Comparison of nanoparticle-selenium, selenium-enriched yeast and sodium selenite on the alleviation of cadmium-induced inflammation via NF-kB/IκB pathway in heart

Ge, Jing; Guo, Kai; Zhang, Cong; Talukder, Milton; Lv, Mei-Wei; Li, Jinyang; Li, Jinlong

doi:10.1016/j.scitotenv.2021.145442

Cited by 87 publications

(44 citation statements)

References 96 publications

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“…Selenium-containing supplements proved to be effective in blocking cytokine-induced upregulation of NF-κB and iNOS, thus reducing stress-related NO inflammatory levels in the hypothalamus and hippocampus of an animal model [ 125 ]. Selenium feed supplements in chickens alleviated cardiac injury, splenic lymphocytes, and splenic tissue damage associated with Cd-derived or Hg-derived inflammation, via the production of NO through the NF-κB/iNOS pathway [ 126 , 127 ].…”

Section: Cardiovascular Diseasementioning

confidence: 99%

The Role of Selenium in Pathologies: An Updated Review

2022

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Selenium is an essential microelement required for a number of biological functions. Selenium—and more specifically the amino acid selenocysteine—is present in at least 25 human selenoproteins involved in a wide variety of essential biological functions, ranging from the regulation of reactive oxygen species (ROS) concentration to the biosynthesis of hormones. These processes also play a central role in preventing and modulating the clinical outcome of several diseases, including cancer, diabetes, Alzheimer’s disease, mental disorders, cardiovascular disorders, fertility impairments, inflammation, and infections (including SARS-CoV-2). Over the past years, a number of studies focusing on the relationship between selenium and such pathologies have been reported. Generally, an adequate selenium nutritional state—and in some cases selenium supplementation—have been related to improved prognostic outcome and reduced risk of developing several diseases. On the other hand, supra-nutritional levels might have adverse effects. The results of recent studies focusing on these topics are summarized and discussed in this review, with particular emphasis on advances achieved in the last decade.

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Section: Cardiovascular Diseasementioning

confidence: 99%

The Role of Selenium in Pathologies: An Updated Review

2022

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“…For example, Na 2 SeO 3 , the most widely used Se form, exhibits excellent chemo-preventive and anticancer features [ 19 ], but SeNPs has been shown to be comparatively better as anticancer agent than Na 2 SeO 3 [ 20 ]. Besides, many studies have demonstrated that SeNPs had stronger biological activities like antioxidant activity, antidiabetic activity, improving reproduction and antagonizing cadmium-induced cardiotoxicity than Na 2 SeO 3 [ 21 , 22 , 23 , 24 ]. Therefore, SeNPs has been considered as a good candidate for replacement of other Se forms in clinical practice [ 17 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Selenium Nanoparticles and Sodium Selenite on the Alleviation of Early Atherosclerosis by Inhibiting Endothelial Dysfunction and Inflammation in Apolipoprotein E-Deficient Mice

Xiao

et al. 2021

IJMS

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Atherosclerosis and related cardiovascular diseases represent the greatest threats to human health, worldwide. Previous animal studies showed that selenium nanoparticles (SeNPs) and Na2SeO3 might have anti-atherosclerotic activity, but the underlying mechanisms are poorly elucidated. This study compared the anti-atherosclerotic activity of SeNPs stabilized with chitosan (CS-SeNPs) and Na2SeO3 and the related mechanism in a high-fat-diet-fed apolipoprotein E-deficient mouse model of atherosclerosis. The results showed that oral administration of both CS-SeNPs and Na2SeO3 (40 μg Se/kg/day) for 10 weeks significantly reduced atherosclerotic lesions in mouse aortae. Mechanistically, CS-SeNPs and Na2SeO3 not only alleviated vascular endothelial dysfunction, as evidenced by the increase of serum nitric oxide level and the decrease of aortic adhesion molecule expression, but also vascular inflammation, as evidenced by the decrease of macrophage recruitment as well as the expression of proinflammatory molecules. Importantly, these results were replicated within in-vivo experiments on the cultured human endothelial cell line EA.hy926. Overall, CS-SeNPs had a comparable effect with Na2SeO3 but might have more potential in atherosclerosis prevention due to its lower toxicity. Together, these results provide more insights into the mechanisms of selenium against atherosclerosis and further highlight the potential of selenium supplementation as a therapeutic strategy for atherosclerosis.

