in each Group through consecutive non-probability sampling.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Nebulized Ketamine with Nebulized Magnesium Sulfate for the Prevention of Postoperative Sore Throat

Ranjha

Saeed

Shah

et al. 2022

PAFMJ

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Objective: To compare the effects of nebulized Ketamine versus nebulized Magnesium Sulfate to prevent post-operative sore throat. Study Design: Quasi-Experimental Study. Place and Duration of Study: Department of Anaesthesia, Combined Military Hospital, Rawalpindi Pakistan, from Sep 2020 to Feb 2021. Methodology: A total of 154 patients who underwent general anaesthesia for elective procedures were randomly included in the study. These patients were divided into two equal Groups, i.e., Group-A (n=77), who received Magnesium Sulphate 250mg in 5ml saline and Group-B (n=77), who received Ketamine 50mg in 5ml saline, respectively. The effects of nebulized Ketamine versus nebulized Magnesium Sulfate to prevent post-operative sore throat, were observed in both the Groups. Results: Both drugs were effective in the prevention of sore throat after extubation. Our study showed that Ketamine nebulization was more effective than Magnesium Sulfate nebulization in preventing sore throat. The frequency of sore throat in Group-A was 54.5% (42 out of 77 patients) as compared to 31.2% (24 out of 77 patients) in Group-B, which was statistically significant (p=0.003). Conclusion: Post-operative sore throat is more effectively controlled with Ketamine as compared to Magnesium Sulfate

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Comparison of nebulized ketamine with nebulized magnesium sulfate on the incidence of postoperative sore throat

Cited by 18 publications

References 21 publications

Traditional Chinese Medicine Compounds Containing Lonicera japonica, Chrysanthemum morifolium, and Siraitia grosvenorii Inhibits the Growth of Streptococcus mutans

Traditional Chinese Medicine Compounds Containing Lonicera japonica, Chrysanthemum morifolium, and Siraitia grosvenorii Inhibits the Growth of Streptococcus mutans

Comparison of intravenous route versus nebulization of magnesium sulfate (MgSO4) for post-operative sore throat and hoarseness: A randomized comparative double-blinded clinical trial

Comparison of Nebulized Ketamine with Nebulized Magnesium Sulfate for the Prevention of Postoperative Sore Throat

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