Comparison of near infrared and microwave resonance sensors for at-line moisture determination in powders and tablets

Corredor, Claudia C.; Bu, Dongsheng; Both, Douglas

doi:10.1016/j.aca.2011.03.048

Cited by 76 publications

(47 citation statements)

References 26 publications

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“…Compression problems such as capping can occur due to the presence of excessive fines within the particle size distribution [76,77]. Particle or granule moisture content can impact drug product stability, compressibility and tablet physical properties [78]. In addition, the physiochemical properties of the active ingredient could affect the propensity for form change due to temperature increase during the compaction process [79].…”

Section: Tablet Press (With Integrated Hopper and Feed Frame)mentioning

confidence: 99%

Modeling of Particulate Processes for the Continuous Manufacture of Solid-Based Pharmaceutical Dosage Forms

2013

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Abstract:The objective of this work is to present a review of computational tools and models for pharmaceutical processes, specifically those for the continuous manufacture of solid dosage forms. Relevant mathematical methods and simulation techniques are discussed, as is the development of process models for solids-handling unit operations. Continuous processing is of particular interest in the current study because it has the potential to improve the efficiency and robustness of pharmaceutical manufacturing processes.

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Section: Tablet Press (With Integrated Hopper and Feed Frame)mentioning

confidence: 99%

Modeling of Particulate Processes for the Continuous Manufacture of Solid-Based Pharmaceutical Dosage Forms

2013

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“…Pre-processing of spectral data allows for spectral correction by increasing the signal and minimizing undesired information including baseline drifts, scatter variation, path-length variation, and background noise. The most common pretreatment techniques (Table 1) used in pharmaceutical data processing include multiplicative scatter correction (MSC) (Virtanen et al, 2008;Lee et al, 2009;Cairos et al, 2009;Puchert et al 2010;Neves et al, 2010), standard normal variate (SNV) (Virtanen et al, 2008;Cairos et al, 2009;Cruz et al, 2011), and Savitzky-Golay filtering (Virtanen Palou et al (2012) et al , 2008;Cairos et al, 2009;Puchert et al, 2010;Gendre et al, 2011;Corredor et al, 2011;Cruz et al, 2011;Neves et al, 2012). Briefly, the purpose of MSC is to correct the scatter level of the spectra by elimination of the spectral difference of the data (Puchert et al, 2010).…”

Section: Mathematical Pretreatmentsmentioning

confidence: 99%

“…The PLS model developed for KF data (water content) and NIR spectra demonstrated a strong correlation with   of 0.99 and Root mean square error (RMSE) of 2.55% and 2.03%, respectively. Corredor et al (2011) developed a new approach for determining the moisture content in powders and tablet samples. In this work, they applied NIR (1000-2500 nm) and microwave resonance (MR) sensors for in-line moisture measurement of the samples, while the KF method was carried out for reference measurement of water content.…”

Section: Moisture Contentmentioning

confidence: 99%

Spectroscopic Techniques for Nondestructive Quality Inspection of Pharmaceutical Products: A Review

Kandpal

Park

Tewari

et al. 2015

Journal of Biosystems Engineering

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Spectroscopy is an emerging technology for the quality assessment of pharmaceutical samples, from tablet manufacturing to final quality assurance. The traditional methods for the quality management of pharmaceutical tablets are time consuming and destructive, while spectroscopic techniques allow rapid analysis in a non-destructive manner. The advantage of spectroscopy is that it collects both spatial and spectral information (called hyperspectral imaging), which is useful for the chemical imaging of pharmaceutical samples. These chemical images provide both qualitative and quantitative information on tablet samples. In the pharmaceutics, spectroscopic techniques are used for a variety of applications, such as analysis of the homogeneity of powder samples as well as determination of particle size, product composition, and the concentration, uniformity, and distribution of the active pharmaceutical ingredient in solid tablets. This review paper presents an introduction to the applications of various spectroscopic techniques such as hyperspectroscopy and vibrational spectroscopies (Raman spectroscopy, FT-NIR, and IR spectroscopy) for the quality and safety assessment of pharmaceutical solid dosage forms. In addition, various chemometric techniques that are highly essential for analyzing the spectroscopic data of pharmaceutical samples are also reviewed.

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“…NIR spectroscopy is now used to determine the water content in powders or granules [100][101][102], tablets or capsules [103][104][105], as well as in lyophilised vials or solutions [106]. Use of NIRS in moisture determination is long established, therefore most of the relevant applications for this purpose are now implemented on-line (Figure 9.14).…”

Section: Moisture Determinationmentioning

confidence: 99%

Near Infrared Spectroscopy in Drug Discovery and Development Processes

Roggo¹,

Dégardin²,

Ulmschneider³

2012

Physico-Chemical Methods in Drug Discovery and Development

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Comparison of near infrared and microwave resonance sensors for at-line moisture determination in powders and tablets

Cited by 76 publications

References 26 publications

Modeling of Particulate Processes for the Continuous Manufacture of Solid-Based Pharmaceutical Dosage Forms

Modeling of Particulate Processes for the Continuous Manufacture of Solid-Based Pharmaceutical Dosage Forms

Spectroscopic Techniques for Nondestructive Quality Inspection of Pharmaceutical Products: A Review

Near Infrared Spectroscopy in Drug Discovery and Development Processes

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