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“…These results were consistent with the experiments as follows. Zhang et al found that SeY antagonizes the inflammatory damage caused by Cd to chicken cardiomyocytes through the NF-κB signaling pathway [ 52 ], and Wang et al showed that the addition of Se could effectively downregulated the high-expression of NF-κB gene in chicken kidney tissue caused by Cd exposure [ 34 ]. These results demonstrated that the addition of SeY could effectively inhibit the phosphorylation of IκBα to prevent NF-κB from entering the nucleus and mitigate the inflammatory response.…”

Section: Discussionmentioning

confidence: 99%

Selenium-Enriched Yeast Relieves Hexavalent Chromium Toxicity by Inhibiting NF-κB Signaling Pathway in Broiler Spleens

Zhao

Hao

Zhang

et al. 2022

Animals

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This study was conducted to investigate the molecular mechanisms of selenium (Se) antagonism of hexavalent chromium (Cr6+)-induced toxicity. Potassium dichromate (K2Cr2O7) and selenium-enriched yeast (SeY) were used to construct the single Cr6+ and combined Se/Cr6+ exposure broiler models, and then the broilers were randomly divided into four groups (C group, Se group, Se/Cr6+ group, and Cr6+ group). After a 42-day experiment, the spleen tissues of broilers were excised and weighted. The antagonistic mechanisms of Se and Cr6+ were evaluated using histopathological assessment, serum biochemical tests, oxidative stress kits, ELISA, qPCR, and Western blotting. On the whole, there were no significant changes between the C and Se groups. The spleen organ index in the Cr6+ group was significantly decreased, but SeY increased spleen organ index to a certain extent. The levels of SOD and GSH were reduced, and the MDA content was elevated by Cr6+; however, these changes were mitigated by Se/Cr6+ exposure. Importantly, Cr6+ exposure induced a series of histopathological injuries in broiler spleen tissues, while these symptoms were significantly relieved in the Se/Cr6+group. Furthermore, Cr6+ significantly decreased the levels of T-globulin, IgA, IgM, and IgG in serum. Contrarily, dramatically more T-globulin IgA, IgM, and IgG were found in the Se/Cr6+group than in the Cr6+ group. Revealed by the results of qPCR and WB, the expressions of NF-κB, IκBα, and p-IκBα were upregulated in Cr6+ groups, while they were downregulated in Se/Cr6+ group compared to that in Cr6+ group. Besides IFN-γ and IL-2, the expressions of pro-inflammatory cytokines were significantly increased by Cr6+ exposure, but the SeY supplement relived the expression levels mediated by Cr6+ exposure. In conclusion, our findings suggest SeY has biological activity that can protect broiler spleens from immunosuppression and inflammation induced by Cr6+, and we speculate that the NF-κB signaling pathway is one of its mechanisms.

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Comparison of nanoparticle-selenium, selenium-enriched yeast and sodium selenite on the alleviation of cadmium-induced inflammation via NF-kB/IκB pathway in heart

Cited by 87 publications

References 96 publications

The Role of Selenium in Pathologies: An Updated Review

The Role of Selenium in Pathologies: An Updated Review

Comparison of Selenium Nanoparticles and Sodium Selenite on the Alleviation of Early Atherosclerosis by Inhibiting Endothelial Dysfunction and Inflammation in Apolipoprotein E-Deficient Mice

Selenium-Enriched Yeast Relieves Hexavalent Chromium Toxicity by Inhibiting NF-κB Signaling Pathway in Broiler Spleens

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