Comparison of narrow band and fluorescence molecular imaging to improve intraoperative tumour margin assessment in oral cancer surgery

Wit, Jaron G de; Schaik, Jeroen E. van; Voskuil, Floris; Vonk, Jasper; Visscher, Sebastiaan A. H. J. de; Schepman, Kees-Pieter; Laan, Bernard F.A.M. van der; Doff, Jan J.; Vegt, Bert van der; Plaat, Boudewijn E. C.; Witjes, Max

doi:10.1016/j.oraloncology.2022.106099

Cited by 14 publications

(18 citation statements)

References 31 publications

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“…This innovative technique, in conjunction with fluorescence-based imaging utilizing indocyanine green, facilitates precise delineation of tumors, potentially minimizing the requirement for extensive resections and thereby improving patient outcomes. In line with this, De Wit et al 22 recently published the results of a Phase II trial focusing on EGFR-targeted fluorescence molecular imaging for intraoperative margin assessment in oral cancer patients. Their findings revealed 100% sensitivity in detecting tumor-positive margins along with a specificity of 85.9%, potentially paving the way for more precise tumor resection with reduced incidence of positive margins.…”

Section: Technological and Scientific Advances In The Surgical Arenamentioning

confidence: 83%

“…Their findings revealed 100% sensitivity in detecting tumor-positive margins along with a specificity of 85.9%, potentially paving the way for more precise tumor resection with reduced incidence of positive margins. 22 Last, is the integration of robotics in head and neck surgery. Over the past decade, the field of head and neck surgery has seen significant advancements in robotic technology.…”

Section: Technological and Scientific Advances In The Surgical Arenamentioning

confidence: 99%

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Recent advances in head and neck surgical oncology

Ritter,

Levyn,

Shah

2023

Journal of Surgical Oncology

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In recent years, the field of head and neck oncology has witnessed a remarkable transformation with unprecedented advances that have revolutionized the management of complex tumors in this region. As an intricate subspecialty within oncology, head and neck surgical procedures demand detailed knowledge of the complex anatomy meticulous precision in surgical technique, and expertise to preserve vital functions while ensuring optimal oncological outcomes. With the relentless pursuit of improved patient outcomes, the integration of innovative technologies has significantly enhanced the surgical armamentarium. Robotics, endoscopic platforms, and image‐guided navigation have revolutionized the surgical approach, enabling precise tumor resection and sparing healthy tissues. Furthermore, the application of advanced imaging modalities and molecular biomarker profiling has opened new avenues for personalized treatment strategies. From targeted therapies and immunotherapies to adaptive radiation techniques, clinicians are now equipped with an array of tailored options, ushering in a new era of personalized care for patients with head and neck malignancies. This article delves into the unfolding narratives of clinical triumphs, exploring the transformative potential of emerging therapies and the collaborative efforts propelling head and neck surgical oncology toward a future of hope and healing.

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Section: Technological and Scientific Advances In The Surgical Arenamentioning

confidence: 83%

Section: Technological and Scientific Advances In The Surgical Arenamentioning

confidence: 99%

Recent advances in head and neck surgical oncology

Ritter,

Levyn,

Shah

2023

Journal of Surgical Oncology

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“…Although multi-disciplinary therapy, conservation of function surgery and reconstruction of function surgery treatments are available, patients are often at risk of disfigurement and disease recurrence (21,22). Therefore, finding new tumor markers and novel treatment methods for OSCC is very important (23,24).…”

Section: Discussionmentioning

confidence: 99%

BST2 regulated by the transcription factor STAT1 can promote metastasis, invasion and proliferation of oral squamous cell carcinoma via the AKT/ERK1/2 signaling pathway

Shan

Shen

Wang³

et al. 2023

Int J Oncol

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Oral squamous cell carcinoma (OSCC) is one of the main types of head and neck squamous cell carcinoma. Although progress has been made in treating OSCC, it remains a threat to human health, and novel therapeutic strategies are needed to extend the lifespan of patients with OSCC. The present study, evaluated whether bone marrow stromal antigen 2 (BST2) and STAT1 were potential therapeutic targets in OSCC. Small interfering RNA (siRNA) or overexpression plasmids were used to regulate BST2 or STAT1 expression. Western blotting and reverse transcription-quantitative PCR were performed to assess changes in the protein and mRNA expression levels of signaling pathway components. The effects of BST2 and STAT1 expression changes on the migration, invasion and proliferation of OSCC cells were assessed using the scratch test assay, Transwell assay and colony formation assay in vitro, respectively. Cell-derived xenograft models were used to evaluate the impact of BST2 and STAT1 on the occurrence and development of OSCC in vivo. Finally, it was demonstrated that BST2 expression was significantly upregulated in OSCC. Furthermore, it was demonstrated that high expression of BST2 in OSCC contributed to the metastasis, invasion and proliferation of OSCC cells. Moreover, it was demonstrated that the promoter region of BST2 was regulated by the transcription factor STAT1, and that the STAT1/BST2 axis could affect the behavior of OSCC via the AKT/ERK1/2 signaling pathway. In vivo studies also demonstrated that STAT1 downregulation inhibited OSCC growth by down-regulating BST2 expression via the AKT/ERK1/2 signaling pathway.

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“…Due to their serious metastasis and secondary infection, cancers have been the leading cause of human death. The general treatments of cancer include surgery [1,2], chemotherapy [3,4], radiotherapy [5,6], and so on. With the rapid development of nanotechnology and materials science [7][8][9][10], nano-drug delivery systems [11][12][13][14] have been widely concerned in the cancers' diagnosis [15] and treatment [16].…”

Section: Introductionmentioning

confidence: 99%

Novel rod‐like carbon nanomaterials as near infrared‐responsive drug delivery system for potential anticancer applications

Liu,

Du,

Liu

et al. 2024

Micro & Nano Letters

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The combination of chemotherapy and photothermal therapy shows great potential in cancer treatment, and the carbon nanomaterials have been attracted great attention in biomedical technology. However, it is still a great challenge to design stimuli‐responsive nano‐carbon‐based drug release systems with integrated functions. In this paper, rod‐like carbon nanomaterials (RCNs) were prepared by the soft template hydrothermal method with glucose as raw materials, which were proved to have high photothermal efficiency (∼23.7%), as well as good biocompatibility and excellent drug‐loading capacity. After that, RCNs were used to load doxorubicin (DOX) as DOX@RCNs for integrated photothermal/chemotherapy towards cancer, which demonstrated 52.2% higher cancer cell killing efficiency than that of RCNs under near infrared (NIR) irradiation in vitro. The authors’ approach provided a novel NIR‐responsive nano platform for combined photothermal/chemotherapy towards cancer, which was considered to be of great potential in anticancer applications.

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Comparison of narrow band and fluorescence molecular imaging to improve intraoperative tumour margin assessment in oral cancer surgery

Cited by 14 publications

References 31 publications

Recent advances in head and neck surgical oncology

Recent advances in head and neck surgical oncology

BST2 regulated by the transcription factor STAT1 can promote metastasis, invasion and proliferation of oral squamous cell carcinoma via the AKT/ERK1/2 signaling pathway

Novel rod‐like carbon nanomaterials as near infrared‐responsive drug delivery system for potential anticancer applications

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