Comparison of nasal mucociliary clearance in adenoid hypertrophy with or without otitis media with effusion

Yazıcı, Haşmet; Soy, Fatih Kemal; Kulduk, Erkan; Doğan, Sedat; Dündar, Rıza; Sakarya, Engin Umut; Can, İlknur

doi:10.1016/j.ijporl.2014.04.037

Cited by 21 publications

(16 citation statements)

References 15 publications

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“…Our results are consistent with a previously published study, in which impaired nasal MCT in AH grade 2 and grade 3 was found to be significantly improved after adenoidectomy. MCT was shorter in patients with AH grade 2 compared with grade 3; however, there was no correlation between adenoid size and MCT improvement …”

Section: Discussionmentioning

confidence: 73%

“…Our findings suggest that pediatric patients with AH have an acquired, temporary disorder of CBF, which is improved after adenoidectomy to the level of healthy children. Increased nasal CBF after surgery could explain the postoperative improvement of nasal MCV and MCT recorded in previous studies . We suppose that acquired (secondary) ciliary dyskinesia, observed in children with AH, could contribute to the pathogenesis of RRI in these patients by negatively affecting mucociliary clearance and creating a local environment that promotes further development of infection.…”

Section: Discussionmentioning

confidence: 73%

“…Its efficiency is affected by the viscoelastic properties of mucus as well as by the coordinated movement of respiratory cilia—particularly their beating pattern and frequency . In previous studies, reduced nasal mucociliary clearance velocity (MCV) and higher nasal MCT were observed in children with AH using the saccharine test, while 1 month and 6 months after adenoidectomy, these parameters were significantly improved and reached the values of healthy children …”

Section: Discussionmentioning

confidence: 97%

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Ciliary beat frequency in children with adenoid hypertrophy

Marusiakova

Ďurdík

Jeseňák

et al. 2020

Pediatric Pulmonology

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Background Children with adenoid hypertrophy (AH) have impaired respiratory system defense mechanisms, such as mucociliary clearance. We hypothesized that AH negatively affects one of the most important aspects of mucociliary clearance—ciliary beat frequency (CBF) and that adenoidectomy could potentially restore this essential defence mechanism of the airways. This study evaluated the influence of AH and endoscopic adenoidectomy on the CBF of the nasal respiratory epithelium in children. Methods This prospective study included 64 children with confirmed AH aged 3 to 18 years and 43 age‐ and sex‐matched healthy controls. Nasal CBF was analyzed using a digital high‐speed video microscope and the software application Ciliary Analysis (NI LabVIEW). The preoperative adenoid size was assessed according to Cassano. Clinical symptoms of chronic rhinosinusitis were evaluated using the SNOT‐20 questionnaire. Results Children with AH had a median CBF of 5.35 ± 1.06 Hz. Six months after surgery, the median CBF was significantly higher (6.48 ± 0.88 Hz; P < .001) and reached the values of healthy children (6.37 ± 0.71 Hz; P = .512). The size of the adenoid tissue did not correlate with the CBF. No influence of age or gender on the CBF was found. After adenoidectomy, a significant reduction of the mean total SNOT‐20 score was recorded (P < .01). Conclusion Children with clinically symptomatic AH have impaired mucociliary clearance due to decreased nasal CBF. Removal of hypertrophic adenoid tissue normalizes the CBF and reduces the presence of clinical symptoms of rhinosinusitis.

