Comparison of Near-Infrared Spectroscopy and Tissue Po₂ Time Series in Patients after Severe Head Injury and Aneurysmal Subarachnoid Hemorrhage

Abstract

Monitoring of local oxygen pressure in brain white matter (tip(O2)) and of local hemoglobin oxygen saturation (rS(O2)) with near-infrared spectroscopy (NIRS) are increasingly employed techniques in neurosurgical intensive care units. Using frequency-based mathematical methods, the authors sought to ascertain whether both techniques contained similar information. Twelve patients treated in the intensive care unit were included (subarachnoid hemorrhage, n = 3; traumatic brain injury, n = 9). A tip(O2) probe and an NIRS sensor were positioned over the frontal lobe with the most pathologic changes on initial computed tomography scan. The authors calculated coherence of tip(O2) and rS(O2) ts overall density distribution, its distribution per data set, and its time evolution. The authors identified a band of significantly correlated frequencies (from 0 to 1.3 x 10(3) Hz) in more than 90% of the data sets for coherence and overall density distribution. Time evolution showed slow but marked changes of significant coherence. By means of spectral analysis the authors show that tip(O2) and rS(O2)signals contain similar information, albeit using completely different registration methodologies.

Monitoring and Detection of Vasospasm II: EEG and Invasive Monitoring

“…In 2002, Keller et al [49] described preliminary findings using NIRS to detect regional cerebral oxygenation in with SAH. A positive correlation for monitoring local oxygen pressure was noted using PtiO 2 analysis and local oxygen monitoring via NIRS technology in 12 patients (9 traumatic brain injury and 3 SAH) [50]. In another small study (N = 27), Zweifel et al [51] showed that NRIS could be used to detect regional cerebral oxygenation in SAH patients.…”

Relationship between post-operative cognitive dysfunction and regional cerebral oxygen saturation and β-amyloid protein

“…The rSO 2 was detected by NIRS (Brawanski et al, 2002) using a near-infrared light spectrum analyzer INVOS5100 (Somaneti, USA). The rSO 2 probe was placed on the right side of the forehead.…”

Use of near-infrared spectroscopy as a measure of cerebrovascular health in aging adults

“…NIRS is specifically a measure of regional cerebral tissue oxygenation saturation, primarily reflective of venous blood (Brawanski, Faltermeier, Rothoerl, & Woertgen, 2002;Ohmae et al, 2006) and is highly sensitive to conditions that alter the flow of oxygenated blood to brain tissue, including cerebral ischemia in subarachnoid hemorrhage, cerebral vasospasm in response to cardiac surgery, hyperperfusion after carotid endarerectomy, hypoperfusion related to anesthesia, as well as to changes in cerebral oxygenation related to high altitude, carbon dioxide challenge, and transient induced hypoxia in healthy volunteers (Hadolt & Litscher, 2003;Kim et al, 2000;McCormick, Stweart, Goetting, & Balakrishnan, 1991;. As noted earlier, older adults, even if they are free of cardiovascular disease, show declining baseline levels of oxygenated CBF relative to younger adults (Bangen et al, 2009;Larsson et al, 2001).…”