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Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 97%

See 1 more Smart Citation

Ciliary beat frequency in children with adenoid hypertrophy

Marusiakova

Ďurdík

Jeseňák

et al. 2020

Pediatric Pulmonology

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“…Effective MCC requires appropriate mucus production, coordinated ciliary activity, and the mucus-cilia interaction. Cilia line the nasopharynx, middle ear, paranasal sinuses, and tracheobronchial airways; therefore, any disturbance in MCC leads to the stagnation of secretions and recurrent middle ear, sinonasal, and lower respiratory tract infections (5,(9)(10)(11) . There are two main causes of MCC impairment: impaired ciliary function or mucus structure and movement (12,13) .…”

Section: Discussionmentioning

confidence: 99%

Nasal mucociliary clearance in chronic renal failure: comparision of pre-dialysis and dialysis stages

Uluyol¹,

Alp²,

Kılıçaslan³

et al. 2016

Terh

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Objective: Chronic renal failure (CRF) is an irreversible condition that has many otorhinolaryngological manifestations. In this study we aimed to investigate the effects of CRF and haemodialysis treatment on nasal mucociliary clearance (MCC) and to explain the possible pathophysiological mechanisms. Methods: This study included 27 patients with end-stage CRF who were not undergoing haemodialysis (pre-dialysis group), 36 patients with CRF on haemodialysis (dialysis group), and 36 heathy individuals. Nasalmucociliary clearance was measured using the saccharin clearance test (SCT) and the results were statistically compared among the three groups. Results: Mean SCT times in the control, pre-dialysis, and dialysis groups were 11.7±5.7, 30.16±11.66, and 27.33±9.4 min, respectively. The results for both the predialysis and dialysis groups were significantly higher when compared with the control group (both p<0.001). There was no significant difference between the pre-dialysis and dialysis groups (p=0.22). Conclusion: Both CRF and haemodialysis treatment cause severe prolongation of MCC time. Patients with CRF should be monitored closely for middle ear, sinonasal, and respiratory tract infections and informed about potential risks of infection.

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“…Sinusitis or smoking in adults significantly lengthens the MCT [5]. Adenoid hyperplasia in children also significantly affects mucociliary function, and its degree negatively correlates with mucociliary capacity; however, a significant improvement in MCT is usually observed following surgical correction [2, 6]. Improvements in mucociliary function have also been noted in adult patients after quitting smoking [7].…”

Section: Introductionmentioning

confidence: 99%

Impact of Allergic Rhinitis on Nasal Mucociliary Clearance Time in Children

Mikolajczyk

Janukowicz

Majewska

et al. 2019

Int Arch Allergy Immunol

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Background: Mucociliary clearance is one of the most important protective functions of the airway. Previous studies, checking the influence of allergic rhinitis (AR) on mucociliary clearance time (MCT), were made on small patient groups and brought contradictive results. Objectives: The aim of the study is to confirm whether AR in children influences MCT. Methods: The examined group consisted of 842 AR children. A total of 96 children with no history of allergy rhinitis served as a comparative group. All patients underwent saccharin and skin prick tests and tests for blood eosinophilia, nasal eosinophilia, vitamin D3 serum concentration, total and specific IgE serum concentration. Results: Nasal MCT was significantly longer in AR patients (mean ± SD: 10.5 ± 5.65 min) compared to controls (mean ± SD: 7.25 ± 4.3 min). Percentage of eosinophils in nasal smears in patients was significantly higher compared to controls and a weak, but significant positive correlation was observed between the percentage and MCT (r > 0.10, p < 0.008). Patients with intermittent and persistent moderate/ severe AR had significantly longer MCT and higher eosinophilia in nasal smears compared both to patients with intermittent and persistent mild RA and controls. No correlation was observed between MCT and: participant’s age, total serum IgE, vitamin D3 serum concentration, absolute number or percentage of eosinophils in blood, prick test results or duration of illness. Conclusions: AR affects the mucociliary clearance in children, and its deterioration is related to more severe rhinitis with higher intensity of local nasal inflammation, reflected in nasal smear eosinophilia.

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Comparison of nasal mucociliary clearance in adenoid hypertrophy with or without otitis media with effusion

Cited by 21 publications

References 15 publications

Ciliary beat frequency in children with adenoid hypertrophy

Ciliary beat frequency in children with adenoid hypertrophy

Nasal mucociliary clearance in chronic renal failure: comparision of pre-dialysis and dialysis stages

Impact of Allergic Rhinitis on Nasal Mucociliary Clearance Time in Children

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